个人简介

BSc (Hons 1) in Zoology & Biochemistry, School of Biological Sciences, Faculty of Science, UNSW, Sydney, 1988. Ph.D. in Molecular Cell Biology, School of Pathology, Faculty of Medicine, University of New South Wales, Sydney. 1996.

研究领域

Biochemistry and Cell Biology

Signal transduction Proteomics technologies and their application Cancer research The role of PGRMC1 in cancer signalling and cellular metabolic regulation Human ageing

近期论文

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Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, Mach RH, Craven R, Head E, LeVine H (III), Spires-Jones TL, Catalano SM. 2014. Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity. PloSOne. 9:e111899. http://dx.doi.org/10.1371/journal.pone.0111899 Drozdowicz-Tomsia K, Anwer AG, Cahill MA, Madlum KN, Maki AM, Baker ME, Goldys EM. 2014. Multiphoton FLIM imaging reveals free to bound NADH ratio changes associated with metabolic inhibition. J Biomedical Optics. 19:86016. http://www.ncbi.nlm.nih.gov/pubmed/25140884 Zhou J, Yu Q, Chen R, Seeger H, Fehm T, Cahill MA, Mueck AO, Neubauer H. 2013. Medroxyprogesterone acetate-driven increase in breast cancer risk might be mediated via cross-talk with growth factors in the presence of progesterone receptor membrane component-1. Maturitas. 76:129-33. http://www.ncbi.nlm.nih.gov/pubmed/23856385 Neubauer H, Ruan X, Schneck H, Seeger H, Cahill MA, Liang Y, Mafuvadze B, Hyder SM, Fehm T, Mueck AO. 2013. Overexpression of progesterone receptor membrane component 1: possible mechanism for increased breast cancer risk with norethisterone in hormone therapy. Menopause. 20:504-10. http://www.ncbi.nlm.nih.gov/pubmed/23615641 Neubauer H, Ruan X, Schneck H, Seeger H, Cahill MA, Liang Y, Mafuvadze B, Hyder SM, Fehm T, Mueck AO. 2013. Overexpression of progesterone receptor membrane component 1: possible mechanism for increased breast cancer risk with norethisterone in hormone therapy. Menopause. 20(5):504-10. http://www.ncbi.nlm.nih.gov/pubmed/23856385 Schneck H, Ruan X, Seeger H, Cahill MA, Fehm T, Mueck AO, Neubauer H. 2013. Membrane-receptor initiated proliferative effects of dienogest in human breast cancer cells. Gynecol Endocrinol. 29:160-3. http://www.ncbi.nlm.nih.gov/pubmed/23116217 Ruan X, Schneck H, Schultz S, Fehm T, Cahill MA, Seeger H, Chen R, Yu Q, Mueck AO, Neubauer H. 2012. Nomegestrol acetate sequentially or continuously combined to estradiol did not negatively affect membrane-receptor associated progestogenic effects in human breast cancer cells. Gynecol Endocrinol. 28:863-6. http://www.ncbi.nlm.nih.gov/pubmed/22494101 Ruan X, Neubauer H, Yang Y, Schneck H, Schultz S, Fehm T, Cahill MA, Seeger H, Mueck AO. 2012. Progestogens and membrane-initiated effects on the proliferation of human breast cancer cells. Climacteric. 15:467-72 http://www.ncbi.nlm.nih.gov/pubmed/22335423 Neubauer H, Chen R, Schneck H, Knorrp T, Templin MF, Fehm T, Cahill MA, Seeger H, Mueck AO. 2011. New insight on a possible mechanism of progestogens in terms of breast cancer risk. Horm Mol Biol Clin Invest. 6:185-92. http://dx.doi.org/10.1515/HMBCI.2010.082 Neubauer H, Yang Y, Seeger H, Fehm T, Cahill MA, Tong X, Alfred O Mueck AO. 2011. The presence of a membrane-bound progesterone receptor sensitizes the estradiol-induced effect on the proliferation of human breast cancer cells. Menopause. 18:845-50Published online26/4/2011. http://www.ncbi.nlm.nih.gov/pubmed/21532513 Bryant KJ, Bidgood MJ, Lei P-W, Taberner M, Salom C, Kumar V, Lee L, Church WB, Courtenay B, Smart BP, Gelb MH, Cahill MA, Graham GG, McNeil HP, Scott KF. 2011. A bifunctional role for Group IIa secreted phospholipase A2 in human rheumatoid fibroblast-like synoviocyte arachidonic acid metabolism. J Biol Chem. 286:2492-503. http://www.ncbi.nlm.nih.gov/pubmed/21068383 Neubauer H, Adam G, Seeger H, Mueck AO, Solomayer E, Wallwiener D, Cahill MA, Fehm T. 2009. Membrane-Initiated effects of progesterone on proliferation and activation of VEGF in breast cancer cells. Climacteric. 12:230-9. http://www.ncbi.nlm.nih.gov/pubmed/19340614 Langer R, Ott K, Specht K, Becker K, Lordick F, Burian M, Herrmann K, Schrattenholz A, Cahill MA, Schwaiger M, Hofler H, Wester HJ. 2008. Protein expression profiling in esophageal adenocarcinoma patients indicates association of heat-shock protein 27 expression and chemotherapy response. Clin Cancer Res. 14:8279-87. http://www.ncbi.nlm.nih.gov/pubmed/19088045 Neubauer H, Clare S, Wozny W, Schwall GP, Poznanovic S, Stegmann W, Vogel U, Sotlar K, Wallwiener D, Kurek R, Fehm T, Cahill MA. 2008. Breast cancer proteomics reveals correlation between Estrogen Receptor status and differential phosphorylation of PGRMC1. Breast Cancer Research. 10:R85. http://www.ncbi.nlm.nih.gov/pubmed/18922159 Cahill MA. 2007. Progesterone Receptor Membrane Component 1: an integrative review. J Ster Biochem Mol Biol, 105:16-36. http://www.ncbi.nlm.nih.gov/pubmed/17583495 Cahill MA, Vogt JA, Servos J, Wozny W, Schwall GP, Groebe K, Schrattenholz A, Stegmann W. 2007. Metabolically stable isotope labeling prior to electrophoretic protein separation reveals differences in fractional synthesis rates between mitochondrial aldehyde dehydrogenase isoforms. J Chromatogr A, 1161:67-70. http://www.ncbi.nlm.nih.gov/pubmed/17466314 Wozny W, Schroer K, Schwall GP, Poznanovic S, Stegmann W, Dietz K, Rogatsch H, Schaefer G, Huebl H, Klocker H, Schrattenholz A, Cahill MA. 2007. Differential radioactive quantification of protein abundance ratios between benign and malignant prostate tissues: Cancer association of annexin A3. Proteomics, 7:313-322. http://www.ncbi.nlm.nih.gov/pubmed/17205602 Hunzinger C, Wozny W, Schwall GP, Poznanovic S, Stegmann W, Zengerling H, Schoepf R, Groebe K, Cahill MA, Osiewacz HD, Jägemann N, Bloch M, Dencher NA, Krause F, Schrattenholz A. 2006. Comparative Profiling of the Mammalian Mitochondrial Proteome: Multiple Aconitase-2 Isoforms including N-formylkynurenine modifications as part of a protein biomarker signature for reactive oxidative species. J Proteome Res, 5:625-33. http://www.ncbi.nlm.nih.gov/pubmed/16512678 Neubauer H, Clare SE, Kurek R, Fehm T, Wallwiener D, Sotlar K, Nordheim A, Wozny W, Schwall GP, Poznanovic S, Sastri C, Hunzinger C, Stegmann W, Schrattenholz A, Cahill MA. 2006. Breast cancer proteomics by laser capture microdissection, sample pooling, 54 cm immobilised pH gradient isoelectric focussing, and differential iodine radioisotope detection. Electrophoresis, 27:1840-52. http://www.ncbi.nlm.nih.gov/pubmed/16645950 Poznanovic P, Wozny W, Schwall GP, Sastri C, Hunzinger C, Stegmann W, Schrattenholz A, Buchner A, Gangnus R, Burgemeister R, Cahill MA. 2005. Differential radioactive proteomic analysis of microdissected renal cell carcinoma tissue by 54 cm isoelectric focusing in serial immobilized pH gradient gels. J Proteome Res, 4:2117-25. http://www.ncbi.nlm.nih.gov/pubmed/16335957