个人简介

Dr Kirsty Pringle is a Research Fellow in the Mothers and Babies Research Centre at the Hunter Medical Research Institute and is part of the Priority Research Centre for Reproductive Sciences. Dr Pringle’s current research examines the role of the intrauterine, circulating and intrarenal renin angiotensin systems (RASs) in pregnancy. With Professor Eugenie Lumbers she has helped to set up and now successfully manages a research team at the University of Newcastle. Her recent publications, NHMRC grant success (as CIA) and invitations to present at international meetings in highly specialised areas attests to her dedication to the field and highlights her research output. Dr Pringle is now successfully coordinating a productive research team, supervising postgraduate students and working and collaborating independently. Dr Pringle has a BSc (Hons) and PhD in Obstetrics and Gynaecology from the University of Adelaide (2008). During her postgraduate studies Dr Pringle research focused on the molecular regulators of placentation.

研究领域

Pharmacy and Experimental Pharmacology

The use of markers of the circulating and intrarenal RAS to identify Indigenous women with underlying kidney disease and who are potentially at risk of preeclampsia or SGA (Kirsty is CIA on an NHMRC project grant with Lumbers, Rae, Broughton-Pipkin & Smith). MicroRNAs that regulate the placental renin angiotensin system and how these impact placental angiogenesis and pregnancy outcome; Components of the circulating renin angiotensin system as novel early biomarkers of adverse pregnancy outcomes such as preeclampsia and gestational hypertension; Novel actions of Angiotensin II in the circulation of the preterm neonate and implications for clinical management of preterm cardiovascular compromise; and The role of the endometrial RAS in endometrial cancer and endometriosis and the potential that RAS blocking drugs could be used to treat these diseases.

近期论文

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2016 Pringle KG, Delforce SJ, Wang Y, Ashton KA, Proietto A, Otton G, et al., 'Renin-angiotensin system gene polymorphisms and endometrial cancer.', Endocr Connect, 5 128-135 (2016) 2016 Ashman AM, Collins CE, Weatherall L, Brown LJ, Rollo ME, Clausen D, et al., 'A cohort of Indigenous Australian women and their children through pregnancy and beyond: the Gomeroi gaaynggal study.', J Dev Orig Health Dis, 7 357-368 (2016) 2016 Grimson S, Cox AJ, Pringle KG, Burns C, Lumbers ER, Blackwell CC, Scott RJ, 'The prevalence of unique SNPs in the renin-angiotensin system highlights the need for pharmacogenetics in Indigenous Australians', Clinical and Experimental Pharmacology and Physiology, 43 157-160 (2016) 2016 Delforce SJ, Wang Y, Van-Aalst ME, Corbisier De Meaultsart C, Morris BJ, Broughton-Pipkin F, et al., 'Effect of oxygen on the expression of renin-angiotensin system components in a human trophoblast cell line', Placenta, 37 1-6 (2016) 2015 Wang Y, Lumbers ER, Sykes SD, Pringle KG, 'Regulation of the renin-angiotensin system pathways in the human decidua', Reproductive Sciences, 22 865-872 (2015) [C1] 2015 Pringle KG, Conquest A, Mitchell C, Zakar T, Lumbers ER, 'Effects of Fetal Sex on Expression of the (Pro)renin Receptor and Genes Influenced by its Interaction With Prorenin in Human Amnion', Reproductive Sciences, 22 750-757 (2015) [C1] 2015 Pringle KG, Wang Y, Lumbers ER, 'The synthesis, secretion and uptake of prorenin in human amnion.', Physiological reports, 3 (2015) [C1] 2015 Sykes SD, Mitchell C, Pringle KG, Wang Y, Zakar T, Lumbers ER, 'Methylation of promoter regions of genes of the human intrauterine renin angiotensin system and their expression', International Journal of Endocrinology, 2015 (2015) [C1] 2015 Pringle KG, Weatherall L, Corbisier de Meaultsart C, Keogh L, Sands S, Blackwell C, et al., 'The Gomeroi Gaaynggal Cohort: A Preliminary Study of the Maternal Determinants of Pregnancy Outcomes in Indigenous Australian Women', Journal of Pregnancy and Child Health, 3 (2015) [C1] 2015 Pringle KG, Rae K, Weatherall L, Hall S, Burns C, Smith R, et al., 'Effects of maternal inflammation and exposure to cigarette smoke on birth weight and delivery of preterm babies in a cohort of Indigenous Australian women', Frontiers in Immunology, 6 (2015) [C1] 2015 Lumbers ER, Wang Y, Delforce SJ, Corbisier de Meaultsart C, Logan PC, Mitchell MD, Pringle KG, 'Decidualisation of human endometrial stromal cells is associated with increased expression and secretion of prorenin', Reproductive Biology and Endocrinology, 13 (2015) [C1] 2015 Pringle KG, Sykes SD, Lumbers ER, 'Circulating and intrarenal renin-angiotensin systems in healthy men and nonpregnant women.', Physiol Rep, 3 (2015) [C1] 2015 Standen P, Sferruzzi-Perri AN, Taylor R, Heinemann G, Zhang JV, Highet AR, et al., 'Maternal insulin-like growth factor 1 and 2 differentially affect the renin-angiotensin system during pregnancy in the guinea pig', GROWTH HORMONE & IGF RESEARCH, 25 141-147 (2015) [C1] 2014 Sykes SD, Pringle KG, Zhou A, Dekker GA, Roberts CT, Lumbers ER, SCOPE Consortium, 'The balance between human maternal plasma angiotensin II and angiotensin 1-7 levels in early gestation pregnancy is influenced by fetal sex.', J Renin Angiotensin Aldosterone Syst, 15 523-531 (2014) [C1] 2014 Lumbers ER, Pringle KG, 'Roles of the circulating renin-angiotensin-aldosterone system in human pregnancy', AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 306 R91-R101 (2014) [C1] 2014 Sykes SD, Pringle KG, Zhou A, Dekker GA, Roberts CT, Lumbers ER, 'Fetal sex and the circulating renin-angiotensin system during early gestation in women who later develop preeclampsia or gestational hypertension', Journal of Human Hypertension, 28 133-139 (2014) [C1] 2014 Rae KM, Weatherall L, Blackwell CC, Pringle K, Smith R, Lumbers E, 'Long conversations: Gomeroi gaaynggal tackles renal disease in the Indigenous community', Australasian Epidemiologist, 21 44-48 (2014) [C2] 2013 Wang Y, Pringle KG, Lumbers ER, 'The effects of cyclic AMP, sex steroids and global hypomethylation on the expression of genes controlling the activity of the renin-angiotensin system in placental cell lines', PLACENTA, 34 275-280 (2013) [C1] 2013 Mitchell CM, Sykes SD, Pan X, Pringle KG, Lumbers ER, Hirst JJ, Zakar T, 'Inflammatory and steroid receptor gene methylation in the human amnion and decidua', JOURNAL OF MOLECULAR ENDOCRINOLOGY, 50 267-277 (2013) [C1] 2013 Lumbers ER, Pringle KG, Wang Y, Gibson KJ, 'The renin-angiotensin system from conception to old age: the good, the bad and the ugly', CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 40 743-752 (2013) [C1]