研究领域

Immunology and Microbiology

Professor Phil Hansbro is an internationally recognised research leader in the study of respiratory diseases, such as asthma, chronic obstructive airway disease (COPD, aka emphysema) and infections and is developing interests in lung cancer. His work is substantially contributing to understanding the pathogenesis and developing new therapies for these diseases. Indeed his work has made internationally important contributions and led to the identification of novel avenues for therapy that are under further study. This is achieved through the development of novel mouse models that recapitulate the hallmark features of human disease, including infections, asthma and COPD and now lung cancer. He employs these models in integrated approaches (infection, immunity & physiology with particular expertise in lung function analysis) to understand human diseases, and develop new treatment strategies. Research outcomes have a translational goal and his studies are conducted in parallel with collaborative human studies with clinical researchers

近期论文

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2016 Ren S, Hure A, Peel R, D'Este C, Abhayaratna W, Tonkin A, et al., 'Rationale and design of a randomized controlled trial of pneumococcal polysaccharide vaccine for prevention of cardiovascular events: The Australian Study for the Prevention through Immunization of Cardiovascular Events (AUSPICE)', American Heart Journal, 177 58-65 (2016) 2016 Russell KE, Chung KF, Clarke CJ, Durham AL, Mallia P, Footitt J, et al., 'The MIF antagonist ISO-1 attenuates corticosteroid-insensitive inflammation and airways hyperresponsiveness in an ozone-induced model of COPD', PLoS ONE, 11 (2016) [C1] 2016 Simpson JL, Baines KJ, Horvat JC, Essilfie AT, Brown AC, Tooze M, et al., 'COPD is characterized by increased detection of Haemophilus influenzae, Streptococcus pneumoniae and a deficiency of Bacillus species', Respirology, 21 697-704 (2016) [C1] 2016 Hansbro P, Nair P, Starkey M, Haw T, Liu G, Clark A, Ammit A, 'TRISTETRAPROLIN PROTECTS MICE AGAINST CIGARETTE-SMOKE INDUCED EXPERIMENTAL COPD', RESPIROLOGY, 21 125-125 (2016) 2016 Haw TJ, Starkey MR, Nair PM, Pavlidis S, Liu G, Nguyen DH, et al., 'A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease', Mucosal Immunology, 9 859-872 (2016) [C1] 2016 Conickx G, Mestdagh P, Avila Cobos F, Verhamme FM, Maes T, Vanaudenaerde BM, et al., 'MicroRNA Profiling Reveals a Role for MicroRNA-218-5p in the Pathogenesis of Chronic Obstructive Pulmonary Disease.', Am J Respir Crit Care Med, (2016) 2016 Hsu AC, Parsons K, Moheimani F, Knight DA, Hansbro PM, Fujita T, Wark PA, 'Impaired Antiviral Stress Granule and IFN-ß Enhanceosome Formation Enhances Susceptibility to Influenza Infection in Chronic Obstructive Pulmonary Disease Epithelium.', Am J Respir Cell Mol Biol, 55 117-127 (2016) 2016 Thorburn AN, Tseng HY, Donovan C, Hansbro NG, Jarnicki AG, Foster PS, et al., 'TLR2, TLR4 AND MyD88 Mediate Allergic Airway Disease (AAD) and Streptococcus pneumoniae-Induced Suppression of AAD.', PLoS One, 11 e0156402 (2016) 2016 Tang FS, Hansbro PM, Burgess JK, Ammit AJ, Baines KJ, Oliver BG, 'A novel immunomodulatory function of neutrophils on rhinovirus-activated monocytes in vitro.', Thorax, (2016) 2016 Rahman MM, Rumzhum NN, Hansbro PM, Morris JC, Clark AR, Verrills NM, Ammit AJ, 'Activating protein phosphatase 2A (PP2A) enhances tristetraprolin (TTP) anti-inflammatory function in A549 lung epithelial cells', Cellular Signalling, 28 325-334 (2016) [C1] 2016 Rahman MM, Prabhala P, Rumzhum NN, Patel BS, Wickop T, Hansbro PM, et al., 'TLR2 ligation induces corticosteroid insensitivity in A549 lung epithelial cells: Anti-inflammatory impact of PP2A activators.', Int J Biochem Cell Biol, 78 279-287 (2016) 2016 Gang L, Hsu A, Cooley MA, Jarnicki AG, Nair PM, Haw TJ, et al., 'Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases', Journal of Clinical Investigation Insight, 1 (2016) 2016 Starkey M, Nguyen D, Kim R, Haw T, Nair P, Essilfie A, et al., 'EARLY-LIFE RESPIRATORY BACTERIAL INFECTION-INDUCED CHRONIC LUNG DISEASE IS DRIVEN BY A NOVEL TLR2/IL-13/MIR-21/PI3K SIGNALLING PATHWAY', RESPIROLOGY, 21 37-37 (2016) 2016 Kim R, Pinkerton J, Essilfie A, Robertson A, Baines K, Mayall J, et al., 'NLRP3 INFLAMMASOME- MEDIATED, IL-1 beta-DEPENDENT INFLAMMATORY RESPONSES DRIVE SEVERE, STEROID-INSENSITIVE ASTHMA', RESPIROLOGY, 21 46-46 (2016) 2016 Hansbro P, Brown A, Essilfie A, Beckett E, Thorburn A, Hansbro N, et al., 'PROGRAMMED DEATH-1 (PD-1) PREDISPOSES TO RESPIRATORY VIRAL INFECTION-INDUCED SECONDARY BACTERIAL PNEUMONIA', RESPIROLOGY, 21 58-58 (2016) 2016 Starkey M, Haw T, Pavlidis S, Nair MP, Liu G, Hanish I, et al., 'TOLL-LIKE RECEPTOR 7 PROMOTES CIGARETTE-SMOKE INDUCED EMPHYSEMA-LIKE ALVEOLAR ENLARGEMENT IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE', RESPIROLOGY, 21 79-79 (2016) 2016 Pinkerton J, Kim R, Essilfie A, Rae B, Mayall J, Ali M, et al., 'TARGETING OXIDATIVE STRESS FOR THE SUPPRESSION OF SEVERE, STEROID-INSENSITIVE ASTHMA', RESPIROLOGY, 21 105-105 (2016) 2016 Gold MJ, Hiebert PR, Park HY, Stefanowicz D, Le A, Starkey MR, et al., 'Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization.', Mucosal Immunol, 9 809-820 (2016) 2016 Hansbro P, Sunkara K, Jarnicki A, Kim R, Haw T, Wark P, et al., 'ROLE OF MIR-21 IN THE PATHOGENESIS OF EXPERIMENTAL COPD', RESPIROLOGY, 21 125-125 (2016) 2016 Moores N, Rogers DI, Rogers K, Hansbro PM, 'Reclamation of tidal flats and shorebird declines in Saemangeum and elsewhere in the Republic of Korea', Emu, 116 136-146 (2016) [C1]