Paton, Rob - University of Oxford - Department of Chemistry

个人简介

After graduating top of his year in Natural Sciences at the University of Cambridge, Rob obtained his PhD in 2008 with Jonathan Goodman in Cambridge working on the automated parameterization of molecular mechanics methods to study stereoselective C-C bond formation. In 2008 he took up an independent Junior Research Fellowship at St Catharine's College, Cambridge, and courtesy of an HPC-Europa award in 2009 spent time in the group of Feliu Maseras at ICIQ, Spain. As recipient of the UK's' Fulbright-AstraZeneca Fellowship and a Science Fellowship from the Royal Commission of the Exhibition of 1851, Rob conducted postdoctoral research with K. N. Houk at the University of California, Los Angeles from 2009-2010. In 2010 Rob was appointed to a University Lectureship and Tutorial Fellowship at Oxford, where he remains as an Associate Professor in the Department of Chemistry. In 2014 Rob was awarded the 2014 MGMS Silver Jubilee Prize, and is the 2015 recipient of the RSC Harrison-Meldola Memorial Prize and an ACS OpenEye Outstanding Junior Faculty Award.

研究领域

The Paton Group: Computational Organic Chemistry The group's research interests focus on solving problems in organic and bio-organic chemistry using computational methods. Predictions and designs of new reactions, reagents, and catalysts are tested through our close collaborations with experimentalists. Please visit our Research Group Website for further information.

近期论文

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Experimental and Theoretical Study of Oxidative Stability of Alkylated Furans Used as Gasoline Blend Components Christensen, E.; Fioroni, G. M.; Kim, S.; Fouts, L.; Gjersing, E.; Paton, R. S.; McCormick, R. Fuel 2018, 212, 576–585. Total synthesis of (−)-himalensine A Shi, H.; Michaelides, I.; Darses, B.; Jakubec, P.; Nguyen, Q. N.; Paton*, R. S.; Dixon, D. J. J. Am. Chem. Soc. 2017, in press. Direct sulfonylation of anilines mediated by visible light Johnson, T. C.; Elbert, B. L.; Farley, A. J. M.; Gorman, T. W.; Genicot, C.; Lallemand, B.; Pasau, P.; Flasz, J.; Castro, J. L.; MacCoss, M.; Dixon, D. J.; Paton*, R. S.; Schofield, C. J.; Smith, M. D.; Willis, M. C. Chem. Sci. 2017, in press. Construction of 6,10-syn- and anti-2,5-Dioxabicyclo[2.2.1]heptane Skeletons via Oxonium Ion Formation-Fragmentation: Prediction of Structure of (E)-Ocellenyne by NMR Calculation Jeong, D.; Sohn, T.-I.; Kim, J. Y.; Kim, G.; Kim, D.; Paton, R. S. Org. Lett. 2017, article ASAP. Asymmetric Induction in C-Alkylation of Tropane-Derived Enamines: Congruence Between Computation and Experiment Li, Y.; Jackson, K. E.; Charlton, A.; Le Neve-Foster, B.; Khurshid, A.; Rudy, H.-K. A.; Thompson, A. L.; Paton*, R. S.; Hodgson, D. M. J. Org. Chem. 2017, 82, 10479-10488. Enantioselective conjugate addition catalyzed by a copper-phosphoramidite complex: Computational and experimental exploration of asymmetric induction Ardkhean, R.; Roth, P. M. C.; Maksymowicz, R. M.; Curran, A.; Peng, Q.; Paton*, R. S.; Fletcher, S. P. ACS Catal. 2017, 7, 6729-6737. A C-H Cyanation of 6-Ring N-Containing Heteroaromatics Elbert, B. L.; Farley, A. J. M.; Gorman, T. M.; Johnson, T. C.; Genicot, G.; Lallemand, B.; Pasau, P.; Flasz, J.; Castro, J. L.; MacCoss, M.; Paton*, R. S.; Schofield, C. J.; Smith, M. D.; Willis, M .C.; Dixon, D. J. Chem. Eur. J. 2017, 23, 14733-14737. AMP binding stabilizes the KTN domain of the Shewanella denitrificans Kef potassium efflux system Pliotas, C.; Grayer, S. C.; Ekkerman, S.; Chan, A. K. N.; Healy, J.; Marius, P.; Bartlett, W.; Khan, A.; Cortopassi, W. A.; Chandler, S. A.; Rasmussen, T.; Benesch, J. L. P.; Paton, R. S.; Claridge, T. D. W.; Miller, S.; Booth, I. R.; Naismith, J. H.; Conway, S. J. Biochemistry 2017, 56, 4219-4234. Mechanistic insight into palladium-catalyzed cycloisomerization: A combined experimental and theoretical study Mekareeya, A.; Walker, P. R.; Couce-Rios, A.; Campbell, C. D.; Steven, A.; Paton*, R. S.; Anderson, E. A. J. Am. Chem. Soc. 2017, 139, 10104–10114. Visible light photocatalysis of 6-pi heterocyclization Münster, N.; Parker, N. A.; van Dijk, L.; Paton*, R. S.; Smith, M. D. Angew. Chem. Int. Ed. 2017, 56, 9468-9472. Molecular Recognition in Asymmetric Counteranion Catalysis: Understanding Chiral Phosphate- Mediated Desymmetrization Duarte, F.; Paton*, R. S. J. Am. Chem. Soc. 2017, 139, 8886-8896. Structural and Stereoelectronic Insights into Oxygenase Catalyzed Formation of Ethylene from 2-Oxoglutarate Zhang, Z.; Smart, T. J.; Choi, H.; Hardy, F.; Lohans, C. T.; Abboud, M. I.; Richardson, M. S. W.; Paton, R. S.; McDonough, M. A.; Schofield, C. J. Proc. Nat. Acad. Sci. 2017, 114, 4667-4672. Enantioselective Silver and Amine Co-catalyzed Desymmetrizing Cycloisomerization of Alkyne-linked Cyclohexanones Manzano, R.; Datta, S.; Paton*, R. S.; Dixon, D. J. Angew. Chem. Int. Ed. 2017, 56, 5834–5838. Phosphazene Catalyzed Addition to Electron-Deficient Alkynes: The Importance of Nonlinear Allenyl Intermediates upon Stereoselectivity Simón, L..; Paton*, R. S. J. Org. Chem. 2017, 82, 3855–3863. Dual Gold‐Catalyzed Three‐Component Reaction: Efficient Synthesis of Indene‐Fused Esters, Acids, and Lactones through Gold Vinylidene Intermediates Yu, C.; Ma, X.; Chen, B.; Tang, B.; Paton*, R. S.; Zhang, G. Eur. J. Org. Chem. 2017, 11, 1561–1565. Divergent Photocyclization/1,4-Sigmatropic Rearrangements for the Synthesis of Sesquiterpenoid Derivatives Gorobets, E.; Wong, N. E.; Paton, R. S.; Derksen, D. J. Org. Lett. 2017, 19, 484–487. Detailed Mechanistic Studies on Palladium-Catalyzed Selective C−H Olefination with Aliphatic Alkenes - A Significant Influence of Proton Shuttling Deb, A.; Hazra, A.; Peng, Q.; Paton*, R. S.; Maiti, D. J. Am. Chem. Soc. 2017, 139, 763–775. Correlating Reactivity and Selectivity to Cyclopentadienyl Ligand Properties in Rh(III)-Catalyzed C−H Activation Reactions — An Experimental and Computational Study Piou, T.; Romanov-Michailidis, F.; Romanova-Michaelides, M.; Jackson, K. E.; Semakul, N.; Taggart, T. D.; Newell, B. S.; Rithner, C. D.; Paton*, R. S.; Rovis, T. J. Am. Chem. Soc. 2017, 39, 1296–1310. Heptamethyl Indenyl (Ind*) Enables Diastereoselective Benzamidation of Cyclopropenes via Rh(III)-Catalyzed C-H Activation Semakul, N.; Jackson, K. E.; Paton*, R. S.; Rovis, T. Chem. Sci. 2017, 8, 1015–1020.