Babey, Anna-Marie - University of New England - School of Science and Technology

个人简介

I obtained my PhD from McGill University in Montreal under the supervision of Prof Roberta Palmour on the development of cellular tolerance to methylxanthines such as theophylline and caffeine. I then moved to New York to undertake post-doctoral research with Prof Gavril Pasternak at the Memorial Sloan-Kettering Cancer Center, investigating the ability of nitric oxide synthase inhibitors to prevent analgesic tolerance to morphine. I subsequently moved to Minneapolis for a research position with Prof Ping-Yee Law to investigate the contribution of different parts of the opioid receptor molecule to agonist efficacy. In 1998 I accepted a position at James Cook University in Townsville QLD where I taught pharmacology, pathophysiology, physiology and neuroscience to pharmacy, medicine, nursing, biomedical science, science, physiotherapy and dentistry students. I joined the Pharmacy program at UNE at the start of October 2011.

研究领域

Research Interests My research interests include the changes to signal transduction systems that underlie the development of tolerance to opioid analgesics and caffeine as well as drug discovery screening of novel anti-tumour compounds. In addition I have an ongoing interest in Lesch-Nyhan syndrome, an X-linked genetic deficiency of the enzyme hypoxanthine phosphoribosyltransferase that manifests with gouty arthritis, spasticity and self-mutilatory episodes in affected children. tolerance and dependence signal transduction drugs of abuse and addiction drug discovery Lesch-Nyhan syndrome

近期论文

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Ola A.R.B., Babey AM., Motti C. and Bowden B., Aplysiols C–E, brominated triterpene polyethers from the marine alga Chondria armata and a revision of the structure of aplysiol B. Australian Journal of Chemistry, 63(6):907-914, (2010). Cavalli A., Babey AM. and Loh H.H., Altered adenylyl cyclase responsiveness subsequent to point mutations of Asp 128 in the third transmembrane domain of the delta-opioid receptor. Neuroscience. 93(3):1025-1031, (1999). Kolesnikov Y.A., Pan Y.X., Babey AM., Jain S., Wilson R. and Pasternak G.W., Functionally differentiating two neuronal nitric oxide synthase isoforms through antisense mapping: evidence for opposing NO actions on morphine analgesia and tolerance. Proc Natl Acad Sci (USA). 94(15):8220-8225, (1997).