个人简介

Alan Brichta is a neurobiologist with research interests in the anatomy and physiology of peripheral and central vestibular system. In particular, his studies have focused on vestibular hair cells and their associated primary afferents and has recently developed an isolated preparation of the mouse inner ear to study these unusual cellular components. This approach allows stable, high-resolution, intracellular recordings whilst the tissue undergoes near 'natural' (mechanical), rather than artificial (electrical) stimulation. Results from these studies are helping us understand the cellular mechanisms underlying normal and abnormal function associated with the peripheral vestibular apparatus. In addition, Dr. Brichta is studying vestibular nucleus neurons in the brainstem that are the major recipients of transmitted vestibular organ output. These regions are thought to be highly modifiable and may prove to be ideal targets for rational therapeutic strategies aimed at treating balance disorders. Dr. Brichta was awarded a prestigious five year Garnett Passe and Rodney Williams Memorial Foundation Senior/Principal Research Fellowship.

研究领域

Anatomy

Vestibular electrophysiological and anatomical techniques, including whole-cell patch-clamp recordings together with intracellular labelling and immunohistochemistry. Experience with in vivo and in vitro preparations. Awarded major nationally competitive grants: Continually funded NHMRC Project Grants; Garnett Passe and Rodney Williams Memorial Foundation Invited Speaker at the Royal College of Medicine, London, UK.

近期论文

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2016 Lim R, Brichta AM, 'Anatomical and physiological development of the human inner ear.', Hearing research, 338 9-21 (2016) [C1] 2016 Tadros MA, Fuglevand AJ, Brichta AM, Callister RJ, 'Intrinsic excitability differs between murine hypoglossal and spinal motoneurons.', Journal of neurophysiology, 115 2672-2680 (2016) [C1] 2016 Farrell KE, Rank MM, Keely S, Brichta AM, Graham BA, Callister RJ, 'In vivo characterization of colorectal and cutaneous inputs to lumbosacral dorsal horn neurons in the mouse spinal cord', Neuroscience, 316 13-25 (2016) [C1] 2016 Rabbitt RD, Brichta AM, Tabatabaee H, Boutros PJ, Ahn J, Della Santina CC, et al., 'Heat pulse excitability of vestibular hair cells and afferent neurons.', J Neurophysiol, 116 825-843 (2016) 2015 Tadros MA, Lim R, Hughes DI, Brichta AM, Callister RJ, 'Electrical maturation of spinal neurons in the human fetus: Comparison of ventral and dorsal horn', Journal of Neurophysiology, 114 2661-2671 (2015) [C1] 2015 Tadros MA, Farrell KE, Graham BA, Brichta AM, Callister RJ, 'Properties of sodium currents in neonatal and young adult mouse superficial dorsal horn neurons', Molecular Pain, 11 (2015) [C1] 2015 Tadros MA, Farrell KE, Graham BA, Brichta AM, Callister RJ, 'Properties of sodium currents in neonatal and young adult mouse superficial dorsal horn neurons.', Molecular pain, 11 17 (2015) 2015 Rancz EA, Moya J, Drawitsch F, Brichta AM, Canals S, Margrie TW, 'Widespread Vestibular Activation of the Rodent Cortex', JOURNAL OF NEUROSCIENCE, 35 5926-5934 (2015) [C1] 2014 Tadros MA, Farrell KE, Schofield PR, Brichta AM, Graham BA, Fuglevand AJ, Callister RJ, 'Intrinsic and synaptic homeostatic plasticity in motoneurons from mice with glycine receptor mutations', Journal of Neurophysiology, 111 1487-1498 (2014) [C1] 2014 Lim R, Drury HR, Tadros MA, Callister RJ, Brichta AM, Camp AJ, 'Preliminary Characterization of Voltage-Activated Whole-Cell Currents in Developing Human Vestibular Hair Cells and Calyx Afferent Terminals', Journal of the Association for Research in Otolaryngology, (2014) [C1] 2013 Brichta AM, 'Dizzying Inspiration', International Innovation, 52-55 (2013) 2013 Tung VWK, Di Marco S, Lim R, Brichta AM, Camp AJ, 'An Isolated Semi-intact Preparation of the Mouse Vestibular Sensory Epithelium for Electrophysiology and High-resolution Two-photon Microscopy', Journal of Visualized Experiments, (2013) [C1] 2013 Hübner PP, Lim R, Brichta AM, Migliaccio AA, 'Glycine Receptor Deficiency and Its Effect on the Horizontal Vestibulo-ocular Reflex: a Study on the SPD1J Mouse', Journal of the Association for Research in Otolaryngology, 14 249-259 (2013) [C1] 2012 Tadros MA, Harris B, Anderson WB, Brichta AM, Graham BA, Callister RJ, 'Are all spinal segments equal: Intrinsic membrane properties of superficial dorsal horn neurons in the developing and mature mouse spinal cord', Journal of Physiology, 590 2409-2425 (2012) [C1] 2012 De Oliveira R, Gravina FS, Lim R, Brichta AM, Callister RJ, Van Helden DF, 'Heterogeneous responses to antioxidants in noradrenergic neurons of the Locus coeruleus indicate differing susceptibility to free radical content', Oxidative Medicine and Cellular Longevity, 2012 820285 (2012) [C1] 2011 De Oliveira R, Gravina FS, Lim R, Brichta AM, Callister RJ, Van Helden DF, 'Developmental changes in pacemaker currents in mouse locus coeruleus neurons', Brain Research, 1425 27-36 (2011) [C1] 2011 Lim R, McPherson AE, Donne SW, Callister RJ, Brichta AM, 'Potassium accumulation between type I hair cells and calyx terminals in mouse crista', Experimental Brain Research, 210 607-621 (2011) [C1] 2011 Flynn JR, Brichta AM, Galea MP, Callister RJ, Graham BA, 'A horizontal slice preparation for examining the functional connectivity of dorsal column fibres in mouse spinal cord', Journal of Neuroscience Methods, 200 113-120 (2011) [C1] 2010 Jobling P, Graham BA, Brichta AM, Callister RJ, 'Cervix stimulation evokes predominantly subthreshold synaptic responses in mouse thoracolumbar and lumbosacral superficial dorsal horn neurons', Journal of Sexual Medicine, 7 2068-2076 (2010) [C1] 2010 Lim R, Camp AJ, Walsh MA, Callister RJ, Brichta AM, 'In vitro whole-cell conductances recorded from developing human cristae.', J Vestib Res, 285-286 (2010)