研究领域

Characterization of micronised particles for respiratory delivery Development of controlled release dosage forms Surface-tailored biodegradable polymers for maximising drug delivery from dry powder inhaler (DPI) formulation Preparation and in-vitro evaluation of a polymer based controlled release DPI formulation for pulmonary delivery Powder technology Development of a DPI device for efficient delivery of therapeutics into deep lungs

Development of drug loaded biodegradable polymer based controlled release micro/nanoparticles for pulmonary delivery The aim of this work is to research the principles underlying development of polymer-based controlled release dry powder inhaler (DPI) formulations and so optimise the performance in a typical powder formulation of a model drug for inhalation. This study can be expected to provide a better understanding in developing an optimized DPI formulation with controlled release profile for systemic action. Studies on the efficient respiratory delivery of drugs from Dry Powder Inhaler (DPI) formulations using biodegradable polymers as carriers This project involves in drug delivery from dry powder inhaler formulations for asthma patients. The outcome of this project will be to enable the development of suitable carrier powders for dry powder inhalers formulations for efficient delivery of drugs into the deep lungs. Maximization of drug delivery from dry powder inhaler (DPI) Formulation This project deals with the maximization of respiratory delivery of drug from dry powder inhaler formulation. The outcome of this study will help get a better understanding of the factors controlling in efficient delivery of drugs for DPI formulations.

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Islam, Nazrul & Ferro, Vito (2016) Recent advances in chitosan-based nanoparticulate pulmonary drug delivery. Nanoscale, 8(30), pp. 14341-14358. Muhsin, Mohammad, George, Graeme, Beagley, Kenneth, Ferro, Vito, Wang, Hui, & Islam, Nazrul (2016) Effects of chemical conjugation of L-leucine to chitosan on dispersibility and controlled release of drug from a nanoparticulate dry powder inhaler formulation. Molecular Pharmaceutics, 13(5), pp. 1455-1466. Muhsin, Mohammad, George, Graeme A., Beagley, Kenneth, Ferro, Vito, Armitage, Charles, & Islam, Nazrul (2014) Synthesis and toxicological evaluation of a chitosan‑L‑leucine conjugate for pulmonary drug delivery applications. Biomacromolecules, 15, pp. 3596-3607. Islam, Nazrul, Tuli, Rinku A., George, Graeme A., & Dargaville, Tim R. (2014) Colloidal drug probe : Method development and validation for adhesion force measurement using Atomic Force Microscopy. Advanced Powder Technology, 25, pp. 1240-1248. Tuli, Rinku, Dargaville, Tim R., George, Graeme A., & Islam, Nazrul (2013) Dry powder inhaler formulations-effect of polymer carrier size on the drug dispersion. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 26(5), A-3.