个人简介

I arrived at the University of Newcastle in 1998 to take up a part time teaching appointment and was promoted to Lecturer as of 1 Jan 2005. Since arriving at the University, as well as developing a teaching profile based on 200+ contact hours per annum, I have established myself as a researcher in the area of early male germ cell differentiation. I am now producing consistent output: I have coauthored 1 book chapter and 9 manuscripts in the last 4 years as well as 28 conference presentations. I have presented my work nationally and internationally (American Society of Andrology, USA, Phoenix USA 2003, UK Environmental Mutagenesis Society & 3rd International Congress on Male Mediated Developmental Toxicity, Bradford UK, 2005). As an indication of the continual rise in my profile I recently chaired a session at a national meeting (Australian Society of Reproductive Biology). I currently serve on the Program Organising Committee for the 2007 annual meeting of the Society. I regularly review manuscripts for journals in both the Reproductive and Developmental biology fields. Student outcomes: I have successfully cosupervised Honours students with 7/10 awarded First Class since 1999. I have successfully supervised, as sole supervisor, one PhD student to completion (R. Baleato, PhD awarded 2005) with a publication in a high impact journal. Dr Baleatos thesis was unanimously praised by the assessors as being of a high standard. I have cosupervised two PhD students to completion M Wade (PhD awarded 2004) and J Holt (PhD awarded 2006). Both students have generated significant publications from their PhD projects. I currently cosupervise one student who is generating a manuscript for submission. I have been interviewed by various media (Fairfax 2004, 2006, NBN television 2005, The Medical Journal of Australia 2005). I have briefed government authorities on the neglected role of the male in the health of the offspring: Presentation to the Dept of Health and Aging, Office of Chemical Safety, Science Forum: Endocrine Disruptors: A Human Health Problem? Canberra, 2005.

研究领域

Biological Sciences

My experience is in gene expression and regulation, initially in breast cancer (Clarke et. al., 1990, 1991, Roman et. al., 1992, 1993). That work was focused on the role of retinoids in regulating gene expression in breast cancer and includes the initial description of the relationship between retinoid receptors and steroid hormone receptor status (Roman et. al., 1992). Retinoids are now part of the clinical arsenal employed in breast cancer treatment. On the basis of my interest in retinoids, I became interested in retinoids and stem cell biology (Lane et. al, 1999). That work involved metabolic profiling of embryonic stem cells. After a brief hiatus in the field of immunology, I arrived in Newcastle. My experience in the regulation of gene expression lead me to establish a number of techniques if use in Reproductive Science such as subtractive hybridisation and microarray analysis. Using these approaches and a number of other techniques we have cloned and characterised a number of genes (e.g. Curry et. al., 2004, Holt et. al., 2006). In summary I have moved across fields, in the majority of cases employing new techniques to generate outcomes. I have now established a group focused on early germ cell differentiation. We have isolated spermatogonia and characterised gene expression in these cells. In particular we have sought to explain the arrested spermatogenesis found with vitamin A deficiency (Baleato et. al., 2005). Along with Prof R. John Aitken and Dr Eileen McLaughlin, I represent the Newcastle hub of the ARC Centre of Excellence in Biotechnology and Development. Dr McLaughlin and I supervise a programme within the Centre that has the immortalisation of spermatogonial stem cells as its goal. I also cosupervise a PhD project with Prof David Jans (Monash) addressing the role DNA packaging in DNA damage. Prof Aitken and I collaborate on the role of environmental exposure in generating DNA damage in the male germ line (Aitken et. al., 2006, 2007).

近期论文

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2016 Stanger SJ, Law EA, Jamsai D, O'Bryan MK, Nixon B, McLaughlin EA, et al., 'A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation.', FASEB J, 30 2777-2791 (2016) [C1] 2016 Katen AL, Stanger SJ, Anderson AL, Nixon B, Roman SD, 'Chronic acrylamide exposure in male mice induces DNA damage to spermatozoa; Potential for amelioration by resveratrol.', Reprod Toxicol, 63 1-12 (2016) 2015 Katen AL, Roman SD, 'The genetic consequences of paternal acrylamide exposure and potential for amelioration', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 777 91-100 (2015) [C1] 2015 Reid AT, Anderson AL, Roman SD, McLaughlin EA, McCluskey A, Robinson PJ, et al., 'Glycogen synthase kinase 3 regulates acrosomal exocytosis in mouse spermatozoa via dynamin phosphorylation', FASEB JOURNAL, 29 2872-2882 (2015) [C1] 2014 Nixon BJ, Katen AL, Stanger SJ, Schjenken JE, Nixon B, Roman SD, 'Mouse spermatocytes express CYP2E1 and respond to acrylamide exposure', PLoS ONE, 9 (2014) [C1] 2013 McIver SC, Loveland KL, Roman SD, Nixon B, Kitazawa R, McLaughlin EA, 'The chemokine CXCL12 and its receptor CXCR4 are implicated in human seminoma metastasis', ANDROLOGY, 1 517-529 (2013) [C1] 2012 Reid AT, Lord T, Stanger SJ, Roman SD, McCluskey A, Robinson PJ, et al., 'Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa', Journal of Biological Chemistry, 287 37659-37672 (2012) [C1] 2012 Sutherland JM, Keightley RA, Nixon B, Roman SD, Robker RL, Russell DL, McLaughlin EA, 'Suppressor of cytokine signaling 4 (SOCS4): Moderator of ovarian primordial follicle activation', Journal of Cellular Physiology, 227 1188-1198 (2012) [C1] 2012 Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Jumping the gun: Smoking constituent BaP causes premature primordial follicle activation and impairs oocyte fusibility through oxidative stress', Toxicology and Applied Pharmacology, 260 70-80 (2012) [C1] 2012 Sobinoff AP, Nixon B, Roman SD, McLaughlin EA, 'Staying alive: PI3K pathway promotes primordial follicle activation and survival in response to 3MC-induced ovotoxicity', Toxicological Sciences, 128 258-271 (2012) [C1] 2012 Nixon BJ, Stanger SJ, Nixon B, Roman SD, 'Chronic exposure to acrylamide induces DNA damage in male germ cells of mice', Toxicological Sciences, 129 135-145 (2012) [C1] 2012 McIver SC, Roman SD, Nixon B, McLaughlin EA, 'miRNA and mammalian male germ cells', Human Reproduction Update, 18 44-59 (2012) [C1] 2012 McIver SC, Stanger SJ, Santarelli DMF, Roman SD, Nixon B, McLaughlin EA, 'A unique combination of male germ cell mirnas coordinates gonocyte differentiation', PLoS One, 7 1-14 (2012) [C1] 2011 Sobinoff AP, Mahony M, Nixon B, Roman SD, McLaughlin EA, 'Understanding the villain: DMBA-induced preantral ovotoxicity involves selective follicular destruction and primordial follicle activation through PI3K/Akt and mTOR signaling', Toxicological Sciences, 123 563-575 (2011) [C1] 2010 Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Adding insult to injury: Effects of xenobiotic-induced preantral ovotoxicity on ovarian development and oocyte fusibility', Toxicological Sciences, 118 653-666 (2010) [C1] 2008 Aitken RJ, Roman SD, 'Antioxidant systems and oxidative stress in the testes (Reprinted from Molecular Mechanisms in Spermatogenesis, 2007)', OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 1 15-24 (2008) [C3] 2006 Holt JE, Roman SD, Aitken RJ, McLaughlin EA, 'Identification and characterization of a novel Mt-retrotransposon highly represented in the female mouse germline', Genomics, 87 490-499 (2006) [C1] 2006 Aitken RJ, Skakkebaek NE, Roman SD, 'Male reproductive health and the environment (Editorial)', Medical Journal of Australia, 185 414-415 (2006) [C3] 2006 Holt JE, Jackson A, Roman SD, Aitken RJ, Koopman PA, McLaughlin EA, 'CXCR4/SDF1 interaction inhibits the primordial to primary follicle transition in the neonatal mouse ovary', Developmental Biology, 293 449-460 (2006) [C1] 2006 Prabhu SM, Meistrich ML, McLaughlin EA, Roman SD, Warne S, Mendis S, et al., 'Expression of c-Kit receptor mRNA and protein in the developing, adult and irradiated rodent testis', Reproduction, 131 489-499 (2006) [C1]