个人简介

Dr Nikola Bowden was appointed at the University of Newcastle in 2006 as the inaugural NBN Telethon childhood cancer post-doctoral fellow. Subsequent to this in 2008 she was awarded a Gladys M. Brawn memorial post-doctoral fellowship from the Faculty of Health, University of Newcastle. In January 2009 Dr Bowden was appointed as a Lecturer in the School of Biomedical Sciences & Pharmacy and was awarded an NH&MRC training (post-doctoral) fellowship which she commenced in October 2009. Since 2006, Dr Bowden has developed a research interest with the overall aim of delivering personalised diagnosis and treatment to patients with cancer, with a more focused interest in investigating DNA repair in melanoma. Dr Bowden's research has been funded through a nationally competitive fellowship and grants from the NH&MRC, Cure Cancer Australia Foundation and Cancer Australia, respectively. Dr Bowden collaborates with Dr Daniel Catchpoole at the Children’s Hospital at Westmead and has international collaborations with Prof James Cleaver from University of California San Francisco (USA) and Dr Javed Khan from the National Cancer Institute and National Institutes of Health (USA). Dr Bowden has obtained over $1,000,000 in funding, published 22 articles in international peer-reviewed journals and have presented her research over 60 times at international and national conferences. Dr Bowden currently supervises 4 research higher degree PhD students. Dr Bowden was awarded the University of Newcastle Young Alumni Award in 2011 and was part of a collaboration awarded the Schizophrenia Research Institute Research Paper Award in 2008 and was the recipient of the 2007 Hunter Children's Research Foundation (HCRF) Award for Research Excellence for her research into the DNA repair and skin cancer disorder, Xeroderma Pigmentosum, and childhood acute lymphoblastic leukaemia. In 2006, she was awarded the Hunter Medical Research Institute (HMRI) PULSE Education Prize, an award presented to an outstanding early career researcher. Dr Bowden has been an invited reviewer for the international funding body Medical Research Council (UK), and many international journals.

研究领域

Medical Genetics

Below is a summary of my current research projects: Nucleotide Excision Repair Gene Expression in Melanoma: My main research program is investigating the role of DNA repair in cancer. The results of a pilot study into deficient DNA repair in melanoma have been published in the journal Cancer Research. The publication of this manuscript represents a shift in the central dogma surrounding DNA repair and melanoma. To date there has been a central belief that DNA repair is not involved in development of melanoma. The results of our study have now confirmed the hypothesis that a deficiency in DNA repair is indeed a feature of melanoma and may be the reason why melanomas develop after excessive sun exposure and why melanomas do not respond to common chemotherapeutic agents. The major outcome of this research program will be a biological explanation for why excessive sunlight exposure results in melanomagenesis and why melanomas do not respond to common DNA-damaging chemotherapeutic agents, two of the most elusive features of melanoma. In addition, I collaborate with Dr Ricardo Vilain and Dr Stephen Braye from the Hunter Area Pathology Service (HAPS) Anatomocal Pathology department to utilise formalin-fixed paraffin embedded (FFPE) melanoma tissue collected and stored for diagnostic purposes. This tissue represents a very large cohort of individuals from the hunter region with melanoma and allows for retrospective analysis of clinical data such as disease recurrence, response to treatment and survival. Another major advantage of using this tissue is that it requires no direct participation from patients with melanoma thus lessening the burden of research on clinicians and patients. This collaboration was established in 2009 and the preliminary results of several projects have been presented at the 7th and 8th International Congress of the Society for Melanoma Research (2010 & 2011).

近期论文

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2016 Bolton KA, Avery-Kiejda KA, Holliday EG, Attia J, Bowden NA, Scott RJ, 'A polymorphic repeat in the IGF1 promoter influences the risk of endometrial cancer.', Endocr Connect, 5 115-122 (2016) [C1] 2016 Day T, Bowden N, Jaaback K, Otton G, Scurry J, 'Distinguishing erosive lichen planus from differentiated vulvar intraepithelial neoplasia', Journal of Lower Genital Tract Disease, 20 174-179 (2016) [C1] 2016 Murray HC, Maltby VE, Smith DW, Bowden NA, 'Nucleotide excision repair deficiency in melanoma in response to UVA', Experimental Hematology and Oncology, 5 (2016) [C1] 2016 Bowden NA, Smyth M, Jaaback K, Ashton KA, Scurry J, 'Genetic changes correlate with histopathology in a benign, borderline and malignant mucinous ovarian tumour', Journal of Obstetrics and Gynaecology, 36 119-121 (2016) 2016 Bolton KA, Holliday EG, Attia J, Bowden NA, Avery-Kiejda KA, Scott RJ, 'A novel polymorphic repeat in the upstream regulatory region of the estrogen-induced gene EIG121 is not associated with the risk of developing breast or endometrial cancer', BMC Research Notes, 9 (2016) 2016 Davey RJ, Westhuizen AVD, Bowden NA, 'Metastatic melanoma treatment: Combining old and new therapies', Critical Reviews in Oncology/Hematology, 98 242-253 (2016) 2015 Ashton KA, Scurry J, Tabrizi SN, Garland SM, Otton G, Bowden NA, 'The problem of late ovarian metastases from primary cervical adenocarcinoma.', Gynecologic oncology reports, 13 23-25 (2015) [C3] 2015 Bowden NA, Beveridge NJ, Ashton KA, Baines KJ, Scott RJ, 'Understanding xeroderma pigmentosum complementation groups using gene expression profiling after UV-light exposure', International Journal of Molecular Sciences, 16 15985-15996 (2015) [C1] 2014 Evans TJ, Milne E, Anderson D, de Klerk NH, Jamieson SE, Talseth-Palmer BA, et al., 'Confirmation of childhood acute lymphoblastic leukemia variants, ARID5B and IKZF1, and interaction with parental environmental exposures.', PLoS One, 9 e110255 (2014) [C1] 2014 Ashton KA, Scurry J, Ouveysi A, Ebbs J, Jaaback K, Bowden NA, 'Transformation of endometrioid carcinoma to carcinoma with trophoblastic differentiation: clinicopathological and whole genomic study.', Pathology, 46 351-353 (2014) [C3] 2014 Wong-Brown MW, Avery-Kiejda KA, Bowden NA, Scott RJ, 'Low prevalence of germline PALB2 mutations in Australian triple-negative breast cancer', International Journal of Cancer, 134 301-305 (2014) [C1] 2014 Bowden NA, 'Nucleotide excision repair: Why is it not used to predict response to platinum-based chemotherapy?', Cancer Letters, (2014) [C1] 2014 Wan C, Latter JL, Amirshahi A, Symonds I, Finnie J, Bowden N, et al., 'Progesterone Activates Multiple Innate Immune Pathways in Chlamydia trachomatis-Infected Endocervical Cells', American Journal of Reproductive Immunology, 71 165-177 (2014) [C1] 2014 Cox MB, Bowden NA, Scott RJ, Lechner-Scott J, 'Common genetic variants in the plasminogen activation pathway are not associated with multiple sclerosis', Multiple Sclerosis Journal, 20 489-491 (2014) [C1] 2013 Cox MB, Bowden NA, Scott RJ, Lechner-Scott J, 'Altered expression of the plasminogen activation pathway in peripheral blood mononuclear cells in multiple sclerosis: possible pathomechanism of matrix metalloproteinase activation', Multiple Sclerosis Journal, 19 1268-1274 (2013) [C1] 2013 Budden T, Bowden NA, 'The Role of Altered Nucleotide Excision Repair and UVB-Induced DNA Damage in Melanomagenesis', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 14 1132-1151 (2013) [C1] 2013 Bolton KA, Ross JP, Grice DM, Bowden NA, Holliday EG, Avery-Kiejda KA, Scott RJ, 'STaRRRT: a table of short tandem repeats in regulatory regions of the human genome', BMC GENOMICS, 14 (2013) [C1] 2013 Bowden NA, Ashton KA, Vilain RE, Avery-Kiejda KA, Davey RJ, Murray HC, et al., 'Regulators of Global Genome Repair Do Not Respond to DNA Damaging Therapy but Correlate with Survival in Melanoma', PLOS ONE, 8 (2013) [C1] 2012 Ashton KA, Scurry JP, Rutherford J, Otton GR, Scott R, Bowden NA, 'Nodular prurigo of the vulva', Pathology, 44 565-567 (2012) [C3] 2012 Young KMN, Scurry JP, Jaaback KS, Bowden NA, Scott R, 'Bilateral dysgerminoma associated with gonadoblastoma and sex-cord stromal tumour with annular tubules in a 28-year-old fertile woman with normal karyotype', Pathology, 44 257-260 (2012) [C3]