研究领域

Human Physiology

Dr Spratt leads the stroke translation laboratory within the school of Biomedical Sciences and Pharmacy, and also works as a clinical neurologist at John Hunter Hospital. He sees his role primarily as 'bridging the gap' in translational stroke research, with the aims of moving promising therapies from the laboratory into clinical use, and of answering those important clinical questions best addressed with laboratory research. His group is part of the Hunter Medical Research Institute Centre for Brain and Mental Health stroke stream and work closely with clinical, imaging and epidemiological researchers from this stream.

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

2016 Beard DJ, Logan CL, McLeod DD, Hood RJ, Pepperall D, Murtha LA, Spratt NJ, 'Ischemic penumbra as a trigger for intracranial pressure rise - A potential cause for collateral failure and infarct progression?', J Cereb Blood Flow Metab, 36 917-927 (2016) 2016 Kawano H, Bivard A, Lin L, Spratt NJ, Miteff F, Parsons MW, Levi CR, 'Relationship Between Collateral Status, Contrast Transit, and Contrast Density in Acute Ischemic Stroke', Stroke, (2016) 2016 Schleicher N, Tomkins AJ, Kampschulte M, Hyvelin JM, Botteron C, Juenemann M, et al., 'Sonothrombolysis with BR38 microbubbles improves microvascular patency in a rat model of stroke', PLoS ONE, 11 (2016) [C1] 2016 Beard DJ, Murtha LA, McLeod DD, Spratt NJ, 'Intracranial Pressure and Collateral Blood Flow', Stroke, 47 1695-1700 (2016) [C1] 2016 Bivard A, Cheng X, Lin LT, Levi C, Spratt N, Kleinig T, et al., 'Global White Matter Hypoperfusion on CT Predicts Larger Infarcts and Hemorrhagic Transformation after Acute Ischemia.', CNS Neurosci Ther, 22 238-243 (2016) 2016 Anderson CS, Robinson T, Lindley RI, Arima H, Lavados PM, Lee TH, et al., 'Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke.', N Engl J Med, 374 2313-2323 (2016) 2016 Marsden DL, Dunn A, Callister R, McElduff P, Levi CR, Spratt NJ, 'A Home- and Community-Based Physical Activity Program Can Improve the Cardiorespiratory Fitness and Walking Capacity of Stroke Survivors.', J Stroke Cerebrovasc Dis, (2016) 2016 Bhaskar S, Stanwell P, Bivard A, Spratt N, Walker R, Kitsos GH, et al., 'The influence of initial stroke severity on the likelihood of unfavourable clinical outcome and death at 90 days following acute ischemic stroke: A tertiary hospital stroke register study', Neurology India, In press (2016) 2016 Kawano H, Levi C, Inatomi Y, Pagram H, Kerr E, Bivard A, et al., 'International benchmarking for acute thrombolytic therapy implementation in Australia and Japan.', J Clin Neurosci, 29 87-91 (2016) 2016 Tomkins AJ, Hood RJ, Pepperall D, Null CL, Levi CR, Spratt NJ, 'Thrombolytic Recanalization of Carotid Arteries Is Highly Dependent on Degree of Stenosis, Despite Sonothrombolysis.', J Am Heart Assoc, 5 (2016) 2016 Murtha LA, Beard DJ, Bourke JT, Pepperall D, McLeod DD, Spratt NJ, 'Intracranial pressure elevation 24 h after ischemic stroke in aged rats is prevented by early, short hypothermia treatment', Frontiers in Aging Neuroscience, 8 (2016) 2016 Bivard A, Yassi N, Krishnamurthy V, Lin L, Levi C, Spratt NJ, et al., 'A comprehensive analysis of metabolic changes in the salvaged penumbra', Neuroradiology, 58 409-415 (2016) [C1] 2015 Murtha LA, McLeod DD, Pepperall D, McCann SK, Beard DJ, Tomkins AJ, et al., 'Intracranial pressure elevation after ischemic stroke in rats: Cerebral edema is not the only cause, and short-duration mild hypothermia is a highly effective preventive therapy', Journal of Cerebral Blood Flow and Metabolism, 35 592-600 (2015) [C1] 2015 Campbell BCV, Mitchell PJ, Kleinig TJ, Dewey HM, Churilov L, Yassi N, et al., 'Endovascular therapy for ischemic stroke with perfusion-imaging selection', New England Journal of Medicine, 372 1009-1018 (2015) [C1] 2015 White JH, Bartley E, Janssen H, Jordan LA, Spratt N, 'Exploring stroke survivor experience of participation in an enriched environment: A qualitative study', Disability and Rehabilitation, 37 593-600 (2015) [C1] 2015 Beard DJ, Mcleod DD, Logan CL, Murtha LA, Imtiaz MS, Van Helden DF, Spratt NJ, 'Intracranial pressure elevation reduces flow through collateral vessels and the penetrating arterioles they supply. A possible explanation for 'collateral failure' and infarct expansion after ischemic stroke', Journal of Cerebral Blood Flow and Metabolism, 35 861-872 (2015) [C1] 2015 Jones KA, Zouikr I, Patience M, Clarkson AN, Isgaard J, Johnson SJ, et al., 'Chronic stress exacerbates neuronal loss associated with secondary neurodegeneration and suppresses microglial-like cells following focal motor cortex ischemia in the mouse', Brain, Behavior, and Immunity, 48 57-67 (2015) [C1] 2015 Bivard A, Levi C, Krishnamurthy V, McElduff P, Miteff F, Spratt NJ, et al., 'Perfusion computed tomography to assist decision making for stroke thrombolysis', Brain, 138 1919-1931 (2015) [C1] 2015 Mcleod DD, Parsons MW, Hood R, Hiles B, Allen J, Mccann SK, et al., 'Perfusion computed tomography thresholds defining ischemic penumbra and infarct core: Studies in a rat stroke model', International Journal of Stroke, 10 553-559 (2015) [C1] 2015 Tomkins AJ, Schleicher N, Murtha L, Kaps M, Levi CR, Nedelmann M, Spratt NJ, 'Platelet rich clots are resistant to lysis by thrombolytic therapy in a rat model of embolic stroke', Experimental and Translational Stroke Medicine, 7 (2015) [C1]