个人简介

BSc , University College Dublin (1988), BSc (Hons) North East Surrey college of Technology (1991), PhD University College London (2001). Diploma in applied project management, Institute of Project Management, Ireland (2006)

研究领域

Microbiology

Research projects currently ongoing in my laboratory include Characterisation of Equine Mesenchymal stem cells (In collaboration with Dr Jane Quinn and Prof Bryan Hilbert, School of Animal and Veterinary Sciences, CSU). Development of non -integrating lentiviral vectors for gene modification of stem cells. Molecular characterisation of equine adenovirus (In collaboration with Dr Thiru Vanniasinkam and Dr Heather Cavanagh)

近期论文

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Splice variants of the Alzheimer's disease beta-secretase, BACE1.Holsinger RM, Goense N, Bohorquez J, Strappe P. Neurogenetics. 2012 Nov 11. [Epub ahead of print] Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord.Donnelly EM, Madigan NN, Rooney GE, Knight A, Chen B, Ball B, Kinnavane L, Garcia Y, Dockery P, Fraher J, Strappe PM, Windebank AJ, O'Brien T, McMahon SS. Cytotherapy. 2012 Nov;14(10):1235-44. Strappe P and Kalle, W. Atomic Force Microscopy in cytogenetics. Micron 2012 43, 1224-31 McMahon SS, Nikolskaya N, Ni Choileain S, Hennessy N, O’Brien T, Strappe P, Gorelov A, Rochev Y. Thermosensitive Hydrogel for prolonged delivery of lentiviral vector expressing Neurotrophin-3 in vitro. J Gene Med. 2011 (11):591-601 McGinley L, McMahon J, Strappe P, Barry F, Murply M, O’Toole D, O’Brien T. Lentiviral vector mediated modification of mesenchymal stem cells and enhanced survival in an in vitro model of ischaemia. Stem Cell Res Ther 2011 2(2):12 EM Donnelly PM Strappe*, L M McGinley , N Madigan , E Gurtz, G Rooney, A J Windebank , J Fraher , P Dockery , T O’Brien , S McMahon. Lentiviral vector mediated knockdown of the NG2 proteoglycan or expression of Neurotrophin 3 promotes neurite outgrowth in a cell culture model of the glial scar. J Gene Med 2010(11):863-72.*Denotes Joint First author and corresponding author Krupka N, Strappe P, Gotz J, Ittener LM. Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent proteins. Plasmid, 63, 155-60, 2010. Impact Factor 1.81 Eglon MN, Duffy, AM, O’Brien T Strappe PM. Purification of adenoviral vectors by combined anion exchange and gel filtration chromatography. J Gene Med,11, 978-89, 2009. Impact Factor 3.54 Gibert JL, Purcell J, Strappe P, McCabe M, O'Brien T, O'Dea S. Comparative evaluation of viral, nonviral and physical methods of gene delivery to normal and transformed lung epithelia cells. Anticancer Drugs, 19, 783-788, 2008 McMahon J, O’Shea C, Conroy S, Howard L, Murphy M, Barry F, Strappe PM, O’Brien T. A comparison of viral vectors for efficient transduction of adult mesenchymal stem cells. Stem Cells and Development, 15, 78, 702-8 2006 Breen A, Strappe P, Anilkumar TV, O’ Brien T, Pandit A.Optimisation of a Fibrin Scaffold for Sustained Release of an Adenoviral Gene Vector. J Biomed Mater Res, 78, 702-708, 2006 Duffy AM, O’Doherthy AM. O’Brien T, Strappe PM. Purification of Adenovirus and Adeno-associated virus: Comparison of novel membrane based technology to conventional techniques. Gene Therapy, 12, S62-72, 2005 Strappe PM. Hampton DW, Brown D, Gonzales BC, Caldwell M, Fawcett JW, Lever AM. Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage. Retrovirology. 2005, 2 (1):55. Strappe PM, Hampton DW, Cachon-Gonzalez B, Fawcett JW, Lever A. Delivery of a Lentiviral vector in a Pluronic F127 gel to cells of the central nervous system. European Journal of pharmaceutics and Biopharmaceutics, 61, 126-133 2005. Poole E, Strappe P, Mok HP, Hicks R and Lever AML. HIV-1 Gag-RNA interaction occurs at a Perinuclear / Centrosomal Site; Analysis by Confocal Microscopy and FRET. Traffic. 2005, 6, 741-755. Sen S, Strappe PM, O’Brien T. Gene Transfer in endothelial dysfunction and hypertension. Methods Mol Med. 2004, 108, 299-314. Lever AM, Strappe PM, Zhao J Lentiviral vectors. J Biomed Sci. 2004 ,4: 439-49. Strappe PM, Greatorex J, Thomas J, Biswas P, McCann E, Lever AM. The packaging signal of simian immunodeficiency virus is upstream of the major splice donor at a distance from the RNA cap site similar to that of human immunodeficiency virus types 1 and 2. J Gen Virol. 2003,84, 2423-30. Zhao C, Strappe PM, Lever AM, Franklin RJ. Lentiviral vectors for gene delivery to normal and demyelinated white matter. Glia. 2003,42:59-67. Emery VC, Atkins MC, Bowen EF, Clark DA, Johnson MA, Kidd IM, McLaughlin JE, Strappe PM, Griffiths PD. Interactions between beta-herpesviruses and human immunodeficiency virus in vivo: evidence for increased human immunodeficiency viral load in the presence of human herpesvirus 6. J Med Virol. 1999,57:278-82.