个人简介
Dr Galettis currently holds the position of Head of the Clinical Pharmacology Laboratory and Senior Lecturer at the University of Newcastle. Previously he has held the positions of: Senior Medical Scientist at SA pathology (2010-2015) where he was responsible for the development and implementation of new assays for the Division of Chemical Pathology; Senior Scientific Officer at the Cancer Care Centre, St George Hospital (2000-2010) where he led the Cancer Pharmacology and Therapeutics group; and Research Fellow in the Department of Pharmacology and Clinical Pharmacology, University of Auckland (1996-2000). Dr Galettis's research interests are entirely within the field of clinical pharmacology and toxicology, specializing in assay development for use in drug monitoring for the last 25 years, focussing on anticancer agents and drugs of abuse .
近期论文
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2016 Goulooze SC, Galettis P, Boddy AV, Martin JH, 'Monte Carlo simulations of the clinical benefits from therapeutic drug monitoring of sunitinib in patients with gastrointestinal stromal tumours', CANCER CHEMOTHERAPY AND PHARMACOLOGY, 78 209-216 (2016)
2013 Ehteda A, Galettis P, Pillai K, Morris DL, 'Combination of Albendazole and 2-Methoxyestradiol significantly improves the survival of HCT-116 tumor-bearing nude mice', BMC CANCER, 13 (2013)
2012 Ehteda A, Galettis P, Chu SWL, Pillaii K, Morris DL, 'Complexation of Albendazole with Hydroxypropyl-beta-Cyclodextrin Significantly Improves its Pharmacokinetic Profile, Cell Cytotoxicity and Antitumor Efficacy in Nude Mice', ANTICANCER RESEARCH, 32 3659-3666 (2012)
2011 Mitchell PL, Broad A, Rosenthal MA, Galettis P, Abraham R, Burns I, et al., 'Randomized phase 2 sequencing and pharmacokinetic study of gemcitabine and oxaliplatin in advanced non-small cell lung cancer', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 7 376-384 (2011)
2011 Luk PP, Galettis P, Links M, 'ERK phosphorylation predicts synergism between gemcitabine and the epidermal growth factor receptor inhibitor AG1478', LUNG CANCER, 73 274-282 (2011)
2011 Manners S, Galettis P, Souza PD, 'Conditions causing gemcitabine crystallization', Journal of Oncology Pharmacy Practice, 17 395-399 (2011)
2011 Metharom E, Galettis P, Manners S, Jelinek M, Liauw W, de Souza PL, et al., 'The pharmacological advantage of prolonged dose rate gemcitabine is restricted to patients with variant alleles of cytidine deaminase c.79A > C', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 7 65-74 (2011)
2010 Pourgholami MH, Cai ZY, Chu SWL, Galettis P, Morris DL, 'The Influence of Ovarian Cancer Induced Peritoneal Carcinomatosis on the Pharmacokinetics of Albendazole in Nude Mice', ANTICANCER RESEARCH, 30 423-428 (2010)
2010 Metharom E, Galettis P, Manners S, Links M, 'Modulation of Gemcitabine Accumulation by DNA-Damaging Agents: Mechanisms and Specificity in an In Vitro Model', ANTICANCER RESEARCH, 30 3669-3673 (2010)
2010 Scott KF, Sajinovic M, Hein J, Nixdorf S, Galettis P, Liauw W, et al., 'Emerging roles for phospholipase A(2) enzymes in cancer', BIOCHIMIE, 92 601-610 (2010)
2010 Pourgholami MH, Szwajcer M, Chin M, Liauw W, Seef J, Galettis P, et al., 'Phase I clinical trial to determine maximum tolerated dose of oral albendazole in patients with advanced cancer', CANCER CHEMOTHERAPY AND PHARMACOLOGY, 65 597-605 (2010)
2009 McPherson RAC, Galettis PT, de Souza PL, 'Enhancement of the activity of phenoxodiol by cisplatin in prostate cancer cells', BRITISH JOURNAL OF CANCER, 100 649-655 (2009)
2008 Liu JJ, Galettis P, Farr A, Maharaj L, Samarasinha H, McGechan AC, et al., 'In vitro antitumour and hepatotoxicity profiles of Au(I) and Ag(I) bidentate pyridyl phosphine complexes and relationships to cellular uptake', JOURNAL OF INORGANIC BIOCHEMISTRY, 102 303-310 (2008)
2008 Jiang X, Galettis P, Links M, Mitchell PL, McLachlan AJ, 'Population pharmacokinetics of gemcitabine and its metabolite in patients with cancer: effect of oxaliplatin and infusion rate', BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 65 326-333 (2008)
2007 Cai Z-Y, Galettis P, Lu Y, Morris DL, Pourgholami MH, 'Pharmacokinetics of albendazole in New Zealand white rabbits: Oral versus intraperitoneal administration', ANTICANCER RESEARCH, 27 417-422 (2007)
2007 Grimison P, Galettis P, Manners S, Jelinek M, Metharom E, de Souza PL, et al., 'Randomized crossover study evaluating the effect of gemcitabine infusion dose rate: Evidence of auto-induction of gemcitabine accumulation', JOURNAL OF CLINICAL ONCOLOGY, 25 5704-5709 (2007)
2006 Gan HK, Mitchell PL, Galettis P, Davis ID, Cebon J, de Souza P, Links M, 'A phase 1 and pharmacokinetic study of gemcitabine and oxaliplatin in patients with solid tumors', CANCER CHEMOTHERAPY AND PHARMACOLOGY, 58 157-164 (2006)
2000 Screnci D, McKeage MJ, Galettis P, Hambley TW, Palmer BD, Baguley BC, 'Relationships between hydrophobicity, reactivity, accumulation and peripheral nerve toxicity of a series of platinum drugs', BRITISH JOURNAL OF CANCER, 82 966-972 (2000)
2000 McKeage MJ, Berners-Price SJ, Galettis P, Bowen RJ, Brouwer W, Ding L, et al., 'Role of lipophilicity in determining cellular uptake and antitumour activity of gold phosphine complexes', CANCER CHEMOTHERAPY AND PHARMACOLOGY, 46 343-350 (2000)
1999 Berners-Price SJ, Bowen RJ, Galettis P, Healy PC, McKeage MJ, 'Structural and solution chemistry of gold(I) and silver(I) complexes of bidentate pyridyl phosphines: selective antitumour agents', COORDINATION CHEMISTRY REVIEWS, 185-6 823-836 (1999)
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