Moens, Pierre - University of New England - School of Science and Technology

个人简介

My interest for research began during my bachelor in Physical education (1984-1988) at the Catholic University in Belgium thanks to Professor G. Maréchal my Physiology teacher. This initial interest further developed during my MSc (1990) and PhD (1993) when I investigated the function of Dystrophin in a murine model of the Duchenne Muscular Dystrophy. My PhD was followed by a first postdoctoral position in Professor Cris dos Remedios laboratory at the University of Sydney. Cris introduced me to the wonderful world of fluorescence spectroscopy. In 1998, I returned to Europe for two years at the University of Bordeaux in France. This period in Europe gave me the opportunity to learn molecular biology techniques. I then joined the laboratory of Prof. David M Jameson in Hawaii in 2000. In his laboratory, I established a molecular biology section and broadened and deepened my knowledge on the application of fluorescence to biological systems. I arrived at the University of New England in April of 2003 where I started my academic career.

研究领域

Research Interests I have a continued interest in understanding the molecular basis and the dynamics of protein interaction. My current research focuses on the motility of non-muscle cells. Particularly in the signaling pathway linking the membrane receptors to the cytoskeleton and the role of this pathway in human cancer.

近期论文

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P.D.J. Moens and L.A. Bagatolli, Profilin binding to sub-micellar concentrations of phosphatidylinositol (4,5) bisphosphate and phosphatidylinositol (3,4,5) trisphosphate, Biochimica Biophysica Acta, vol. 1768, pp. 439-449, 2007. Moens P. D. J., Wahl M. C. and Jameson D. M., Oligomeric State and Mode of Self-Association of Thermotoga maritima Ribosomal Stalk Protein L12 in Solution, Biochemistry, vol. 44, pp. 3298-3305, 2005. Jameson D. M., Croney J. C. and Moens P. D., J. Fluorescence: basic concepts, practical aspects, and some anecdotes, Methods Enzymol, vol. 360, pp. 1-43, 2003. Moens P. D. and dos Remedios C. G., A conformational change in F-actin when myosin binds: fluorescence resonance energy transfer detects an increase in the radial coordinate of Cys-374, Biochemistry, vol. 36, pp. 7353-7360, 1997. M. Kekic, W. Huang, P.D. Moens, B.D. Hambly and C.G. dos Remedios, Distance measurements near the myosin head-rod junction using fluorescence spectroscopy, Biophys J, vol. 71, pp. 40-47, 1996. Moens P. D., Van-Schoor M. C. and Marechal G., Lack of myoblasts migration between transplanted and host muscles of mdx and normal mice, J Muscle Res Cell Motil, vol. 17, pp. 37-43, 1996. dos Remedios C. G. and Moens P. D., Fluorescence resonance energy transfer spectroscopy is a reliable "ruler" for measuring structural changes in proteins. Dispelling the problem of the unknown orientation factor, J Struct Biol, vol. 115, pp. 175-185, 1995. dos Remedios C. G. and Moens P. D., Actin and the actomyosin interface: a review, Biochim Biophys Acta, vol. 1228, pp. 99-124, 1995. Moens P. D., Yee D. J. and dos Remedios C. G., Determination of the radial coordinate of Cys-374 in F-actin using fluorescence resonance energy transfer spectroscopy: effect of phalloidin on polymer assembly, Biochemistry, vol. 33, pp. 13102-13108, 1994. Moens P., Baatsen P. H. and Marechal G., Increased susceptibility of EDL muscles from mdx mice to damage induced by contractions with stretch, J Muscle Res Cell Motil, vol. 14, pp. 446-451, 1993.