个人简介

Dr Hua (BPharm, Hons, PhD, MPS) has been a full-time teaching and research (T&R) academic at the School of Biomedical Sciences and Pharmacy since 2010. She is a registered pharmacist in Australia and has several years’ experience across various facets of pharmacy, including hospital, community and research. Dr Hua has a Bachelor of Pharmacy degree and a PhD from The University of Queensland in the field of neuroscience and nanotechnology. Since her appointment at The University of Newcastle, Dr Hua has independently established a translational nanopharmaceutics laboratory and research program focused on therapeutic targeting using nanotechnology. Her background as a clinical pharmacist has given her a thorough clinical understanding of therapeutics and disease states, and has allowed her to identify promising research avenues in therapeutics and drug delivery.

研究领域

Pharmacy and Experimental Pharmacology

The general research focus of Dr Hua's laboratory is on therapeutic targeting utilising novel drug delivery platforms in biomedical applications. She is particularly interested in using nanotechnology to study novel mechanistic pathways, as well as to develop more efficient therapeutic delivery systems. For example, a number of her key projects are focused on translational pain research in the areas of peripheral analgesia and inflammation. Dr Hua has established important animal models of acute and chronic pain at The University of Newcastle, including the AIA and MIA rodent models of chronic arthritis, and the CFA rodent model of acute inflammatory pain. Her research expertise covers the areas of advanced pharmaceutical formulation, in vitro cellular studies and preclinical in vivo animal studies. This expertise provides a solid foundation to formulate and evaluate new drug delivery systems and to apply them to pathological disease states, in order to assess potential clinical applicability and identify novel therapeutic targets. Dr Hua’s research provides a platform for the translational development of targeted therapeutics that will ultimately provide a novel therapeutic strategy in clinical disease management.

近期论文

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2016 Stone T, Hua S, Turale S, 'Evaluation of an international and interprofessional collaboration forum', Nurse Education Today, 46 10-16 (2016) 2016 Hua S, 'Neuroimmune Interaction in the Regulation of Peripheral Opioid-Mediated Analgesia in Inflammation.', Front Immunol, 7 293 (2016) 2016 Hua S, Dias TH, 'Hypoxia-Inducible Factor (HIF) as a target for novel therapies in rheumatoid arthritis', Frontiers in Pharmacology, 7 (2016) 2016 Hua S, Cook D, Walker MM, Talley NJ, 'Pharmacological treatment of eosinophilic gastrointestinal disorders.', Expert Rev Clin Pharmacol, 9 1195-1209 (2016) 2016 Paul JW, Hua S, Ilicic M, Tolosa JM, Butler T, Smith R, 'Drug Delivery to the Human and Mouse Uterus using Immunoliposomes Targeted to the Oxytocin Receptor.', Am J Obstet Gynecol, (2016) 2016 Mateer SW, Cardona J, Marks E, Goggin BJ, Hua S, Keely S, 'Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease.', J Vis Exp, e53250 (2016) 2015 Sercombe L, Veerati T, Moheimani F, Wu SY, Sood AK, Hua S, 'Advances and challenges of liposome assisted drug delivery', Frontiers in Pharmacology, 6 (2015) [C1] 2015 Hua S, Marks E, Schneider JJ, Keely S, 'Advances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: selective targeting to diseased versus healthy tissue.', Nanomedicine, 11 1117-1132 (2015) [C1] 2015 Hua S, 'Lipid-based nano-delivery systems for skin delivery of drugs and bioactives.', Frontiers in pharmacology, 6 219 (2015) [C1] 2014 Jobling P, O'Hara K, Hua S, 'Female reproductive tract pain: Targets, challenges, and outcomes', Frontiers in Pharmacology, 5 FEB (2014) [C1] 2014 Hua S, 'Comparison of in vitro dialysis release methods of loperamide-encapsulated liposomal gel for topical drug delivery', International Journal of Nanomedicine, 9 735-744 (2014) [C1] 2014 Iwaszkiewicz KS, Hua S, 'Development of an effective topical liposomal formulation for localized analgesia and antiinflammatory actions in the Complete Freund¿s Adjuvant rodent model of acute inflammatory pain', Pain Physician, 17 E719-E735 (2014) [C1] 2014 Hua S, Cabot PJ, 'PAIN - Novel targets and new technologies', Frontiers in Pharmacology, 5 (2014) [C3] 2014 Hua S, 'Orally administered liposomal formulations for colon targeted drug delivery', Frontiers in Pharmacology, 5 JUN 1-4 (2014) [C2] 2013 Hua S, 'Targeting sites of inflammation: intercellular adhesion molecule-1 as a target for novel inflammatory therapies.', Front Pharmacol, 4 127 (2013) [C1] 2013 Hua S, Wu SY, 'The use of lipid-based nanocarriers for targeted pain therapies', Frontiers in Pharmacology, 4 NOV (2013) [C1] 2013 Iwaszkiewicz KS, Schneider JJ, Hua S, 'Targeting peripheral opioid receptors to promote analgesic and anti-inflammatory actions.', Front Pharmacol, 4 132 (2013) [C1] 2013 Hua S, Cabot PJ, 'Targeted Nanoparticles that Mimic Immune Cells in Pain Control Inducing Analgesic and Anti-inflammatory Actions: A Potential Novel Treatment of Acute and Chronic Pain Conditions', PAIN PHYSICIAN, 16 E199-E216 (2013) [C1] 2011 Witting PK, Song C, Hsu K, Hua S, Parry SN, Rye K, et al., 'The acute phase protein serum amyloid A induces endothelial dysfunction that is inhibited by high-density lipoprotein.', Free Radical Biology and Medicine, 51 1390-1398 (2011) [C1] 2011 Hua S, Chang H-I, Davies N, Cabot PJ, 'Targeting of ICAM-1-directed immunoliposomes specifically to activated endothelial cells with low cellular uptake: use of an optimized procedure for the coupling of low concentrations of antibody to liposomes.', Journal of Liposome Research, 21 95-105 (2011) [C1]