研究领域
Molecular recognition is central to all biological processes and is the basis of supramolecular chemistry and other related fields, for example, catalysis. We believe molecular recognition may provide the final solutions to some of the problems in the fields of analytical sciences, biomedical sciences, environmental sciences and materials sciences. However, the recognition ability of known synthetic receptors are far from satisfactory, especially when compared with that of bioreceptors. The Jiang group aims at exploring novel molecular recognition with biomimetic mechanisms and at providing model systems for understanding the fundamental principles of biomolecular recognition. The tools we used are the home-made, macrocyclic receptors with a biomimetic cavity feature. The knowledge learned will be further applied to sensing, separation, catalysis, machinery, self-assembly, and tuning biological activity.
The research scientists involved are exposed to diverse discplines, including organic synthesis, catalysis, supramolecular chemistry, physical chemistry, analytical chemistry, medicinal chemistry, materials chemistry, and polymer chemistry, and a variety of technologies, including computer modelling, 2D NMR, mass spectrometry, isothermal titration calorimetry (ITC), stopped-flow spectroscopy, spectroscopy, recycling HPLC, DLS, TEM, SEM…
Research Interests:
1. Design and Synthesis of Macrocyclic Receptors with a Biomimetic Cavity Feature;
2. Molecular Recognition of Polar Molecules/Groups in Water and the Related Physical Organic Chemistry;
3. Applications of Molecular Recognition in Sensing, Machines, Materials, Self-Assembly, and Chemical Biology.
近期论文
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Mechanical Training Enabled Reinforcement of Polyrotaxane-Containing Hydrogel Jia-Ni Jin, Xi-RanYang, Yan-Fang Wang, Lei-Min Zhao, Liu-Pan Yang, Liping Huang*, and Wei Jiang* Angew. Chem. Int. Ed. 2022, e202218313. DOI: 10.1002/anie.202218313
Non-Equilibrium Kinetic States of a [2]Rotaxane-Based Molecular Shuttle Controlled by Acid Concentrations Lei-Min Zhao, Li-Shuo Zheng, Xiaoping Wang*, and Wei Jiang* Angew. Chem. Int. Ed. 2022, e20221496. DOI: 10.1002/anie.202214296
The Influence of Small Biomolecules, Salts and Buffers on the Molecular Recognition of Amide Naphthotube in Aqueous Solutions Ming-Shuang Li,‡ Yi-Wei Dong,‡ Xin-Yu Pang,‡ Hongxin Chai, Xiaoping Wang, and Wei Jiang* Chem. Eur. J. 2022, 28, accepted. (‡ co-first author). DOI: 10.1002/chem.202202972
Conformational Effects on the Threading Kinetics of Dumbbell-Shaped Guests into the Cavity of Oxatub[4]arene Fei Jia, Dong-Hao Li, Shan He, Liu-Pan Yang*, and Wei Jiang* Angew. Chem. Int. Ed. 2022, 61, e202212305. DOI: 10.1002/anie.202212305
Synthesis, Configurational Analysis, Molecular Recognition and Chirality Sensing of Methylene-Bridged Naphthotubes Yan-Fang Wang, Huan Yao, Liu-Pan Yang, Mao Quan*, and Wei Jiang* Angew. Chem. Int. Ed. 2022, 61, e202211853. DOI: 10.1002/anie.202211853
Molecular Recognition and Spectral Tuning of Organic Dyes in Water by Amide Naphthotubes Zhao Chen, Mao Quan, Yi-Wei Dong, Ming-Shuang Li, Song-Meng Wang, Lei-Min Zhao, Liu-Pan Yang*, Jishan Wu* and Wei Jiang* Chem. Commun. 2022, 58, 9413-9416. DOI: 10.1039/D2CC03270H
Stabilization of Imines and Hemiaminals in Water by an Endo-Functionalized Container Molecule Ming-Shuang Li, Yi-Wei Dong, Mao Quan, and Wei Jiang* Angew. Chem. Int. Ed. 2022, 61, e202208508. DOI: 10.1002/anie.202208508
Cucurbit[n]urils (n = 7, 8) can strongly bind neutral hydrophilic molecules in water Ming-Shuang Li, Mao Quan, Xi-Ran Yang and Wei Jiang* Sci. China Chem. 2022, 65, 1733-1740. DOI: 10.1007/s11426-022-1312-5
Switchable Bifunctional Molecular Recognition in Water Using a pH-Responsive Endo-Functionalized Cavity Xiaoping Wang, Mao Quan, Huan Yao, Xin-Yu Pang, Hua Ke and Wei Jiang* Nat. Commun. 2022, 13, 2291. DOI: 10.1038/s41467-022-30012-4
Circular Dichroism-Based Chirality Sensing with Supramolecular Host-Guest Chemistry Mao Quan,‡ Xin-Yu Pang‡ and Wei Jiang* Angew. Chem. Int. Ed. 2022, 61, e202201258. (‡ co-first author). DOI: 10.1002/anie.202201258
Selective Recognition of Methyl Viologen by an Endo-Functionalized Naphthobox Wei-Er Liu, Ling-Hui Kong, Mao Quan, Huan Yao, Liu-Pan Yang*, Ho Yu Au-Yeung* and Wei Jiang* Chin. Chem. Lett. 2022, 33, 4896–4899. DOI:10.1016/j.cclet.2022.02.076
Molecular Recognition and Photoprotection of Riboflavin in Water by a Biomimetic Host Hong Zhang, Li-Li Wang,* Xin-Yu Pang, Liu-Pan Yang* and Wei Jiang* Chem. Commun. 2021, 57, 13724–13727. DOI: 10.1039/d1cc05818e
Biomimetic Recognition of Quinones in Water by an Endo-Functionalized Cavity with Anthracene Sidewalls Hang Zhou,‡ Xin-Yu Pang,‡ Xiaoping Wang, Huan Yao, Liu-Pan Yang and Wei Jiang* Angew. Chem. Int. Ed. 2021, 60, 25981–25987. (‡ co-first author). DOI: 10.1002/anie.202112267
Naphthobox: A Selective Molecular Box for Planar Aromatic Cations Xin-Yu Pang, Hang Zhou, Huan Yao and Wei Jiang* Org. Chem. Front. 2021, 8, 5265–5270. DOI: 10.1039/d1qo00819f
Effective and Rapid Removal of Polar Organic Micropollutants from Water by Amide Naphthotube-Crosslinked Polymers Liu-Pan Yang, Hua Ke, Huan Yao and Wei Jiang* Angew. Chem. Int. Ed. 2021, 60, 21404–21411. DOI: 10.1002/anie.202106998
Fluorescence Detected Circular Dichroism (FDCD) for Supramolecular Host–Guest Complexes Amrutha Prabodh, Yichuan Wang, Stephan Sinn, Paolo Albertini, Christian Spies, Eduard Spuling, Liu-Pan Yang, Wei Jiang, Stefan Brase* and Frank Biedermann* Chem. Sci. 2021, 12, 9420-9431. DOI: 10.1039/d1sc01411k
Biomimetic Recognition-Based Bioorthogonal Host-Guest Pairs for Cell Targeting and Tissue Imaging in Living Animals Yan-Long Ma,‡ Chen Sun,‡ Zeshun Li, Ziyi Wang, Jianwen Wei, Qian Cheng, Li-Shuo Zheng, Xiao-Yong Chang, Kai Li, Ruibing Wang* and Wei Jiang* CCS Chem. 2021, 4, 1977–1989. (‡ co-first author). DOI: 10.31635/ccschem.021.202101178
Pagoda[5]arene: An Emerging Anthracene-Based Macrocyclic Arene with a Deep and Well-Defined Cavity Yan-Fang Wang and Wei Jiang* Chin. J. Org. Chem. 2021, 41, 2141-2142. DOI: 10.6023/cjoc202100035
Selective Recognition of Quaternary Ammonium Ions by Structurally Flexible Cages Qi-Cheng Huang, Mao Quan, Huan Yao, Liu-Pan Yang* and Wei Jiang* Chin. J. Chem. 2021, 39, 1593-1598. DOI: 10.1002/cjoc.202000738
Biomimetic Recognition and Optical Sensing of Carboxylic Acids in Water by Using a Buried Salt Bridge and the Hydrophobic Effect Xuan Huang, Xiaoping Wang, Mao Quan, Huan Yao, Hua Ke, and Wei Jiang* Angew. Chem. Int. Ed. 2021, in press. DOI: 10.1002/anie.202012467
Potentiometric Determination of The Neurotransmitter Acetylcholine with Ion-Selective Electrodes Containing Oxatub[4]arenes as The Ionophore Qinghan Chen, Liu-Pan Yang, Dong-Hao Li, Jingying Zhai*, Wei Jiang* and Xiaojiang Xie* Sens. Actuators, B: Chem. 2021, 326, 128836. DOI: 10.1016/j.snb.2020.128836
Volumetric Properties for the Binding of 1,4-Dioxane to Amide Naphthotubes in Water Shujie Li, Huan Yao, Tomoshi Kamenda, Wei Jiang* and Ryo Kitahara* J. Phys. Chem. B. 2020, 124, 9175-9181. DOI: 10.1021/acs.jpcb.0c07690
A Green and Wide-Scope Approach for Chiroptical Sensing of Organic Molecules through Biomimetic Recognition in Water Li-Li Wang, Mao Quan, Ti-Long Yang, Zhao Chen, and Wei Jiang*Angew. Chem. Int. Ed. 2020, in press. DOI: 10.1002/anie.202011566
Stabilization of the Closed-Ring Isomer of Spiropyran by Amide Naphthotube in Water and Its Application in Naked-Eye Detection of Toxic Paraoxon Wei-Er Liu, Mao Quan, Hang Zhou, Liu-Pan Yang, Ho Yu Au-Yeung* and Wei Jiang* ChemPhysChem 2020, 21, 2249-2253. DOI: 10.1002/cphc.202000703
Adsorptive Separation of Benzene, Cyclohexene, and Cyclohexane by Amorphous Nonporous Amide Naphthotube Solids Huan Yao,‡ Yu-Mei Wang,‡ Mao Quan, M. Umar Farooq, Liu-Pan Yang* and Wei Jiang* Angew. Chem. Int. Ed. 2020, 59, 19945-19950. (‡ co-first author). DOI: 10.1002/anie.202009436
Biomimetic Recognition of Organic Drug Molecules in Water by Amide Naphthotubes Yan-Long Ma, Mao Quan, Xiu-Lian Lin, Qian Cheng, Huan Yao, Xi-Ran Yang, Ming-Shuang Li, Wei-Er Liu, Lin-Ming Bai, Ruibing Wang* and Wei Jiang* CCS Chem. 2020, 2, 1078-1092. DOI: 10.31635/ccschem.020.202000288
A Supramolecular System that Strictly Follows the Binding Mechanism of Conformational Selection Liu-Pan Yang, Li Zhang, Mao Quan, Jas S. Ward, Yan-Long Ma, Hang Zhou, Kari Rissanen and Wei Jiang* Nat. Commun. 2020, 11, 2740. DOI: 10.1038/s41467-020-16534-9
Conformationally Adaptive Macrocycles with Flipping Aromatic Sidewalls Xiaoping Wang,‡ Fei Jia,‡ Liu-Pan Yang, Hang Zhou and Wei Jiang* Chem. Soc. Rev. 2020, 49, 4176-4188. (‡ co-first author). DOI: 10.1039/D0CS00341G Highlighted as Inside Front Cover
Highlight: Prismarene: An Emerging Naphthol‐Based Macrocyclic Arene Liu-Pan Yang and Wei Jiang* Angew. Chem. Int. Ed. 2020, 59, 15794-15796. DOI: 10.1002/anie.202003423
Enantioselective Recognition of Neutral Molecules in Water by a Pair of Chiral Biomimetic Macrocyclic Receptors Hongxin Chai,‡ Zhao Chen,‡ Sheng-Hua Wang, Mao Quan, Liu-Pan Yang, Hua Ke and Wei Jiang* CCS Chem. 2020, 2, 440-452. (‡ co-first author). DOI: 10.31635/ccschem.020.202000160
Mono-Functionalized Derivatives and Revised Configurational Assignment of Amide Naphthotubes Huan Yao,‡ Xiaoping Wang,‡ Mo Xie, Yu-Mei Wang, Mao Quan, Liu-Pan Yang and Wei Jiang* Org. Biomol. Chem. 2020, 18, 1900-1909. (‡ co-first author). DOI: 10.1039/D0OB00290A
Redox-Responsive Host–Guest Chemistry of a Flexible Cage with Naphthalene Walls Fei Jia, Hendrik V. Schröder, Liu-Pan Yang, Carolina von Essen, Sebastian Sobottka, Biprajit Sarkar, Kari Rissanen, Wei Jiang* and Christoph A. Schalley* J. Am. Chem. Soc. 2020, 142, 3306-3310. DOI: 10.1021/jacs.9b11685
Naphthotubes: Macrocyclic Hosts with a Biomimetic Cavity Feature Liu-Pan Yang, Xiaoping Wang, Huan Yao and Wei Jiang* Acc. Chem. Res. 2020, 53, 198-208. DOI: 10.1021/acs.accounts.9b00415
A 2,3-Dialkoxynaphthalene-Based Naphthocage Song-Bo Lu,‡ Hongxin Chai,‡ Jas S. Ward, Mao Quan, Jin Zhang, Kari Rissanen, Ray Luo, Liu-Pan Yang* and Wei Jiang* Chem. Commun. 2020, 56, 888-891. (‡ co-first author). DOI: 10.1039/C9CC09585C
Biomimetic Synchronized Motion of Two Interacting Macrocycles in [3]Rotaxane‐Based Molecular Shuttles Li-Shuo Zheng,‡ Jie-Shun Cui‡ and Wei Jiang* Angew. Chem. Int. Ed. 2019, 58, 15136-15141. (‡ co-first author). DOI: 10.1002/anie.201910318
Unexpected Solvent Effect on the Binding of Positively-Charged Macrocycles to Neutral Aromatic Hydrocarbons Yu-Mei Wang, Huan Yao, Mao Quan, Hongxin Chai, Liu-Pan Yang, Ying-Ming Pan* and Wei Jiang* Chem. Commun. 2019, 55, 10924-10927. DOI: 10.1039/C9CC06154A
Molecular Recognition of Organophosphorus Compounds in Water and Inhibition of Their Toxicity to Acetylcholinesterase Wei-Er Liu, Zhao Chen, Liu-Pan Yang, Ho-Yu Au-Yeung* and Wei Jiang* Chem. Commun. 2019, 55, 9797-9800. DOI: 10.1039/C9CC04603H
Selective Recognition of Phenazine by 2,6‐Dibutoxylnaphthalene‐Based Tetralactam Macrocycle Li-Li Wang, Yi-Kuan Tu, Arto Valkonen, Kari Rissanen and Wei Jiang* Chin. J. Chem. 2019, 37, 892-896. DOI: 10.1002/cjoc.201900233
2,3-Dibutoxynaphthalene-Based Tetralactam Macrocycles for Recognizing Precious Metal Chloride Complexes Li-Li Wang, Yi-Kuan Tu, Huan Yao and Wei Jiang* Beilstein J. Org. Chem. 2019, 15, 1460-1467. DOI: 10.3762/bjoc.15.146
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