Gedye, Craig - University of Newcastle - School of Biomedical Sciences and Pharmacy

研究领域

I am a physician/scientist, dual trained as a medical oncologist and as a basic science cancer researcher. I am inspired by working for patients with melanoma, brain, prostate, bladder and kidney cancers at the Calvary Mater Newcastle. I undertake clinical, translational and basic cancer research at the University of Newcastle/HMRI which is supported by the Hunter Cancer Research Alliance. My research focuses on complexity in cancer, with a particular interest in understanding "intratumoural heterogeneity". In every patient, every cancer cell is a bit different to every other cancer cell. Some cancer cells seem to be able to spread and cause trouble; others are less aggressive. What determines these differences? Can we exploit them to target cancer cells that are behaving differently? Between different patients, cancers that come from the same organ can behave completely differently, and treatments that help one patient fail the next. Why is this? Why does a cancer lie dormant, then come back? Why does treatment not work in some patients, or work for a time, then fail? These questions are incredibly important, as we seek to find the treatments that work best for each individual patient. We will do this by using existing treatments more cleverly, as well as by discovering new treatments.

近期论文

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2016 Gedye C, Sirskyj D, Lobo NC, Meens J, Hyatt E, Robinette M, et al., 'Cancer stem cells are underestimated by standard experimental methods in clear cell renal cell carcinoma', Scientific Reports, 6 (2016) [C1] 2016 Gedye C, Fleming J, 'Forsaking cures for cancer: why are we discarding the tumour biospecimens of most patients?', Med J Aust, 204 297-298 (2016) 2016 Gedye C, Cardwell T, Dimopoulos N, Tan BS, Jackson H, SvobodovÃ¡ S, et al., 'Mycoplasma Infection Alters Cancer Stem Cell Properties in Vitro', Stem Cell Reviews and Reports, 12 156-161 (2016) 2016 Khoja L, Atenafu EG, Ye Q, Gedye C, Chappell M, Hogg D, et al., 'Real-world efficacy, toxicity and clinical management of ipilimumab treatment in metastatic melanoma.', Oncol Lett, 11 1581-1585 (2016) 2016 Lobo NC, Gedye C, Apostoli AJ, Brown KR, Paterson J, Stickle N, et al., 'Efficient generation of patient-matched malignant and normal primary cell cultures from clear cell renal cell carcinoma patients: Clinically relevant models for research and personalized medicine', BMC Cancer, 16 (2016) 2016 Chia PL, Gedye C, Boutros PC, Wheatley-Price P, John T, 'Current and Evolving Methods to Visualize Biological Data in Cancer Research.', J Natl Cancer Inst, 108 (2016) 2016 Gedye C, 'BIOMARKERS IN RENAL CELL CARCINOMA: THE TRIANGLE OR THE ORCHESTRA?', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 12 31-31 (2016) 2015 Gedye C, Boyle FM, 'Optimising treatment for Australian melanoma patients can save taxpayers millions of dollars annually', The Medical journal of Australia, 202 130 (2015) [C3] 2015 Gedye C, van der Westhuizen A, John T, 'Checkpoint immunotherapy for cancer: superior survival, unaccustomed toxicities.', Intern Med J, 45 696-701 (2015) [C1] 2014 Gedye C, Hogg D, Butler M, Joshua AM, 'New treatments for metastatic melanoma', CANADIAN MEDICAL ASSOCIATION JOURNAL, 186 754-760 (2014) 2014 Naert K, Al Habeeb A, Gedye C, Ghazarian D, 'Targeted therapy in melanoma: The era of personalized medicine', Diagnostic Histopathology, (2014) [C1] 2014 Gedye CA, Hussain A, Paterson J, Smrke A, Saini H, Sirskyj D, et al., 'Cell Surface Profiling Using High-Throughput Flow Cytometry: A Platform for Biomarker Discovery and Analysis of Cellular Heterogeneity', PLOS ONE, 9 (2014) 2013 Kurban G, Gedye C, Morales C, Yousef GM, Almatar A, Jewett MAS, 'DIAGNOSIS AND TREATMENT OF SMALL RENAL MASSES: THE ROLE FOR MOLECULAR BIOLOGY', ARCHIVOS ESPANOLES DE UROLOGIA, 66 505-516 (2013) [C1] 2013 Gedye C, Ailles L, 'Isolation and characterization of cancer stem cells in vitro', Methods in Molecular Biology, 946 181-204 (2013) [B2] 2013 Behren A, Anaka M, Lo P-H, Vella LJ, Davis ID, Catimel J, et al., 'The Ludwig Institute for Cancer Research Melbourne Melanoma Cell Line Panel', PIGMENT CELL & MELANOMA RESEARCH, 26 (2013) 2013 Reaume MN, Graham GE, Tomiak E, Kamel-Reid S, Jewett MAS, Bjarnason GA, et al., 'Canadian guideline on genetic screening for hereditary renal cell cancers', CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL, 7 319-323 (2013) 2013 Trapani JA, Thia KYT, Andrews M, Davis ID, Gedye C, Parente P, et al., 'Human perforin mutations and susceptibility to multiple primary cancers', ONCOIMMUNOLOGY, 2 (2013) 2012 Neel BG, Stewart JM, Bodenmiller B, Ailles L, Gedye C, Bernardini M, et al., 'Phenotypic heterogeneity and instability of human serous ovarian cancer tumor-initiating cells', CANCER RESEARCH, 72 (2012) 2012 Anaka M, Freyer C, Gedye C, Caballero O, Davis ID, Behren A, Cebon J, 'Stem Cell Media Culture of Melanoma Results in the Induction of a Nonrepresentative Neural Expression Profile', STEM CELLS, 30 336-343 (2012) [C3] 2011 Stewart JM, Shaw PA, Gedye C, Bernardini MQ, Neel BG, Ailles LE, 'Phenotypic heterogeneity and instability of human ovarian tumor-initiating cells', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108 6468-6473 (2011) [C1]