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个人简介

学习经历 2004-2009年 Ph.D. 理学博士学位,专业: 有机化学; 研究方向: 不对称催化化;授予学校:四川大学; 导师:冯小明 院士 2000-2004 年 B.S. 理学学士学位,专业: 应用化学;授予学校:四川大学; 工作经历 2015-今 四川大学化学学院,特聘研究员,教授,博士生导师,研究方向:生物正交化学,光点击化学 2014-2015 年研究助理教授,专业,化学生物学,研究方向:生物正交化学,光点击化学;完成单位:美国纽约州立大学布法罗分校化学系 2009-2014 年博士后研究助理,专业,化学生物学,研究方向:生物正交化学,光点击化学;完成单位:美国纽约州立大学布法罗分校化学系;合作导师:Qing Lin 教授 主要奖励和荣誉 2021 第十三批 四川省学术和技术学术带头人后备人选 2019 Thieme Chemistry Journals Award (由Thieme数据库三大著名有机化学期刊Synthesis、Synlett和Synfact的学术编委会在全球范围遴选,授予在有机化学研究领域取得出色成果,并拥有巨大发展潜力的青年化学家) 2016 入选四川省高层次人才引进计划青年项目目 2015 入选国家级四青人才项目 2008 宝钢教育奖, 宝钢优秀学生特等奖

研究领域

有机化学

有机合成化学;“光点击”化学;活性分子的生物合成;生物正交化学;生物定向进化

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Fuqiang Hu, Cefei Zhang, Zhihao Liu, Xinyu Xie, Xiaohu Zhao, Yanju Luo, Jielin Fu, Baolin Li, Changwei Hu, Zhishan Su* and Zhipeng Yu,* titled "Photoswitchable and long-lived seven-membered cyclic singlet diradicals for the bioorthogonal photoclick reaction" Chem. Sci., 2023, 14, 13254–13264. Jielin Fu, Sitong Li, Lijun Deng, Xiaohu Zhao and Zhipeng Yu,* titled "A genetically encodable and fluorogenic photo-crosslinker via photo-induced defluorination acyl fluoride exchange" Chem. Commun., 2023, 59, 11073–11076. Lijun Deng, Cefei Zhang, Baolin Li, Jielin Fu, Zhong Zhang, Sitong Li, Xiaohu Zhao, Zhishan Su, Changwei Hu,* and Zhipeng Yu,* titled "Photo-induced defluorination acyl fluoride exchange as a fluorogenic photo-click reaction for photo-affinity labeling" Chem. Sci., 2023, 14, 3630–3641. Xinyu Xie, Fuqiang Hu, Yuqiao Zhou, Zhihao Liu, Xin Shen, Jielin Fu, Xiaohu Zhao, and Zhipeng Yu,* titled "Photoswitchable Oxidopyrylium Ylide for Photoclick Reaction with High Spatiotemporal Precision: A Dynamic Switching Strategy to Compensate for Molecular Diffusion" Angew. Chem. Int. Ed., 2023, 62, e202300034. Tingting Zheng, Jielin Fu, Qin Xiong, Xin Shen, Baolin Li, Xiaohu Zhao and Zhipeng Yu,* titled "Photo-regulated genetic encoding of dibenzo[c,g][1,2]diazocine on proteins via configuration switching" Chem. Commun., 2023, 59, 1201–1204. Xin Shen, Cefei Zhang, Fengying Lan, Zhishan Su, Yuanqin Zheng, Tingting Zheng, Qin Xiong, Xinyu Xie, Guangxi Du, Xiaohu Zhao, Changwei Hu,* Pengchi Deng,* and Zhipeng Yu,* titled "Dibenzo[b,f][1,4,5]chalcogenadiazepine Photoswitches: Conversion of Excitation Energy into Ring Strain" Angew. Chem. Int. Ed. 2022, e202209441. Qin Xiong, Tingting Zheng, Xin Shen, Baolin Li, Jielin Fu, Xiaohu Zhao, Chunxia Wang and Zhipeng Yu,* titled "Expanding the functionality of proteins with genetically encoded dibenzo[b,f][1,4,5] thiadiazepine: a photo-transducer for photo-click decoration" Chem. Sci., 2022, 13, 3571-3581. Hui Liu, Tingting Zheng, Yuanqin Zheng, Baolin Li, Xinyu Xie, Xin Shen, Xiaohu Zhao,* and Zhipeng Yu,* titled "Visible-light induced photo-click and release strategy between monoarylsydnone and phenoxylfumarate" Chem. Commun., 2021, 57, 8135-8138. Yuanqin Zheng, Yuqiao Zhou, Shichao Jiang, Xinyu Xie, Guangxi Du, Xin Shen, Xiaohu Zhao* and Zhipeng Yu,* titled "Rapid construction of bicyclic triazoline skeletons with dual-state emission via cycloaddition reaction of 4-phenyl-1,2,4-triazoline-3,5-dione with vinyl azides" Org. Chem. Front., 2023, 10, 1495-1504. Yuanqin Zheng, Yuqiao Zhou, Yan Zhang, Pengchi Deng, Xiaohu Zhao, Shichao Jiang, Guangxi Du, Xin Shen, Xinyu Xie, Zhishan Su,* and Zhipeng Yu,* titled "Water-Involved Ring-Opening of 4-Phenyl-1,2,4-triazoline-3,5-dione for “Photo-Clicked” Access to Carbamoyl Formazan Photoswitches In Situ" Chem Asian J., 2022, 17, e202101239. Jingshuo Gao, Qin Xiong, Xueting Wu, Jiajie Deng, Xiaocui Zhang, Xiaohu Zhao, Pengchi Deng*, Zhipeng Yu,* titled "Direct ring-strain loading for visible-light accelerated bioorthogonal ligation via diarylsydnone-dibenzo[b,f][1,4,5]thiadiazepine photo-click reactions" Commun. Chem., 2020, 3, 29. Shichao Jiang, Xueting Wu, Hui Liu, Jiajie Deng, Xiaocui Zhang, Zhuojun Yao, Yuanqin Zheng, Bo Li, and Zhipeng Yu,* titled "Ring-Strain-Promoted Ultrafast Diaryltetrazole–Alkyne Photoclick Reactions Triggered by Visible Light" ChemPhotoChem, 2020, 4, 327–331. Xiaocui Zhang, Xueting Wu, Shichao Jiang, Jingshuo Gao, Zhuojun Yao, Jiajie Deng, Linmeng Zhang and Zhipeng Yu,* titled "Photo-accelerated "click" reaction between diarylsydnones and ring-strained alkynes for bioorthogonal ligation" Chem. Commun., 2019, 55, 7187–7190. Linmeng Zhang, Xiaocui Zhang, Zhuojun Yao, Shichao Jiang, Jiajie Deng, Bo Li, and Zhipeng Yu,* titled "Discovery of Fluorogenic Diarylsydnone-Alkene Photoligation: Conversion of ortho-Dual-Twisted Diarylsydnones into Planar Pyrazolines" J. Am. Chem. Soc., 2018, 140 (24), pp 7390–7394. Carlo P. Ramil, Maoqing Dong, Peng An, Tracey M. Lewandowski, Zhipeng Yu, Laurence J. Miller,* and Qing Lin,* titled "Spirohexene-Tetrazine Ligation Enables Bioorthogonal Labeling of Class B G Protein-Coupled Receptors in Live Cells" J. Am. Chem. Soc., 2017, 139, 13376–13386. Yulin Tian, Marco Paolo Jacinto, Yu Zeng, Zhipeng Yu, Jun Qu, Wenshe R. Liu,* and Qing Lin,* titled "Genetically Encoded 2-Aryl-5-carboxytetrazoles for Site-Selective Protein Photo-Cross-Linking " J. Am. Chem. Soc., 2017, 139, 6078–6081. Carlo P. Ramil, Peng An, Zhipeng Yu , and Qing Lin*, titled "Sequence-specific 2-cyanobenzothiazole ligation " J. Am. Chem. Soc., 2016 , 138, 5499–5502. Zhipeng Yu and Qing Lin*, titled "Design of Spiro[2.3]hex-1-ene, a Genetically Encodable Double-Strained Alkene for Superfast Photoclick Chemistry" J. Am. Chem. Soc., 2014, 136, 4153–4156. Zhipeng Yu, Tymish Y. Ohulchanskyy, Peng An, Paras N. Prasad, and Qing Lin,* titled "Fluorogenic, Two-Photon-Triggered Photoclick Chemistry in Live Mammalian Cells" J. Am. Chem. Soc., 2013, 135, 16766–16769. Zhipeng Yu, Yanchao Pan, Zhiyong Wang, Jiangyun Wang,* Qing Lin,* titled "Genetically Encoded Cyclopropene Directs Rapid, Photoclick-Chemistry-Mediated Protein Labeling in Mammalian Cells" Angew. Chem. Int. Ed., 2012, 51, 10600-10604. Zhipeng Yu, Lok Yin Ho, and Qing Lin*, titled "Rapid, Photoactivatable Turn-On Fluorescent Probes Based on an Intramolecular Photo click Reaction" J. Am. Chem. Soc., 2011, 133, 11912–11915. Zhipeng Yu, Lok Yin Ho, Zhiyong Wang, Qing Lin*, titled "Discovery of new photoactivatable diaryltetrazoles for photoclick chemistry via ‘scaffold hopping’" Bioorg. Med. Chem. Lett., 2011, 21, 5033-5036. Zhipeng Yu, Reyna K. V. Lim, Qing Lin*, titled "Synthesis of Macrocyclic Tetrazoles for Rapid Photoinduced Bioorthogonal 1,3-Dipolar Cycloaddition Reactions" Chem. Eur. J., 2010, 16, 13325-13329. Peng An, Zhipeng Yu and Qing Lin*, titled "Design of oligothiophene-based tetrazoles for laser-triggered photoclick chemistry in living cells" Chem. Commun., 2013, 49, 9920-9922. Peng An, Zhipeng Yu and Qing Lin*, titled "Design and Synthesis of Laser-Activatable Tetrazoles for a Fast and Fluorogenic Red-Emitting 1,3-Dipolar Cycloaddition Reaction" Org. Lett., 2013, 15, 5496–5499.

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