个人简介

Associate Professor Walker is a senior research fellow based at the Hunter Medical Research Institute. He currently is chief investigator within the University of Newcastle's Priority Research Center in Stroke and Traumatic Brain Injury and a named research fellow for the NHMRC Center of Excellence in Stroke Recovery and Rehabilitation. Associate Professor Walker obtained his PhD from the Univeristy of Newcastle in the field of Neuroimmunology in 2006. Dr Walker then joined the systems neuroscience laboratory of Professor Trevor Day, in the School of Biomedical Sciences & Pharmacy, as an NHMRC funded postdoctoral researcher. During this time he investigated brain mechanisms that underpin individual differences in vulnerability to psychological stress. In 2007 Dr Walker was awarded an NHMRC Biomedical (Peter Doherty) Postdoctoral Fellowship. During this time his work became increasingly focused on the role of glia and neuroimmune alterations in mood disturbances. In 2009 he established the Affective Neuroscience and Neuroimmunology research group at the University of Newcastle, Australia. Over the past several years Dr Walker’s research has been focused on the role of neuroinflammation, mood disturbance and dementia. He has established himself as an emerging researcher leader in the field and is regularly invited to speak at national and international conferences, and called upon to review NHMRC grant applications and scientific manuscripts. His work is currently supported by the NHMRC and the Hunter Medical Research Institute and several philanthropic societies.

研究领域

Anatomy

The primary objective of our research group is to understand the relationship between brain injury, neuroinflammation and cognitive performance. Our research interfaces with a number of disease processes including; stroke; Alzheimers; and depression. Our research makes uses of a large variety of techniques spanning from the analysis of individual genes of interest through to the behavioural level. Our research laboratories, situated at with the School of Biomedical Sciences and Pharmacy, are ideally equipped with state of the art equipment to undertake these multi-level investigations.

近期论文

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2016 Ji P, Schachtschneider KM, Schook LB, Walker FR, Johnson RW, 'Peripheral viral infection induced microglial sensome genes and enhanced microglial cell activity in the hippocampus of neonatal piglets', Brain, Behavior, and Immunity, 54 243-251 (2016) [C1] 2016 Muccigrosso MM, Ford J, Benner B, Moussa D, Burnsides C, Fenn AM, et al., 'Cognitive deficits develop 1 month after diffuse brain injury and are exaggerated by microglia-associated reactivity to peripheral immune challenge', Brain, Behavior, and Immunity, 54 95-109 (2016) [C1] 2016 Walker FR, Pfingst K, Carnevali L, Sgoifo A, Nalivaiko E, 'In the search for integrative biomarker of resilience to psychological stress.', Neurosci Biobehav Rev, (2016) 2016 Reber SO, Siebler PH, Donner NC, Morton JT, Smith DG, Kopelman JM, et al., 'Immunization with a heat-killed preparation of the environmental bacterium Mycobacterium vaccae promotes stress resilience in mice.', Proc Natl Acad Sci U S A, 113 E3130-E3139 (2016) 2016 Hollins SL, Zavitsanou K, Walker FR, Cairns MJ, 'Alteration of transcriptional networks in the entorhinal cortex after maternal immune activation and adolescent cannabinoid exposure', Brain, Behavior, and Immunity, 56 187-196 (2016) 2016 Ong LK, Zhao Z, Kluge M, Walker FR, Nilsson M, 'Chronic stress exposure following photothrombotic stroke is associated with increased levels of Amyloid beta accumulation and altered oligomerisation at sites of thalamic secondary neurodegeneration in mice.', J Cereb Blood Flow Metab, (2016) 2016 Grace PM, Fabisiak TJ, Green-Fulgham SM, Anderson ND, Strand KA, Kwilasz AJ, et al., 'Prior voluntary wheel running attenuates neuropathic pain.', Pain, 157 2012-2023 (2016) 2016 Rohan Walker F, Yirmiya R, 'Microglia, physiology and behavior: A brief commentary', Brain, Behavior, and Immunity, 55 1-5 (2016) 2016 Norden DM, Trojanowski PJ, Walker FR, Godbout JP, 'Insensitivity of astrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain', Neurobiology of Aging, 44 22-41 (2016) 2015 Kongsui R, Johnson SJ, Graham BA, Nilsson M, Walker FR, 'A combined cumulative threshold spectra and digital reconstruction analysis reveal structural alterations of microglia within the prefrontal cortex following low-dose LPS administration', Neuroscience, 310 629-640 (2015) [C1] 2015 Patience MJ, Zouikr I, Jones K, Clarkson AN, Isgaard J, Johnson SJ, et al., 'Photothrombotic Stroke Induces Persistent Ipsilateral and Contralateral Astrogliosis in Key Cognitive Control Nuclei', NEUROCHEMICAL RESEARCH, 40 362-371 (2015) [C1] 2015 Jones KA, Zouikr I, Patience M, Clarkson AN, Isgaard J, Johnson SJ, et al., 'Chronic stress exacerbates neuronal loss associated with secondary neurodegeneration and suppresses microglial-like cells following focal motor cortex ischemia in the mouse', Brain, Behavior, and Immunity, 48 57-67 (2015) [C1] 2015 Clarkson AN, Parker K, Nilsson M, Walker FR, Gowing EK, 'Combined ampakine and BDNF treatments enhance poststroke functional recovery in aged mice via AKT-CREB signaling.', J Cereb Blood Flow Metab, 35 1272-1279 (2015) [C1] 2015 Mayhew J, Beart PM, Walker FR, 'Astrocyte and microglial control of glutamatergic signalling: a primer on understanding the disruptive role of chronic stress.', J Neuroendocrinol, 27 498-506 (2015) [C1] 2015 Iseme RA, McEvoy M, Kelly B, Agnew L, Attia J, Walker FR, et al., 'Autoantibodies are not predictive markers for the development of depressive symptoms in a population-based cohort of older adults', European Psychiatry, 30 694-700 (2015) [C1] 2014 Iseme RA, McEvoy M, Kelly B, Agnew L, Attia J, Walker FR, 'Autoantibodies and depression. Evidence for a causal link?', Neuroscience and Biobehavioral Reviews, 40 62-79 (2014) [C1] 2014 Walker FR, Jones KA, Patience MJ, Zhao Z, Nilsson M, 'Stress as necessary component of realistic recovery in animal models of experimental stroke', JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 34 208-214 (2014) [C1] 2014 Radler ME, Wright BJ, Walker FR, Hale MW, Kent S, 'Calorie restriction increases lipopolysaccharide-induced neuropeptide Y immunolabeling and reduces microglial cell area in the arcuate hypothalamic nucleus.', Neuroscience, 285 236-247 (2014) [C1] 2014 Walker FR, Beynon SB, Jones KA, Zhao Z, Kongsui R, Cairns M, Nilsson M, 'Dynamic structural remodelling of microglia in health and disease: A review of the models, the signals and the mechanisms', BRAIN BEHAVIOR AND IMMUNITY, 37 1-14 (2014) [C1] 2014 Kongsui R, Beynon SB, Johnson SJ, Mayhew J, Kuter P, Nilsson M, Walker FR, 'Chronic stress induces prolonged suppression of the P2X7 receptor within multiple regions of the hippocampus: A cumulative threshold spectra analysis', Brain, Behavior, and Immunity, 42 69-80 (2014) [C1]