个人简介

IU Dean's Fellow (2013 - present) Sloan Research Fellow (2013 - present) Cottrell Scholar Award (2012 - present) NSF CAREER Award (2012 - present) IU Outstanding Junior Faculty Award (2012) NIH Director's New Innovator Award (DP2, 2011 - present) Pew Biomedical Scholar (2010-present) NIH Pathway to Independence Award (K99/R00, 2007 - 2011) American Cancer Society Postdoctoral Fellow (2006 - 2007) Ralph F. Hirshmann - Daniel H. Rich Graduate Award in Bio-organic Chemistry (2005) NIH Predoctoral Fellow, Biotechnology Training Program (2001 - 2004) American Institute of Chemists Foundation: Outstanding Senior Student (2000) Phi Lambda Upsilon (Honorary Chemical Society, 2000) Phi Beta Kappa (Academic Honor Society, 2000)

研究领域

Chemical Biology/Organic Chemistry/Analytical & Bioanalytical Chemistry

Given the dearth of new antibacterial drugs and the facile evolution of microbial resistance, some fear that we have entered the “post-antibiotic era.” The Carlson Group unites tools from chemistry and biology to promote the development and application of technologies that will contribute to our understanding of new strategies for treatment of bacterial infections and the discovery of efficacious compounds. We are pursuing three complementary research directions: 1) Protein Function – design and application of chemical probes for characterization of the cellular targets of existing antibacterial agents, the penicillin-binding proteins, to advance our understanding of the biochemical pathways implicated in bacterial growth and pathogenicity; 2) Target Exploration – generation of methods for the investigation and inhibition of histidine kinases, proteins involved in bacterial development, virulence and antibiotic resistance, which remains difficult due to the lack of practical tools or a detailed understanding of protein-ligand interactions; 3) Molecule Discovery – development of strategies to dramatically expand our ability to explore natural product chemical space, with the goal of identifying privileged structures and novel antibacterial agents. We are constructing a toolkit of functional group-specific tags to facilitate compound isolation and a platform that combines mass spectrometry and informatics to assist in the detection of novel extract components and accelerate the structure elucidation process. Projects in Dr. Carlson's research group are highly multidisciplinary and members will gain expertise in many areas of chemistry such as organic synthesis, mass spectrometry, proteomics, metabolomics, microscopy and molecular modeling. In addition, members will utilize biological techniques from the fields of biochemistry, cell biology and genetics.

近期论文

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Kocaoglu, O.; Carlson, E. E. Profiling of β-Lactam Selectivity for Penicillin-Binding Proteins in Escherichia coli DC2. Antimicrob. Agents Chemother. 2015, Accepted. Wilke, K. E.; Francis, S.; Carlson, E. E. Inactivation of Multiple Bacterial Histidine Kinases by Targeting the ATP-Binding Domain. ACS Chem. Biol. 2015, 10, 328-335. Sidebottom, A. M. and Carlson, E. E. A Reinvigorated Era of Bacterial Secondary Metabolite Discovery. Curr. Opin. Chem. Biol. 2015, 24, 104-111. Tsui, H-C. T.;* Boesma, M.;* Vella, S.; Kocaoglu, O.; Kuru, E.; Perceny, J.; Carlson, E. E.; VanNieuwenhze, M. S.; Brun. Y. V.; Shaw, S.; Winkler, M. E. Separate Localization of Penicillin-Binding Protein Pbp2x from Pbp2b and Other Peptidoglycan Synthesis Proteins During Later Division Stages of Streptococcus pneumoniae D39. Mol. Microbiol. 2014, 94, 21-40. Johnson, A. R.; Dilger, J. M.; Glover, M. S.; Clemmer, D. E.; Carlson, E. E. Negatively-Charged Helices in the Gas Phase. ChemComm. 2014, 50, 8849-8851. Invited article in 2015 Emerging Investigators Issue. Trader, D. J.; Carlson, E. E. Towards the Development of Solid Supported Reagents for Separation of Alcohol-Containing Compounds by Steric Environment. Tetrahedron, 2014, 70, 4191-4196. Invited article in Special Issue to honor Sarah Reisman for receipt of the Tetrahedron Young Investigator Award. Tsui, H-C. T.;* Land, A. D.;* Kocaoglu, O.; Vella, S.; Shaw, S.; Keen, S.; Sham, L.-T.; Carlson, E. E.; Winkler, M. E. Requirement of Essential Pbp2x and GpsB for Septal Ring Closure in Streptococcus pneumoniae D39. Mol. Microbiol. 2013, 90, 939-955. Wilke, K. E.; Carlson, E. E. All Signals Lost. Sci. Transl. Med. 2013, 5, 203ps12. Invited Perspective. Kocaoglu, O.; Carlson, E. E. Penicillin-Binding Protein Imaging Probes. Curr. Prot. Chem. Bio. 2013, 5, 239-250. Trader, D. J.; Carlson, E. E. Taming of a Superbase for Selective Phenol Desilylation and Natural Product Isolation. J. Org. Chem. 2013, 78, 7349-7355. Sidebottom, A. M.; Johnson, A. R.; Karty, J. A.; Trader, D. J. and Carlson, E. E. Integrated Metabolomics Approach Facilitates Discovery of an Unpredicted Natural Product Suite from Streptomyces coelicolor M145. ACS Chem. Biol. 2013, 8, 2009-2016. Garber, K. C. A. and Carlson, E. E. Thiol-ene Enabled Detection of Thiophosphorylated Kinase Substrates. ACS Chem. Biol. 2013, 8, 1671-1676. Garber, K. C. A.*; Odendaal, A. Y*.; Carlson, E. E. Plant Pigment Identification: A Classroom and Outreach Activity. J. Chem. Ed. 2013, 90, 755-759. Francis, S.; Wilke, K. E.; Brown, D. E.; Carlson, E. E. Mechanistic Insight into Inhibition of Two-Component System Signaling. Med. Chem. Commun. 2013, 4, 269-277. Invited Article in the New Talent Themed Issue. Kocaoglu, O.; Calvo, R. A.; Sham, L. T.; Cozy, L. M.*; Lanning, B. R.*; Francis, S.; Winkler, M. E.; Kearns, D. B.; Carlson, E. E. Selective Penicillin-Binding Protein Imaging Probes Reveal Substructure in Bacterial Cell Division. ACS Chem. Biol. 2012, 7, 1746-1753. Wilke, K. E.; Francis, S.; Carlson, E. E. Activity-Based Probe for Histidine Kinase Signaling. J. Am. Chem. Soc. 2012, 134, 9150–9153. Trader, D. J. and Carlson, E. E. Chemoselective Hydroxyl Group Transformation: An Elusive Target. Mol. BioSyst. 2012, 8, 2484-2493. Invited Review in Emerging Investigators Themed Issue. Trader, D. J.; Carlson, E. E. Siloxyl Ether Functionalized Resins for Chemoselective Enrichment of Carboxylic Acids. Org. Lett. 2011, 13, 5652-5655. Odendaal, A. Y*.; Trader, D. J*.; Carlson, E. E. Chemoselective enrichment for natural products discovery. Chem. Sci. 2011, 2, 760-764. Carlson, E. E. Mass spectrometry for systems-level biological analysis. Nat. Chem. Bio. 2010, DOI: 10.1038/nchembio.490. Invited Primer.