个人简介

I obtained my BSc (Hons) and PhD in organic chemistry from the University of Strathclyde in Scotland. At the completion of my studies I took up a postdoctoral position at the University of Queensland in the area of reactive intermediates chemistry (spectroscopy at -261 ºC). After a 2 year stay, I changed research direction working alongside Professor Ron Quinn at Griffith University as a synthetic medicinal chemist. It was here I developed an interest in medicinal chemistry and teaching. In December 1995 I was fortunate to secured a position as lecturer in organic and medicinal chemistry at the University of Newcastle. My team (the ones who do all the work) is responsible for >175 research publications and we have secured ~$25M in research funding since my arrival in Newcastle.

研究领域

Chemistry

Medicinal Chemistry; * Inhibition of Protein Phosphatases as a therapeutic Strategy * Inhibition of Dynamin GTPase * Prevention of Pre-term delivery in Humans: Agonists & antagonists of Corticotrophin Releasing Hormone (CRH) Green Chemistry; Overarching Interest is in the application of organic chemistry strategies in the development of new therapeutic agents (Organic and Medicinal Chemistry). Additionally, given environmental and public concerns relating to Chemistry we are driven by a desire to develop Green Chemistry approaches in our organic and medicinal chemistry targets. Emphasis is placed on solvent free reactions, atom efficiency, replacement of volatile organic solvents with environmentally friendly equivalents (ionic liquids), and evaluation of the most efficient synthetic routes to the desired end-points. My group's primary interests are in developing novel compounds with the ability to inhibit a number of signal transduction pathways. The potential outcomes of our research include (but are not limited to) the development of new synthetic methodologies; the development of new drugs & the development of new tools for dissecting signal transduction pathways.

近期论文

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2016 Zaleta-Pinet D, McCluskey A, Hall S, Brophy J, Ashhurst-Smith C, Sakoff J, Van Altena I, 'The Use of the Toxic Plant Myoporum montanum in a Traditional Australian Aboriginal Medicine', Australian Journal of Chemistry, 69 161-168 (2016) 2016 Abraham RJ, Stevens AJ, Young KA, Russell C, Qvist A, Khazandi M, et al., 'Robenidine Analogues as Gram-Positive Antibacterial Agents.', J Med Chem, 59 2126-2138 (2016) 2016 Trinh TN, McCluskey A, 'A multicomponent access to 1,3-thiazine-6-phenylimino-5-carboxylates', TETRAHEDRON LETTERS, 57 3256-3259 (2016) 2016 Trinh TN, McLaughlin EA, Abdel-Hamid MK, Gordon CP, Bernstein IR, Pye V, et al., 'Quinolone-1-(2H)-ones as hedgehog signalling pathway inhibitors.', Org Biomol Chem, 14 6304-6315 (2016) 2015 Cossar PJ, Hizartzidis L, Simone M, McCluskey A, Gordon CP, 'The expanding utility of continuous flow hydrogenation', Organic and Biomolecular Chemistry, 26 7119-7130 (2015) [C1] 2015 Lees JG, Gorgani NN, Ammit AJ, McCluskey A, Robinson PJ, O'Neill GM, 'Role of dynamin in elongated cell migration in a 3D matrix', Biochimica et Biophysica Acta - Molecular Cell Research, 1853 611-618 (2015) [C1] 2015 Zayas HA, McCluskey A, Bowyer MC, Holdsworth CI, 'Potentiometric determination of acid dissociation constants of novel biaryl monomers', Analytical Methods, 7 8206-8211 (2015) [C1] 2015 Daniel JA, Chau N, Abdel-Hamid MK, Hu L, von Kleist L, Whiting A, et al., 'Phenothiazine-derived antipsychotic drugs inhibit dynamin and clathrin-mediated endocytosis', Traffic, (2015) [C1] 2015 Rixson JE, Abraham JR, Egoshi Y, Skelton BW, Young K, Gilbert J, et al., 'The synthesis and biological activity of novel anthracenone-pyranones and anthracenone-furans', Bioorganic and Medicinal Chemistry, 23 3552-3565 (2015) [C1] 2015 Abdel-Hamid MK, Macgregor KA, Odell LR, Chau N, Mariana A, Whiting A, et al., '1,8-Naphthalimide derivatives: New leads against dynamin i GTPase activity', Organic and Biomolecular Chemistry, 13 8016-8028 (2015) [C1] 2015 Reid AT, Anderson AL, Roman SD, McLaughlin EA, McCluskey A, Robinson PJ, et al., 'Glycogen synthase kinase 3 regulates acrosomal exocytosis in mouse spermatozoa via dynamin phosphorylation', FASEB JOURNAL, 29 2872-2882 (2015) [C1] 2015 Russell C, Lin AJS, Hains P, Simone MI, Robinson PJ, Mccluskey A, 'An integrated flow and microwave approach to a broad spectrum protein kinase inhibitor', RSC Advances, 5 93433-93437 (2015) [C1] 2015 Jackson J, Papadopulos A, Meunier FA, McCluskey A, Robinson PJ, Keating DJ, 'Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release.', Mol Psychiatry, 20 810-819 (2015) [C1] 2015 Caì Y, Postnikova EN, Bernbaum JG, Yú S, Mazur S, Deiuliis NM, et al., 'Simian hemorrhagic fever virus cell entry is dependent on CD163 and uses a clathrin-mediated endocytosis-like pathway', Journal of Virology, 89 844-856 (2015) [C1] 2014 Abdel-Hamid MK, McCluskey A, 'In Silico docking, molecular dynamics and binding energy insights into the bolinaquinone-clathrin terminal domain binding site', Molecules, 19 6609-6622 (2014) [C1] 2014 Hizartzidis L, Tarleton M, Gordon CP, McCluskey A, 'Chemoselective flow hydrogenation approaches to isoindole-7-carboxylic acids and 7-oxa-bicyclio[2.2.1]heptanes', RSC Advances, 4 9709-9722 (2014) [C1] 2014 Al Otaibi A, Gordon CP, Gilbert J, Sakoff JA, McCluskey A, 'The influence of ionic liquids on the Knoevenagel condensation of 1H-pyrrole-2-carbaldehyde with phenyl acetonitriles-cytotoxic 3-substituted-(1H-pyrrol-2-yl)acrylonitriles', RSC Advances, 4 19806-19813 (2014) [C1] 2014 Hizartzidis L, Cossar PJ, Robertson MJ, Simone MI, Young KA, McCluskey A, Gordon CP, 'Expanding the utility of flow hydrogenation - A robust protocol restricting hydrodehalogenation', RSC Advances, 4 56743-56748 (2014) [C1] 2014 Zaleta-Pinet DA, Holland IP, Muñoz-Ochoa M, Murillo-Alvarez JI, Sakoff JA, van Altena IA, McCluskey A, 'Cytotoxic compounds from Laurencia pacifica.', Org Med Chem Lett, 4 8 (2014) 2014 Stahlschmidt W, Robertson MJ, Robinson PJ, McCluskey A, Haucke V, 'Clathrin Terminal Domain- Ligand Interactions Regulate Sorting of Mannose 6-Phosphate Receptors Mediated by AP-1 and GGA Adaptors*', JOURNAL OF BIOLOGICAL CHEMISTRY, 289 4906-4918 (2014) [C1]