聂立铭 - 厦门大学 - 公共卫生学院

个人简介

聂立铭博士多年来围绕高分辨率、高灵敏度的光学成像技术研发、生物医学应用及临床转化等方面开展工作；开发了快速无损、方便简易的光声层析及显微成像系统；设计了靶向性、智能化与功能化诊疗纳米探针；实现了结构、功能、分子及基因层面的生物成像；拓展了电子工程、光学光声技术在血管生物学、肿瘤学、分子影像学和神经学等学科的应用；提供了早期疾病诊断和疗效监控的有效、低成本、多尺度的影像手段和医疗设备。作为项目负责人主持国家自然科学基金青年基金项目一项、主持科技部863子项目一项、参与科技部973项目一项。

研究领域

1. 新型光学、荧光、光声成像技术拓展开发、装置研制及产业转化； 2. 国际前沿的光学、光声成像手段在肿瘤、心脑血管病、神经学等重大疾病及医学领域的基础研究及临床诊断； 3. 高分辨率荧光显微镜、光声显微镜在结构、功能上多尺度的生物分子成像应用，实现单细胞甚至单分子水平的可视化观察； 4．智能化、功能化、靶向性诊疗纳米探针的设计合成及其在高灵敏度、高特异性检测成像中应用。

近期论文

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Tang Y., Hu H., Zhang M. G., Song J., Nie L., Wang S., ... & Chen X.. An aptamer-targetingphotoresponsive drug delivery system using “off–on” graphene oxide wrappedmesoporous silica nanoparticles. Nanoscale, 2015, 7(14): 6304-6310. (IF 6.7) Nie L.*, Huang P., Li W., Yan X., Jin A., Wang, Z. et al.Early-Stage Imaging of Nanocarrier-Enhanced Chemotherapy Response in LivingSubjects by Scalable Photoacoustic Microscopy. Acs Nano, 2014,8(12):12141-50. (IF 12.0) Hu H., Huang P., Weiss O., Yan X., Yue X., Zhang M., Tang Y., Nie L., Ma Y., Niu G., Wu K., Chen X., PET and NIR opticalimaging using self-illuminating 64Cu-doped chelator-free gold nanoclusters,Biomaterials, 35(37), 9868-9876. (2014). (IF 8.3) Li W., Sun X., Wang Y., Niu G., Chen X., Qian Z., & Nie L.* In vivo quantitative photoacoustic microscopy ofgold nanostar kinetics in mouse organs. Biomedical Optics Express, 5(8),2679-2685. (2014). (IF 3.5) Nie L. and Chen X., “Structural and functionalphotoacoustic molecular tomography aided by emerging contrast agents,” Chem.Soc. Rev. 43 (20), 7132-7170. (2014). (IF 30.4) Huang P., Rong P., Lin J., Li W., Yan X., Zhang M., Nie L., Niu G., Lu J., Wang W., Chen X., “TriphaseInterface Synthesis of Plasmonic Gold Bellflowers as Near-infrared LightMediated Acoustic/Thermal Theranostics,” J. Am. Chem. Soc., 136(23), 8307–8313.(2014). (IF 11.4) Nie L., Wang S., Wang X., Rong P., Ma Y., Liu G., HuangP., Lu G., Chen X., “In vivo Volumetric Photoacoustic Molecular Angiography andTherapeutic Monitoring with Targeted Plasmonic Nanostars,” Small 10 (8),1585-1593. (2014). (IF 7.8) Rong P., Yang K., Srivastan A., Kiesewetter D. O., Yue X., Wang F., Nie L., Bhirde A., Wang Z., Liu Z., Niu G., Wang W., ChenX., “Photosensitizer Loaded Nano-Graphene for Multimodality Imaging GuidedTumor Photodynamic Therapy,” Theranostics 4(3), 229-239. (2014). (IF 7.8) Yang K., Zhu L., Nie L., Sun X., Cheng L., Wu C., Niu G., Chen X., Liu Z., “Visualization ofprotease activity in vivo using an activatable photo-acoustic imaging probebased on CuS nanoparticles,” Theranostics 4 (2), 134-141. (2014). (IF 7.8) Nie L., Chen M., Sun X., Rong P., Zheng N., Chen X.,“Palladium nanosheets as highly stable and effective contrast agents for invivo photoacoustic molecular imaging,” Nanoscale 6 (3), 1271-1276. (2014). (IF 6.7) Lalwani G., Cai X., Nie L., Wang L. V., Sitharaman B., “Graphene-based contrast agents forphotoacoustic and thermoacoustic tomography,” Photoacoustics 1(3), 62-67.(2013). Huang C., Wang K., Nie L., Wang L. V., Anastasio M. A. “Full-Wave Iterative Image Reconstructionin Photoacoustic Tomography with Acoustically Inhomogeneous Media,” IEEE Trans.Med. Imaging. 32(6), 1097-1110. (2013). (IF3.8) Wang Z., Zhang X., Huang P., Zhao W., Liu D, Nie L., Yue X., Wang S., Ma Y., Kiesewetter D., Niu G.,Chen X. “Dual-factor triggered fluorogenic nanoprobe for ultrahigh contrast andsubdiffraction fluorescence imaging,” Biomaterials. 34(26), 6194-6201. (2013). (IF 8.3) Wang S., Huang P., Nie L., Xing R., Liu D., Wang Z., & Chen X et al. “Single Continuous WaveLaser Induced Photodynamic/Plasmonic Photothermal Therapy Using Photosensitizer‐Functionalized Gold Nanostars,” Adv. Mater. 25(22),3009-3009. (2013). (IF 15.4) Nie L.* “Biomedical Nanotechnology for Optical MolecularImaging, Diagnostics, and Therapeutics.” JSM. Nanotechnol. Nanomed. 1-2, (2013). Sun Z., Huang P., Tong G., Lin J., Jin A., Rong P., Zhu L., Nie L. et al, “VEGF-loaded Graphene Oxide as Theranosticsfor Multi-Modality Imaging-Monitored Targeting Therapeutic Angiogenesis ofIschemic Muscle,” Nanoscale. 5, 6857-6866. (2013). (IF 6.7) Nie L.†, Cai X.†, Maslov K., Garcia-Uribe A.,Anastasio M. A., and Wang L. V., “Photoacoustic tomography through a wholeadult human skull with a photon recycler,” J. Biomed. Opt. 17(11), 110506.(2012). (†Equal contribution) (IF 2.75) Huang C.†, Nie L.†, Schoonover R. W, Guo Z., Schirra C., Anastasio M.A., Wang L. V., “Aberration correction for transcranial photoacoustictomography of primates employing adjunct image data,” J. Biomed. Opt. 17(6)066016. (2012). (†Equal contribution) (IF2.75) Huang C.†, Nie L.†, Schoonover R. W, Wang L. V., Anastasio M. A., “Photoacoustic computedtomography correcting for heterogeneity and attenuation,” J. Biomed. Opt.17(6), 061211. (2012). (†Equal contribution) (IF 2.75) Nie L., Guo Z., Wang L. V., “Photoacoustic tomography ofmonkey brain using virtual point ultrasonic transducers,” J. Biomed. Opt.16(7), 076005. (2011). (IF 2.75)