Wilkinson, Brendan - University of New England - School of Science and Technology

个人简介

BSc (Hons) Griffith University 2003. PhD Griffith University 2007. EPSRC Post-doctoral research associate, University of Oxford 2007-09. Post-doctoral research associate, The University of Sydney, 2009-12 Discovery Early Career Research Fellow, Monash University, 2013-2016. Lecturer in organic chemistry, The University of New England, 2016-present.

研究领域

Research Interests 1. Carbohydrate biomaterials Synthesis and biomedical applications of photo-switchable carbohydrate-based surfactants and hydrogels. Glycopeptide dendrimers and PDIs as therapeutic and antifreeze agents. 2. Organic synthesis and functional supramolecular materials Dynamic combinatorial chemistry as a tool for the discovery of new chiral catalysts. Template-directed synthesis of cyclodextrin mimics for drug delivery. 3. Bioorganic and medicinal chemistry Rational development of carbohydrate-based cryoprotectants. Dynamic combinatorial chemistry as a tool for screening peptide based therapeutics. Carbohydrate and glycopeptide-based vaccines for neglected tropical diseases. Our group is interested in the design and synthesis of responsive carbohydrate biomaterials and their biomedical applications. Current areas of research include redox- and photo-responsive sugar surfactants and hydrogels as intelligent drug delivery vectors, self-assembled nanomaterials including glycodendrimers and biofunctionalised perylene diimide dyes as potential therapeutic agents, vaccines and antifreeze agents. We are also interested in developing adaptable carbohydrate and glycopeptide macrocycles as potential drug carriers. Our group collaborates with a number of prominent researchers, including Prof. Robert Ben (Ottawa), Prof. Charl Faul (Bristol), Assoc. Prof. Helen Blanchard (Griffith) and Prof. Vipul Bansal (RMIT).

近期论文

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Adam, M. K.; Poisson, J.; Hu, Y.; Prasannakumar, G.; Pottage, M. J.; Ben, R. N.; Wilkinson, B. L. RSC Adv. 2016, 6, 39240-39244. Hu, Y.; Marlow, J. B.; Ramanathan, R.; Zou, W.; Tiew, H. G.; Pottage, M. J.; Bansal, V.; Tabor, R. F.; Wilkinson, B. L. Synthesis and Properties of Photoswitchable Carbohydrate Fluorosurfactants, Aust. J. Chem. 2015, 68, 1880-1884. Suthagar, K.; Watson, J. A.; Wilkinson, B. L.; Fairbanks, A. J. Synthesis of arabinose glycosyl sulfamides as potential inhibitors of mycobacterial cell wall biosynthesis, Eur. J. Med. Chem. 2015, 102, 153-166. Reeks, T.; Jones, A., Brust, A., Sridharan, S., Corcilius, L., Wilkinson, B. L., Thaysen-Andersen, M., Payne, P. J., Kini, R. M., Daly, N. L., Alewood, P. F. A bifunctional O-glycosylated natriuretic peptide, TcNP-a, from the venom of Tropidechis carinatus has a defined alpha helix, Angew. Chem. Int. Ed. 2015, 54, 4828-4831. Hu, Y., Tabor, R. F., Wilkinson, B. L. Sweetness and Light – design and application of photoswitchable glycoconjugates, Org. Biomol. Chem. 2015, 13, 2216-2225. Ludeman, J. P., Nazari-Robati, M., Wilkinson, B. L., Huang, C., Payne, R. J., Stone, M. J., Phosphate Modulates Receptor Sulfotyrosine Recognition by the Chemokine Monocyte Chemoattractant Protein-1 (MCP-1/CCL2), Org. Biomol. Chem. 2015, 13, 2162-2169. Tabor, R. F., Pottage, M. J., Garvey, C. J., Wilkinson, B. L. Light-induced structural evolution of carbohydrate-based surfactant micelles, Chem. Commun. 2015, 51, 5509-5512. Tabor, R. F., Tan, D. D., Han, S. S., Young, S. A., Seeger, Z. L. E., Pottage, M. J., Garvey, C. J., Wilkinson, B. L. Reversible pH- and photo-controllable carbohydrate-based surfactants, Chem. Eur. J. 2014, 20, 13881-13884. McDonald, D. M., Wilkinson, B. L., Corcilius, L., Thaysen-Andersen, M., Byrne, S. N., Payne. R. J. Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates. Chem. Commun. 2014, 50, 10273-10276. Huma, Z. E., Ludeman, J. P., Wilkinson, B. L., Payne, R. J., Stone, M. J. NMR characterization of cooperativity: Fast ligand binding coupled to slow protein dimerization. Chem. Sci. 2014, 5, 2783-2788. Hsieh, Y.S.Y., Wijeyewickrema, L. C., Wilkinson, B. L., Pike, R. N., Payne, R. J. Total synthesis of homogeneous variants of hirudin P6: A post-translationally modified anti-thrombotic leech-derived protein. Angew.Chem. Int. Ed. 2014, 53 (15), 3947-3951. Al Sheikha, D., Wilkinson, B. L., Santhakumar, G., Thaysen-Andersen, M., Payne, R. J. Synthesis of homogeneous MUC1 oligomers via a bi-directional ligation strategy. Org. Biomol. Chem. 2013, 11, 6090-6096. Roche, M., Halimi, S., Duncan, R.,Wilkinson, B. L. et. al. A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations. Retrovirology 2013, 10 (43), 1-20. Wilkinson, B. L. 1-(Acyloxy)benzotriazoles: Useful Reagents for the Regioselective Acylation of Diols. Aust. J. Chem. 2013, 66 (8), 910-912. Wilkinson, B. L., Day, S., Chapman, R., Perrier, S., Apostolopoulos, V., Payne, R. J. Synthesis and immunological evaluation of self-assembling and self-adjuvanting tricomponent glycopeptide cancer-vaccine candidates. Chem. Eur. J. 2012, 18 (51), 16540-16548. Hsieh, Y. S. Y., Taleski, D., Wilkinson, B. L., Wijeyewickrema, L. C., Adams, T. E., Pike, R. N., Payne, R. J. Role of O-Glycosylation and Tyrosine Sulfation on Leech-Derived Peptides for Binding and Inhibitory Activity against Thrombin. Chem. Commun. 2012, 48, 1547-1549. Hsieh, Y.S.Y., Wilkinson, B. L., O'Connell, M. R., MacKay, J. P., Matthews, J. M., Payne, R. J. Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants. Org. Lett. 2012, 14 (7), 1910-1913. Moeker, J., Teruya, K., Rossit, S., Wilkinson, B. L., Lopez, M., Bornaghi, L. F., Innocenti, A., Supuran, C. T., Poulsen, S. –A. Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases. Bioorg. Med. Chem. 2012, 20 (7), 2392-2404. Wilkinson, B. L. Stone, R. S., Capicciotti, C. J. Thaysen-Andersen, M., Matthews, J. M., Packer, N. H., Ben, R. N., Payne, R. J. Total synthesis of homogeneous antifreeze glycopeptides and glycoproteins. Angew. Chem. 2012, 51 (15), 3606-3610. Wilkinson, B. L., Day, S., Malins, L., Apostolopoulos, V., Payne, R. J.Self-adjuvanting Multi-component Cancer Vaccine Candidates Combining Per-glycosylated MUC1 Glycopeptides and the Toll-like Receptor 2 Agonist Pam3CysSer. Angew. Chem. Int. Ed. 2011, 50, 1635-1639.