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研究领域

Pharmacy and Experimental Pharmacology

Molecular and cellular biology. High throughput genomics, bioinformatics and systems biology. Biology of non-coding RNA and post transcriptional gene regulation. Expertise in these areas was developed to investigate mechanisms for gene regulation in neurodevelopment and their role in complex neuropsychiatric disorders.

近期论文

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2016 Zhang X, Gee H, Rose B, Lee CS, Clark J, Elliott M, et al., 'Regulation of the tumour suppressor PDCD4 by miR-499 and miR-21 in oropharyngeal cancers', BMC Cancer, 16 (2016) [C1] 2016 Giacomotto J, Carroll AP, Rinkwitz S, Mowry B, Cairns MJ, Becker TS, 'Developmental suppression of schizophrenia-associated miR-137 alters sensorimotor function in zebrafish.', Translational psychiatry, 6 e818 (2016) [C1] 2016 Hollins SL, Cairns MJ, 'MicroRNA: Small RNA mediators of the brains genomic response to environmental stress.', Prog Neurobiol, 143 61-81 (2016) 2016 Hollins SL, Zavitsanou K, Walker FR, Cairns MJ, 'Alteration of transcriptional networks in the entorhinal cortex after maternal immune activation and adolescent cannabinoid exposure', Brain, Behavior, and Immunity, 56 187-196 (2016) 2016 Hess JL, Tylee DS, Barve R, de Jong S, Ophoff RA, Kumarasinghe N, et al., 'Transcriptome-wide mega-analyses reveal joint dysregulation of immunologic genes and transcription regulators in brain and blood in schizophrenia', Schizophrenia Research, (2016) 2016 Mehta D, Tropf FC, Gratten J, Bakshi A, Zhu Z, Bacanu SA, et al., 'Evidence for Genetic Overlap Between Schizophrenia and Age at First Birth in Women.', JAMA Psychiatry, 73 497-505 (2016) 2016 Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, van Hulzen KJE, et al., 'Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept', Nature Neuroscience, (2016) 2015 Dun MD, Chalkley RJ, Faulkner S, Keene S, Avery-Kiejda KA, Scott RJ, et al., 'Proteotranscriptomic profiling of 231-BR breast cancer cells: Identification of potential biomarkers and therapeutic targets for brain metastasis', Molecular and Cellular Proteomics, 14 2316-2330 (2015) [C1] 2015 Cairns MJ, 'Circulating miRNA biomarkers for schizophrenia?', American Journal of Psychiatry, 172 1059-1061 (2015) [C3] 2015 Quinn RK, Brown AL, Goldie BJ, Levi EM, Dickson PW, Smith DW, et al., 'Distinct miRNA expression in dorsal striatal subregions is associated with risk for addiction in rats', Translational Psychiatry, 5 (2015) [C1] 2015 Bulik-Sullivan B, Loh PR, Finucane HK, Ripke S, Yang J, Patterson N, et al., 'LD score regression distinguishes confounding from polygenicity in genome-wide association studies', Nature Genetics, 47 291-295 (2015) [C1] 2015 Bergon A, Belzeaux R, Comte M, Pelletier F, Hervé M, Gardiner EJ, et al., 'CX3CR1 is dysregulated in blood and brain from schizophrenia patients', Schizophrenia Research, 168 434-443 (2015) [C1] 2015 Green MJ, Raudino A, Cairns MJ, Wu J, Tooney PA, Scott RJ, Carr VJ, 'Do common genotypes of FK506 binding protein 5 (FKBP5) moderate the effects of childhood maltreatment on cognition in schizophrenia and healthy controls?', Journal of Psychiatric Research, 70 9-17 (2015) [C1] 2015 Wu JQ, Green MJ, Gardiner EJ, Tooney PA, Scott RJ, Carr VJ, Cairns MJ, 'Altered neural signaling and immune pathways in peripheral blood mononuclear cells of schizophrenia patients with cognitive impairment: A transcriptome analysis', Brain, Behavior, and Immunity, (2015) [C1] 2015 Geaghan M, Cairns MJ, 'MicroRNA and Posttranscriptional Dysregulation in Psychiatry', Biological Psychiatry, 78 231-239 (2015) [C1] 2015 Wang X, Gardiner EJ, Cairns MJ, 'Optimal consistency in microRNA expression analysis using reference-gene-based normalization', MOLECULAR BIOSYSTEMS, 11 1235-1240 (2015) [C1] 2015 Ingason A, Giegling I, Hartmann AM, Genius J, Konte B, Friedl M, et al., 'Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case¿control sample of schizophrenia', Translational Psychiatry, 5 e656-e656 (2015) [C1] 2015 Cropley VL, Scarr E, Fornito A, Klauser P, Bousman CA, Scott R, et al., 'The effect of a muscarinic receptor 1 gene variant on grey matter volume in schizophrenia', Psychiatry Research - Neuroimaging, 234 182-187 (2015) [C1] 2014 Oldmeadow C, Mossman D, Evans TJ, Holliday EG, Tooney PA, Cairns MJ, et al., 'Combined analysis of exon splicing and genome wide polymorphism data predict schizophrenia risk loci.', J Psychiatr Res, 52 44-49 (2014) [C1] 2014 Goldie BJ, Dun MD, Lin M, Smith ND, Verrills NM, Dayas CV, Cairns MJ, 'Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons.', Nucleic Acids Research, 42 9195-9208 (2014) [C1]

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