个人简介

Wouter Kalle graduated in 1988 as Drs. in Biology from the State University of Utrecht in the Netherlands. In 1989, he started working as a PhD student at the Department of Radiation Genetics and Chemical Mutagenesis at the University of Leiden in the Netherlands. The title of his PhD thesis is 'Immunochemical Analysis of UV-induced repair events in specific DNA sequences of mammalian cells'. He finished his PhD studies in 1993 and started working as a post doc at the Department of Cytochemistry and Cytometry at the University of Leiden in the Netherlands. During this period he worked on Atomic Force Microscopy, In situ Hybridization and Immuno-cytochemistry. He took up his present position as lecturer in Molecular Biology in the School of Biomedical Sciences in 1997. His research interests are focused on evolutionary mechanisms in behaviour. He successfully supervised a number of Honours- and PhD students which has resulted in journal articles in international peer reviewed journals. Since 2007 he is Program Leader for the Bachelor of Medical Science.

研究领域

Biochemistry and Cell Biology

Research interests: DNA Structure and Repair DNA repair in specific genes DNA damage DNA damage prevention Microscopy Cancer Evolution Evolution of Behaviour Epigenetics

近期论文

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Yim Tong Szeto, Kam Shing Wong, Wouter Kalle, Sok Cheon Pak. (2013) Therapeutic properties of ginseng and the application of comet assay on antioxidative study TANG (Humanitas Traditional Medicine) accepted for Publication Yim Tong Szeto, Rick Sui Cheung Tse, Iris F. F. Benzie, Wouter Kalle and Sok Cheon Pak (2013) An In Vitro Study of Sanchi (Panax pseudoginseng) for its DNA Protective Effect Food and Agricultural Immunology accepted for publication Yim-Tong Szeto, Ngok-Fung Cheng, Sok-Cheon Pak, Wouter Kalle (2013) Genoprotective effect of the Chinese herbal decoction xiao jian zhong tang. Natural product communications 8(3) pp 389-392. Yim Tong Szeto, Po Chun Lau, Wouter Kalle, Sok Cheon Pak (2013) Direct human DNA protection by Coriolus versicolor (Yunzhi) extract. Pharmaceutical Biology 4 pp 851-855 Yim Tong Szeto, Tai Lun To, Sok Cheon Pak, Wouter Kalle 2013) A study of DNA protective effect of orange juice supplementation. Applied Physiology Nutrition and Metabolism 38(5) pp 533-536. Yim Tong Szeto, Kit Yee Lee, Wouter Kalle and Sok Cheon Pak (2013) Protective effect of grape seed extracts on human lymphocytes: a preliminary study Physiology, Nutrition, and Metabolism 38(3) pp 275-279 Phillip Bwititi, Uba Nwose, Sharon Nielsen, Henk Ruven, Wouter Kalle, Ross Richards and Eugene Butkowski (2012) Serum uric acid and albumin levels and estimated glomerular filtration rate: oxidative stress considerations Australian Journal of Medical Science 33 no 3 pp 82-87 Wouter Kalle and P. Strappe (2012) Atomic Force Microscopy on Chromosomes, Chromatin and DNA: a review Micron 43 pp 1224–1231 Yim Tong Szeto, Shirley Chin Yee Wong, Julia Mai Wing Mong, Iris F.F. Benzie, Wouter Kalle Sok Cheong Pak (2011) In vitro anti-oxidation activity and genoprotective effect of selected Chines medicinal herbs. The American Journal of Chinese Medicine 39 pp 827-838 Jason C. Steel, Heather M.A. Cavanagh, Mark A. Burton, Mones S. Abu-Asab, Maria Tsokos, John C. Morris and Wouter H.J. Kalle (2007) Increased tumor localization and reduced immune response to adenoviral vector formulated with the liposome DDAB/DOPE. European Journal of Pharmaceutical Sciences 30 pp 398-405 Thordarson P, Atkin R, Kalle WJH, Warr GG, Braet F (2006) Developments in using scanning probe microscopy to study molecules on surfaces - from thin films and single-molecule conductivity to drug-living cell interactions. Aust J Chem 59 pp 359-375. Jason C. Steel, Heather M.A. Cavanagh, Mark A. Burton, Daniel J. Dingwall and Wouter H.J. Kalle (2005). Modification of liposomal concentration in liposome/adenoviral complexes allows significant protection of adenoviral vectors from neutralising antibody, in vitro Journal of Virological Methods, 126 pp 31-36 JC Steel, HMA Cavanagh, MA Burton, WHJ Kalle (2005) Microsphere Delivery of Adenoviral-Liposome Complexes Reduces Adenoviral Immunogenicity and Allows Successful Re-Administration of the Virus without Loss of Gene Expression Efficiency Molecular Therapy S11 p Jason C. Steel, Wouter H. Kalle, Daniel Dingwall, Heather Cavanagh, Mark A. Burton (2004). Pre-treatment with a non-therapeutic dose of cisplatin increases solid tumour response to liposomal-p53 gene therapy. Cancer Therapy 2 pp 239-244 Jason C. Steel, Heather M. A. Cavanagh , Mark A. Burton , Daniel Dingwall and Wouter H. J. Kalle (2004). In-vitro evaluation of ion-exchange microspheres for the sustained release of liposomal–adenoviral conjugates. Journal of Controlled Release 95 pp 601-611 MY Kwan, W Kalle, GTC Lau, JKC Chan (2004) Is gliomatosis peritonei derived from the associated ovarian teratoma? Human Pathology, 35 pp 685-688 Jason C. Steel, Heather M.A. Cavanagh, Mark A. Burton and Wouter H.J. Kalle (2004). Microsphere–liposome complexes protect adenoviral vectors from neutralising antibody without losses in transfection efficiency, in-vitro. Journal of Pharmacy and Pharmacology 56 pp. 1371-1378 Melanie Cochrane, Wouter Kalle, Paul Roffey & Helen Moriarty (2002). The detection of Chlamydia pneumoniae in atherosclerotic plaques of Australian subjects. Pathology 34 pp 270-274 Crispin R. Dass, Todd L. Walker, Wouter H.J. Kalle and Mark Burton (2000) A microsphere-lipoplex (microplex) vector for targeted gene therapy of cancer. II. N Vivo biodistribution studyin a solid tumor model. Drug Delivery, 7, pp 15-20 Crispin R. Dass, Todd L. Walker, Wouter H.J. Kalle and Mark Burton (1999) A microsphere-lipoplex (microplex) vector for targeted gene therapy of cancer. I. Construction and in vitro evaluation Drug Delivery, 6, pp 259-270