个人简介

Dr. Anderson completed doctoral studies at the University of New England, New South Wales in 2001. His doctoral research was on the accumulation of a trace metal, cobalt, as well as vitamin B12 synthesis in the obligate anaerobic bacterium, Selenomonas ruminantium. In 2001, he took up a postdoctoral research position at the University of Utah with John Roth's genetics lab. About a year later, the entire lab moved to the University of California, Davis. In John Roth's lab, Dr. Anderson learned to use bacterial genetic techniques to determine the final steps involved in the synthesis of vitamin B12 cofactors in Salmonella. As it turned out, Salmonella was making pseudovitamin B12 rather than vitamin B12. With some help from Prof. Bernhard Kräutler at the University of Innsbruk, who gifted a tiny amount of otherwise unobtainable pure pseudovitamin B12, it was possible to show that this bacterial cofactor was biologically relevant in the ethanoloamine ammonia lyase and methionine synthase reactions as well as being able to characterise the compounds made by thirty or so Salmonella B12 point mutants. A spin-off from this research was that it allowed the synthesis of carbon-14 vitamin B12 and, therefore, the use of carbon dating techniques that are sensitive enough to follow the vitamin's complicated uptake in human. In October 2006, Dr. Anderson moved from Davis, California to Monash University, Clayton and worked on the red blood cell stage of the malaria parasite; searching for potential vaccine candidates. In July 2009, he took up a faculty position with the School of Biomedical Sciences at Charles Sturt University, Orange, New South Wales.

研究领域

Microbiology

Research Interests: Vitamin B12: synthesis, use and applications Antibiotic discovery using microbial genetics Bacterial genetics Gut-brain-mood: the idea that the bacteria in our gut impact our mood

近期论文

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Kudinha T, Johnson JR, Andrew SD, Kong F, Anderson P, Gilbert GL. Escherichia coli Sequence Type 131 (ST131) as a Prominent Cause of Antibiotic Resistance among Urinary Escherichia coli Isolates from Reproductive-age Women. Journal of clinical microbiology. 2013:JCM. 01315-13. Kudinha T, Johnson JR, Andrew SD, Kong F, Anderson P, Gilbert GL. Genotypic and phenotypic characterization of Escherichia coli isolates from children with urinary tract infection and from healthy carriers. The Pediatric infectious disease journal. 2013;32(5):543-8. Kudinha T, Johnson J, Andrew S, Kong F, Anderson P, Gilbert G. Distribution of phylogenetic groups, sequence type ST131, and virulence‐associated traits among Escherichia coli isolates from men with pyelonephritis or cystitis and healthy controls. Clinical Microbiology and Infection. 2013;19(4):E173-E80. Kudinha T, Kong F, Johnson JR, Andrew SD, Anderson P, Gilbert GL. Multiplex PCR-based reverse line blot assay for simultaneous detection of 22 virulence genes in uropathogenic Escherichia coli. Applied and environmental microbiology. 2012;78(4):1198-202. Anderson PJ, Dueker S, Miller J, Green R, Roth J, Carkeet C, et al. Assay for vitamin B12 absorption and method of making labelled vitamin B12. US Patent 20,120,264,174; 2012. Anderson, P. J., Lango, J., Carkeet, C., Britten, A., Kräutler, B., Hammock, B. D., & Roth, J. R. (2008). One pathway can incorporate either adenine or dimethylbenzimidazole as an α-axial ligand of B12 cofactors in Salmonella enterica. Journal of bacteriology, 190(4), 1160-1171. Miller JW, Dueker SR, Carkeet C, Anderson P, Buchholz BA, Green R. Measurement of vitamin B12 absorption in a human subject using 14C-B12. The FASEB Journal. 2006;20:A858. Carkeet C, Dueker SR, Lango J, Buchholz BA, Miller JW, Green R, Bruce D. Hammock, John R. Roth and Peter J. Anderson. Human vitamin B12 absorption measurement by accelerator mass spectrometry using specifically labeled 14C-cobalamin. Proceedings of the National Academy of Sciences. 2006;103(15):5694-9. Campbell GR, Taga ME, Mistry K, Lloret J, Anderson PJ, Roth JR, et al. Sinorhizobium meliloti bluB is necessary for production of 5, 6-dimethylbenzimidazole, the lower ligand of B12. Proceedings of the National Academy of Sciences of the United States of America. 2006;103(12):4634-9. Anderson PJ, Cole LJ, McKay DB, Entsch B. A flavoprotein encoded in Selenomonas ruminantium is characterized after expression in Escherichia coli. Protein Expr Purif. 2002;24(3):429-38. Anderson PJ, Entsch B, McKay DB. A gene, cobA+hemD, from Selenomonas ruminantium encodes a bifunctional enzyme involved in the synthesis of vitamin B12. Gene. 2001;281(1-2):63-70. Anderson PJ. Cobalt Accumulation and Vitamin B12 Biosynthesis in Selenomonas ruminatium. Doctoral Thesis. University of New England; 2001.