个人简介

After completing her BSc(hons 1) in Molecular Biology and Genetics at Flinders University in 1994, Dr Wallace commenced a PhD under the supervision of renowned geneticists Grant Sutherland and John Mulley. During her PhD, Dr Wallace discovered the world's first gene known to cause a form of idiopathic generalized epilepsy. Following the awarding of her PhD from the University of Adelaide in 1998, she worked with Bionomics Ltd to develop drug targets and genetic tests for epilepsy. In 2002, Dr Wallace was appointed Assistant Professor at the University of Tennessee Health Science Center, where she extended her genetics experience to include the analysis of mouse epilepsy models. In 2005 Dr Wallace joined the Queensland Brain Institute as the inaugural Ross Maclean Senior Research Fellow. Her research focused on elucidating molecular mechanisms of diseases of the central nervous system, including epilepsy, motor neuron disease and dementia. In 2014 she joined CSU as a Lecturer in Anatomy and Physiology.

研究领域

Anatomy & Physiology

Motor Neuron Disease (MND) is a rare, incurable disorder with late onset. Although most MND cases are not familial, a small percentage are due to the inheritance of particular genes. Dr Wallace is using transgenic mice to understand the mechanisms involved and to test potential treatments. TDP-43 is an RNA binding protein involved in gene regulation. Genetic mutations associated with both familial and sporadic cases of MND have been identified in TDP-43. The function of TDP-43 in the nervous system is largely unknown and its role in the pathogenesis of MND remains unclear. The aim of Dr Wallace's current research is to determine how abnormal TDP-43 leads to loss of motor neurons in MND patients. Recently she has identified genes that are regulated by TDP-43 and is now determining whether those genes are altered in MND patients with TDP-43 mutations. These studies will improve our understanding of what causes MND and provide rational targets for new therapies.

近期论文

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Walker AK, Soo KY, Sundaramoorthy V, Parakh S, Ma Y, Farg MA, Wallace RH, Crouch PJ, Turner BJ, Horne MK, Atkin JD. ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation. PLoS One 8(11):e81170 (2013). Hawi Z, Matthews N, Wagner J, Butler TJ, Wallace RH, Vance A. DNA variation in the SNAP25 gene confers risk to ADHD and is associated with reduced expression in prefrontal cortex. PLoS One 8(4):e60274 (2013). Narayanan NK, Mangelsdorf M, Panwar A, Butler TJ, Noakes PG, Wallace RH. Identification of RNA bound to the TDP-43 ribonucleoprotein complex in the adult mouse brain. Amyotrophic Lateral Sclerosis Frontotemporal Degeneration 14(4):252-60 (2013). Hawi Z, Matthews N, Barry E, Kirley A, Wagner J, Wallace RH, Heussler HS, Vance A, Gill M, Bellgrove MA. A high density linkage disequilibrium mapping in 14 noradrenergic genes: evidence of association between SLC6A2, ADRA1B and ADHD. Psychopharmacology 225:895-902 (2013). Matthews N, Vance A, Cummins TDR, Wagner J, Connolly A, Yamada J, Lockhart PJ, Panwar A, Wallace RH, Bellgrove MA. The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD. Behavioral and Brain Functions 8:25 (2012). Cowin GJ, Butler TJ, Kurniawan ND, Watson C, Wallace RH. Magnetic resonance microimaging of the spinal cord in the SOD1 mouse model of amyotrophic lateral sclerosis detects motor nerve root degeneration. NeuroImage 58(1):69-74 (2011). Underwood CU, Kurniawan ND, Butler T, Cowin GJ, Wallace RH. Non-invasive diffusion tensor imaging detects white matter degeneration in the spinal cord of a mouse model of amyotrophic lateral sclerosis. NeuroImage 55(2):455-61 (2011). Dibbens LM, Michelucci R, Gambardella A, Andermann F, Rubboli G, Bayly MA, Joensuu T, Vears DF, Franceschetti S, L Canafoglia L, Wallace R, Bassuk AG, DA, Tassinari CA, Andermann E, Lehesjoki AE, Berkovic SF. SCARB2 mutations in progressive myoclonus epilepsy (PME) without renal failure. Annals of Neurology 66:532-536 (2009). Wallace RH, Freeman JL, Shouri MR, Izzillo PA, Rosenfeld JV, Mulley JC, Harvey AS, Berkovic SF. Somatic mutations in GLI3 can cause sporadic hypothalamic hamartoma and gelastic seizures. Neurology 70:653-656 (2008). Bassuk AG, Wallace RH, Buhr A, Buller AR, Afawi Z, Shimojo M, Miyata S, Chen S, Gonzalez-Alegre P, Griesbach HL, Wu S, Nashelsky M, Vladar EK, Antic D, Ferguson PJ, Cirak S, Voit T, Scott MP, Axelrod JD, Gurnett C, Daoud AS, Kivity S, Neufeld MY, Mazarib A, Straussberg R, Walid S, Korczyn AD, Slusarski DC, Berkovic SF, El-Shanti HI. A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. American Journal of Human Genetics 83:1-10 (2008). Walker TJ, White A, Black DM, Wallace RH, Sah P, Bartlett PF. Latent stem and progenitor cells in the hippocampus are activated by neural excitation. Journal of Neuroscience 28:5240-7 (2008). Xu et al Xu R, Thomas EA, Gazina EV, Richards KL, Quick M, Wallace RH, Harkin LA, Heron SE, Berkovic SF, Scheffer IE, Mulley JC, Petrou S. Generalized epilepsy with febrile seizures plus-associated sodium channel beta1 subunit mutations severely reduce beta subunit-mediated modulation of sodium channel function. Neuroscience 148:164-74 (2007). Scheffer IE, Harkin LA, Grinton BE, Dibbens LM, Turner ST, Xu R, Jackson G, Adams J, Connellan M, Petrou S, Wellard RM, Briellmann RS, Wallace RH, Mulley JC, Berkovic SF. Temporal lobe epilepsy and GEFS+ phenotypes associated with SCN1B mutations. Brain 130:100-109 (2007). Berkovic SF, Mazarib A, Walid S, Neufeld MY, Manelis J, Nevo Y, Korczyn AD, Yin J, Xiong L, Pandolfo M, Mulley JC, Wallace RH. A new clinical and molecular form of Unverricht-Lundborg Disease localized by homozygosity mapping. Brain 128:652-658 (2005). Berkovic SF, Serratosa JM, Phillips HA, Xiong L, Andermann E, Díaz-Otero F, Gómez-Garre P, Martín M, Fernández-Bullido Y, Andermann F, Lopes-Cendes I, Dubeau F, Desbiens R, Scheffer IE, Wallace RH, Mulley JC, Pandolfo M. Familial Partial Epilepsy with Variable Foci: Clinical Features and Linkage to Chromosome 22q12. Epilepsia 45:1054-1060 (2004). Marini C, Scheffer IE, Crossland KM, Grinton BE, Phillips FL, McMahon JM, Turner SJ, Dean JT, Kivity S, Mazarib A, Neufeld MY, Korczyn AD, Harkin LA, Dibbens LM, Wallace RH, Mulley JC, Berkovic SF. Genetic architecture of idiopathic generalized epilepsy: clinical genetic analysis of 55 multiplex families. Epilepsia 45:467-478 (2004). Berkovic SF, Izzillo P, McMahon JM, Harkin LA, McIntosh AM, Phillips HA, Briellmann RS, Wallace RH, Mazarib A, Neufeld MY, Korczyn AD, Scheffer IE, Mulley JC. LGI1 mutations in temporal lobe epilepsies. Neurology 62:1115-9 (2004). Wallace RH, Hodgson BL, Grinton BE, Gardiner RM, Robinson R, Rodriguez-Casero V, Sadleir L, Morgan J, Harkin LA, Dibbens LM, Yamamoto T, Mulley JC, Andermann E, Berkovic SF, Scheffer IE. Sodium channel alpha-1 subunit mutations in Severe Myoclonic Epilepsy of Infancy and Infantile Spasms. Neurology 61:765-769 (2003). Marini M, Harkin L, Wallace RH, Mulley JC, Scheffer IE, Berkovic SF. Childhood absence epilepsy and febrile seizures: a family with a GABA-A receptor mutation. Brain 126:230-240 (2003). Wallace RH, Scheffer IE, Parasivam G, Barnett S, Wallace GG, Sutherland GR, Berkovic SF, Mulley JC. Generalised epilepsy with febrile seizures plus: Mutation of the sodium channel subunit SCN1B and evidence for a founder effect. Neurology 58:1426-1428 (2002). Bowser DN, Wagner DA, Czajkowski C, Cromer BA, Parker MW, Wallace RH, Harkin LA, Mulley JC, Marini C, Berkovic SF, Williams DA, Jones MV, Petrou S. Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation (gamma2-R43Q) found in human epilepsy. Proc Natl Acad Sci 99:15170-15175 (2002).