研究领域

Immunology and Microbiology

Professor Paul Foster is the Director of the Priority Research Centre for Healthy Lungs; the Virus, Infection/Immunity, Vaccines and Asthma Program, Hunter Medical Research Institute and the Cooperative Research Centre (CRC) for Asthma and Airways (Newcastle node). He also currently holds the Chair of Immunology, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle. He is also a visiting Professor at Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. He serves as an Associate Editor of the American Journal of Respiratory Cell and Molecular Biology and the Journal of Pharmacology and Therapeutics, and is on the Editorial Boards of a number of leading international immunology/allergy journals. Professor Foster's research focuses on understanding the molecular and cellular basis of asthma, allergy, respiratory disorders, and chronic inflammation. His research program focuses on translational approaches directed towards the development of novel anti-inflammatory therapies. Professor Foster's research findings are published in the most highly ranked medical and biomedical science journals (e.g. Nature Immunology and Journal of Experimental Medicine). Essential Science Indicators metrics places his team on the forefront of his field internationally. Professor Foster receives numerous and ongoing invitations to speak and chair sessions and leading international conferences in immunology and respiratory medicine (e.g. American Academy of Asthma, Allergy and Immunology, Keystone, Cold Spring Harbor, International Congress on Immunology and International Eosinophil meeting). The importance of his team's work has been recognised through award of over $10.5 million in direct funding (since 2003) through Australian national competitive grants. Since 1995 Professor Foster's laboratory has focused on the biology of T cells and granulocytes, and on signaling by cytokines and chemokines pertinent to regulating allergic inflammatory responses, in particular asthma. In the last 5 years we have extended our focus to understanding the relationship between inflammation induced by infection (viruses, bacteria and microbial products), at various times through life, on the subsequent development of the T cell repertoire and on chronic inflammation in the lung. A focus on the role of microRNAs in the regulation of inflammation is also a main focus. Professor Foster's activities have been supported through grants from the NHMRC (program and project grants), Australian Research Council (Discovery and LIEF grants), Human Frontiers Science Foundation, and through the CRC for Asthma and Airways. Professor Foster actively contributes to peer review at a national and international level (e.g. NHMRC; fellowship, program and project reviews/grant panel; Wellcome Trust; and leading international journals (e.g. J. of Clin. Invest., J. of Exp. Med., and Nature).

近期论文

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2016 Munitz A, Karo-Atar D, Foster PS, 'Asthma diagnosis: MicroRNAs to the rescue', Journal of Allergy and Clinical Immunology, 137 1447-1448 (2016) 2016 Haw TJ, Starkey MR, Nair PM, Pavlidis S, Liu G, Nguyen DH, et al., 'A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease', Mucosal Immunology, 9 859-872 (2016) [C1] 2016 Nguyen TH, Maltby S, Simpson JL, Eyers F, Baines KJ, Gibson PG, et al., 'TNF-a and macrophages are critical for respiratory syncytial virus-induced exacerbations in a mouse model of allergic airways disease', Journal of Immunology, 196 3547-3558 (2016) [C1] 2016 Thorburn AN, Tseng HY, Donovan C, Hansbro NG, Jarnicki AG, Foster PS, et al., 'TLR2, TLR4 AND MyD88 Mediate Allergic Airway Disease (AAD) and Streptococcus pneumoniae-Induced Suppression of AAD.', PLoS One, 11 e0156402 (2016) 2016 Kumar RK, Herbert C, Foster PS, 'Mouse models of acute exacerbations of allergic asthma', Respirology, (2016) [C1] 2016 Xiang Y, Eyers F, Herbert C, Tay HL, Foster PS, Yang M, 'MicroRNA-487b Is a Negative Regulator of Macrophage Activation by Targeting IL-33 Production.', J Immunol, 196 3421-3428 (2016) 2016 Zhou H, Zhang J, Eyers F, Xiang Y, Herbert C, Tay HL, et al., 'Identification of the microRNA networks contributing to macrophage differentiation and function.', Oncotarget, 7 28806-28820 (2016) 2015 Herbert C, Sebesfi M, Zeng QX, Oliver BG, Foster PS, Kumar RK, 'Using multiple online databases to help identify microRNAs regulating the airway epithelial cell response to a virus-like stimulus', Respirology, 20 1206-1212 (2015) [C1] 2015 Siggs OM, Miosge LA, Daley SR, Asquith K, Foster PS, Liston A, Goodnow CC, 'Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation', Journal of Immunology, 194 2587-2595 (2015) [C1] 2015 Essilfie A, Horvat JC, Kim RY, Mayall JR, Pinkerton JW, Beckett EL, et al., 'Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma', Thorax Journal, 70 458-467 (2015) [C1] 2015 Foo SY, Zhang V, Lalwani A, Lynch JP, Zhuang A, Lam CE, et al., 'Regulatory T Cells Prevent Inducible BALT Formation by Dampening Neutrophilic Inflammation', JOURNAL OF IMMUNOLOGY, 194 4567-4576 (2015) [C1] 2015 Mateer SW, Maltby S, Marks E, Foster PS, Horvat JC, Hansbro PM, Keely S, 'Potential mechanisms regulating pulmonary pathology in inflammatory bowel disease.', J Leukoc Biol, 98 727-737 (2015) [C1] 2015 Su Y-C, Townsend D, Herrero LJ, Zaid A, Rolph MS, Gahan ME, et al., 'Dual Proinflammatory and Antiviral Properties of Pulmonary Eosinophils in Respiratory Syncytial Virus Vaccine-Enhanced Disease', JOURNAL OF VIROLOGY, 89 1564-1578 (2015) [C1] 2015 Tay HL, Kaiko GE, Plank M, Li J, Maltby S, Essilfie AT, et al., 'Correction: Antagonism of miR-328 Increases the Antimicrobial Function of Macrophages and Neutrophils and Rapid Clearance of Non-typeable Haemophilus Influenzae (NTHi) from Infected Lung.', PLoS pathogens, 11 e1004956 (2015) [O1] 2015 Li JJ, Tay HL, Maltby S, Xiang Y, Eyers F, Hatchwell L, et al., 'MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity', Journal of Allergy and Clinical Immunology, 136 462-473 (2015) [C1] 2015 Kim RY, Horvat JC, Pinkerton JW, Starkey MR, Essilfie AT, Mayall JR, et al., 'MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2', Journal of Allergy and Clinical Immunology, (2015) 2015 Hatchwell L, Collison A, Girkin J, Parsons K, Li J, Zhang J, et al., 'Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia', Thorax, (2015) [C1] 2015 Hsu ACY, Starkey MR, Hanish I, Parsons K, Haw TJ, Howland LJ, et al., 'Targeting PI3K-p110a suppresses influenza virus infection in chronic obstructive pulmonary disease', American Journal of Respiratory and Critical Care Medicine, 191 1012-1023 (2015) [C1] 2015 Plank MW, Maltby S, Tay HL, Stewart J, Eyers F, Hansbro PM, Foster PS, 'MicroRNA Expression Is Altered in an Ovalbumin-Induced Asthma Model and Targeting miR-155 with Antagomirs Reveals Cellular Specificity.', PloS one, 10 1-25 (2015) [C1] 2015 Girkin J, Hatchwell L, Foster P, Johnston SL, Bartlett N, Collison A, Mattes J, 'CCL7 and IRF-7 mediate hallmark inflammatory and IFN responses following rhinovirus 1B infection', Journal of Immunology, 194 4924-4930 (2015) [C1]