个人简介
Dr. Zhen Gu is a Full Professor in the Department of Bioengineering and Director of the NIH Biotechnology Training in Biomedical Sciences and Engineering Program at the University of California, Los Angeles (UCLA). Dr. Gu received his B.S. degree in Chemistry and M.S. degree in Polymer Chemistry and Physics from Nanjing University. In 2010, he obtained Ph.D. at UCLA, under the guidance of Dr. Yi Tang in the Department of Chemical and Biomolecular Engineering. He was a Postdoctoral Associate working with Dr. Robert Langer at MIT and Harvard Medical School during 2010 to 2012. Before he moved to UCLA in 2018, he had been appointed as a Jackson Family Distinguished Professor in the Joint Department of Biomedical Engineering at the University of North Carolina at Chapel Hill and North Carolina State University.Dr. Gu’s group studies controlled drug delivery, bio-inspired materials and nanobiotechnology, especially for cancer and diabetes treatment. He has published over 160 research papers and applied over 50 patents. He is a co-founder of five start-up companies. He serves as an Associate Editor for Nano Research and Focus Group Chair of Bioinspired and Biomimetic Drug Delivery (BBDD) in the Controlled Release Society (CRS). Dr. Gu is the recipient of the Sloan Research Fellowship (2016), Biomaterials Science Lectureship Award (2018), Young Investigator Award of CRS (2017), Alcoa Foundation Research Achievement Award (2017), Pathway Award of the American Diabetes Association (ADA, 2015) and Young Innovator Award in Cellular and Molecular Engineering of the Biomedical Engineering Society (BMES, 2015). MIT Technology Review listed him in 2015 as one of the global top innovators under the age of 35 (TR35). He was elected to the College of Fellows of the American Institute for Medical and Biological Engineering (AIMBE) in 2019.
Education
2010 PHD University of California, Los Angeles (UCLA), USA
2006 MSN anjing University, China
2003 BS Nanjing University, China
Professional Appointments
2018-present Professor University of California, Los Angeles, USA
2016-2018 Associate Professor University of North Carolina at Chapel Hill | North Carolina State University, USA
2012-2016 Assistant Professor University of North Carolina at Chapel Hill | North Carolina State University, USA
2010-2012 Postdoctoral Fellow MIT | Harvard Medical School, USA
近期论文
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Jicheng Yu, Jinqiang Wang, Yuqi Zhang, Guojun Chen, Weiwei Mao, Yanqi Ye, Anna R. Kahkoska, John B. Buse, Robert Langer, and Zhen Gu*, “Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs", Nature Biomedical Engineering, 4(499), 2020 Link. Watch Video Introduction: Youtube or Youku
Guojun Chen+, Zhitong Chen+, Di Wen, Zejun Wang, Hongjun Li, Yi Zeng, Gianpietro Dotti, Richard Wirz*, and Zhen Gu*, “Transdermal cold atmospheric plasma-mediated immune checkpoint blockade therapy”, Proceedings of the National Academy of Sciences U.S.A. (PNAS), 7(3687), 2020. Link
Quan Zhou+, Shiqun Shao+, Jinqiang Wang, Changhuo Xu, Jiajia Xiang, Ying Piao, Zhuxian Zhou, Qingsong Yu, Jianbin Tang, Xiangrui Liu, Zhihua Gan, Ran Mo, Zhen Gu*, and Youqing Shen*, “Enzyme-Activatable Polymer-Drug Conjugate Augments Tumour Penetration and Treatment Efficacy”, Nature Nanotechnology, 14(799), 2019. Link
Di Wen, Jinqiang Wang, George Van Den Driessche, Qian Chen, Yuqi Zhang, Guojun Chen, Hongjun Li, Jennifer Soto, Ming Liu, Masao Ohashi, Zejun Wang, Peter Abdou, Quanyin Hu, Gianpietro Dotti, Song Li, Denis Fourches, and Zhen Gu*, “Adipocytes as Anticancer Drug Delivery Depot”, Matter, 5(1203), 2019. (Cover) Link
Jinqiang Wang, Jicheng Yu, Yuqi Zhang, Anna R.Kahkoska, Zejun Wang, Jun Fang, Julian P. Whitelegge, Song Li, John B. Buse, and Zhen Gu*, “Glucose Transporter Inhibitor-Conjugated Insulin Mitigates Hypoglycemia”, Proceedings of the National Academy of Sciences U.S.A. (PNAS), 22(10744), 2019. Link
Zhaowei Chen, Zejun Wang, and Zhen Gu*, “Bioinspired and Biomimetic Nanomedicines”, Accounts of Chemical Research, 5(1255), 2019. Link
Qian Chen, Chao Wang, Xudong Zhang, Guojun Chen, Quanyin Hu, Hongjun Li, Jinqiang Wang, Di Wen, Yuqi Zhang, Yifei Lu, Guang Yang, Chen Jiang, Jun Wang, Gianpietro Dotti and Zhen Gu*, “In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment”, Nature Nanotechnology, 14(89), 2019. Link (View PDF) Also see: Nat. Nano’s highlights
Quanyin Hu, Wujin Sun, Jinqiang Wang, Huitong Ruan, Xudong Zhang, Yanqi Ye, Song Shen, Chao Wang, Weiyue Lu, Ke Cheng, Gianpietro Dotti, Joshua F. Zeidner, Jun Wang, and Zhen Gu*, “Conjugation of Haematopoietic Stem Cells and Platelets Decorated with Anti-PD-1 Antibodies Augments Anti-leukaemia Efficacy”, Nature Biomedical Engineering, 2(831), 2018. Link (View PDF) also see: Nat. Biomed. Eng’s highlight (View PDF)
Zhaowei Chen, Jinqiang Wang, Wujin Sun, Edikan Archibong, Anna R. Kahkoska, Xudong Zhang, Yue Lu, Frances S. Ligler, John B. Buse, Zhen Gu*, “Synthetic β-cells for Fusion-Mediated Dynamic Insulin Secretion”, Nature Chemical Biology, 14(86), 2018. Link also see: JAMA‘s highlight
Chao Wang+, Jinqiang Wang+, Xudong Zhang, Shuangjiang Yu, Di Wen, Quanyin Hu, Yanqi Ye, Hunter Bomba, Xiuli Hu, Zhuang Liu, Gianpietro Dotti, Zhen Gu*, “In Situ Formed Reactive Oxygen Species-Responsive Scaffold with Gemcitabine and Checkpoint Inhibitor for Combination Therapy”, Science Translational Medicine, 10(eaan3682), 2018. Link also see: Nat. Rev. Cancer‘s highlight
Jicheng Yu, Yuqi Zhang, Yanqi Ye, Rocco DiSanto, Wujin Sun, Davis Ranson, Frances Ligler, John Buse, Zhen Gu*, “Microneedle-Array Patches Loaded with Hypoxia-Sensitive Vesicles Provide Fast Glucose-Responsive Insulin Delivery”, Proceedings of the National Academy of Sciences U.S.A. (PNAS), 112(8260), 2015. Link also see: Nature‘s highlight
Chao Wang, Wujin Sun, Yanqi Ye, Quanyin Hu, Hunter Bomba, Zhen Gu*, " In situ Activation of Platelets with Checkpoint Inhibitors for Post-Surgical Cancer Immunotherapy", Nature Biomedical Engineering, 0011, 2017. Link (View PDF) also see: Nat. Rev. Clin. Oncol‘s highlight (View PDF)
Yue Lu, Alex Aimetti, Robert Langer*, Zhen Gu*, “Bioresponsive Materials”, Nature Reviews Materials, 2(16075), 2016 Link (View PDF)
Naveed Bakh, Mabel Cortinas, Michael Weiss, Robert Langer, Daniel Anderson, Zhen Gu, Sanjoy Dutta, Michael Strano*, “Glucose-Responsive Insulin by Molecular and physical Design”, Nature Chemistry, 9(937), 2017. Link
Jicheng Yu, Yuqi Zhang, Zhen Gu*, “Advances in Bioresponsive Closed-loop Drug Delivery Systems", International Journal of Pharmaceutics, 544(350), 2018. Link
Wujin Sun, Wenyan Ji, Quanyin Hu, Zhen Gu*, “Leveraging Physiology for Precision Drug Delivery”, Physiological Reviews, 97(189), 2017. Link
Yuqi Zhang, Jicheng Yu, Hunter Bomba, Yong Zhu, Zhen Gu*, “Mechanical Force-Triggered Drug Delivery”, Chemical Reviews, 116(19), 2016. Link
Jicheng Yu, Yuqi Zhang, Anna R. Kahkoska, Zhen Gu*, “Bioresponsive Transcutaneous Patches", Current Opinion in Biotechnology, 48(28), 2017. Link
Yue Lu, Quanyin Hu, Yiliang Lin, Dennis B. Pacardo, Chao Wang, Wujin Sun, Frances S. Ligler, Michael D. Dickey, Zhen Gu*, “Transformable Liquid-Metal Nanomedicine”, Nature Communications, 6(10066), 2015. Link
Wujin Sun, Wenyan Ji, Jordan M. Hall, Quanyin Hu, Chao Wang, Chase L. Beisel, Zhen Gu*, “Self‐Assembled DNA Nanoclews for the Efficient Delivery of CRISPR–Cas9 for Genome Editing”, Angewandte Chemie International Edition, 127(12197), 2015. Link