Moloney, M.G. - University of Oxford - Department of Chemistry

研究领域

My interests are concerned with the application of organic chemistry to the synthesis of biologically relevant compounds and the functionalisation of materials. Synthesis of Bioactive Compound Libraries Natural products exhibit wide biological activities, and therefore provide inspiration for the development of new drugs and medicinally active compounds. An important subset contain pyrrolidine and piperidine rings as a core structure, and are of considerable importance because of their antibiotic, antibacterial, antifungal and anticancer properties. We have developed synthetic methodology allowing simple, short, efficient and versatile access to such heterocycles based upon the manipulation of bicyclic ring templates, which allows control of both relative and absolute stereochemistry, and moreover gives several points of diversity on the ring periphery for further derivatisation. Current efforts focus on the application of this methodology for the rapid preparation of chiral heterocyclic libraries for the identification of new antibacterials and anticancer agents. Functionalisation of Materials We have developed technology for the chemical modification of material surfaces under mild conditions; it permits the introduction of useful functionality on to what would otherwise be considered to be inert materials and gives a chemically irreversible modification to the polymer. We have shown that highly reactive diarylcarbene intermediates, easily generated under thermolytic or photolytic conditions, can be used for the modification of a wide variety of polymers, including natural (cotton) as well as synthetic materials (polystyrene, polyethylene, polyethyleneterephthalate, nylon as well as low surface energy materials such as polypropylene and PTFE), to introduce a range of surface activity, including colour, fluorescence, hydrophilicity/hydrophobicity, antibacterial function and adhesive modifications. The methodology is intrinsically flexible, being applicable to powders, beads, films and sheets, as well as woven and non-woven fabrics. The modification leads to a surface coverage of 5-20% of the surface area, but is not a simple molecular monolayer; rather it extends to the nano-dimension, but does not lead to surface film formation, surface degradation or other visible change in the material surface. Current research effort is focused on elaboration on the technology for different macroscopic effects, and for the control of the material interface with biological systems, suitable for application in biomedical devices, sensors and implants.

近期论文

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"Synthesis and antibacterial activity of monocyclic 3-carboxamidotetramic acids", Y.-C. Jeong and M. G. Moloney, Beilstein J. Org. Chem., 2013, 9, 1899-1906 [Invited submission]. "Post-Polymerization Modification of Materials using Diaryldiazomethanes: Changes to Surface Macroscopic Properties", C.L. Bagwell, D.M.L. Leonard, J.-P. Griffiths, M. G. Moloney, N. J. Stratton and D.P. Travers, Macromol. React. Eng., 2013, 10.1002/mren.201200088 [Invited submission]. "Chiral Bicyclic Tetramates as Non-Planar Templates for Chemical Library Synthesis", M. Anwar and M.G. Moloney, Chem. Biol. Drug. Des., 2013, 81, 645-649. "Routes to Kaitocephalin Core", N. Chandan and M.G. Moloney, Tetrahedron Lett., 2013, 54, 1987-1990. "Natural product inspired antibacterial tetramic acid libraries with dual enzyme target activity", Y.-C. Jeong, M. Anwar, M. G. Moloney, Z. Bikadi and E. Hazai, Chem. Sci., 2013, 4, 1008-1015. "Surface Functional Polymers by Post-Polymerisation Modification using Diarylmethylenes: Metal Cation Catch and Release", A. Aphaiwong, M. Christlieb and M. G. Moloney, J. Mater. Chem., 2012, 22, 24627-24636. "Antimicrobial compounds", Y.-C. Jeong and M. G. Moloney, UK Patent Application No 1211202.5; Isis Innovation Limited, PCT application (2012). "Antimicrobial compounds", Y.-C. Jeong and M. G. Moloney, UK Patent Application No 1211203.3; Isis Innovation Limited, PCT application (2012). "Direct access to pyrrolines by nucleophilic substitution at nitrogen", N. Chandan and M. G. Moloney, Org. Biomol. Chem., 2012, 10, 7863-7868. "Electron Promotion by Surface Functional Groups of Single Wall Carbon Nanotube to Overlying Metal Particle in Fuel Cells Catalyst", P. Luksirikul, K. Tedsree, M. G. Moloney, M. L. H. Green and S. C. E. Tsang, Angew. Chem., 2012, 51, 6998-7001. "Control of Wetting Behaviour using Modifications of Surface Chemical Functionality", J.-P. Griffiths, D. M. L. Leonard, M. G. Moloney and N. J. Stratton, J. Mol. Eng. Mater., 2012, 1(1), 1250002 [Invited submission]. "Post-Polymerisation Modification of Surface Chemical Functionality and its Effect on Protein Binding", C. Choong, J. Foord, J.-P. Griffiths, E. M. Parker, L. Baiwen, M. Bora and M. G. Moloney, New J. Chem., 2012, 36, 1187–1200 [Hot Article]. "Synthesis and Evaluation of the Antibacterial Activity of the Functionalised Pyroglutamate Core of the Oxazolomycins", S. Chau, P. J. Fryer, M. G. Moloney and P. C. Trippier, Org. Biomol. Chem., 2012, 10, 3472. "Ultrasensitive Pb(II) Potentiometric Sensor Based on Copolyaniline Nanoparticles in Plasticizer-Free Membrane with Long Lifetime", X.-G. Li, H. Feng, M.-R. Huang, G.-L. Gu and M.G. Moloney, Anal. Chem., 2012, 84(1), 134-140. "Synthesis and anti-bacterial activities of some novel pyrazolobenzothiazine-based chalcones and their pyrimidine derivatives", M. H. Bukhari, H. L. Siddiqui, M. Ahmad, T. Hussain and M. G. Moloney, Med. Chem. Res., 2012, 21, 2885-2895. "Sidewall functionalisation of single-walled carbon nanotubes by addition of diaryl carbene derivatives", P. Luksirikul, B. Ballesteros, G. Tobias, M.G. Moloney and M. L. H. Green, J. Mater. Chem., 2011, 21, 19080. "Synthesis and antibacterial activity of bicyclic lactam-lactones", P. Angelov, Y.-C. Jeong, K. Hosamani, M. G. Moloney, A. Thompson and M. Yaqoob, Synlett., 2011, 15, 2181-2184. "Spirocyclic Bislactams derived from Pyroglutamic Acid", T. Hill, P. Kocis, M. G. Moloney and R. Stevenson, Org. Biomol. Chem., 2011, 9 (20), 7042 - 7056. "Synthesis and Multifunctionality of Self-Stabilized Polyaminoanthraquinone Nanofibrils", X.-G. Li, H. Li, M.-R. Huang, M. G. Moloney, J. Phys. Chem., 2011, 115, 9486-9497. "Control of chemoselectivity in Dieckmann ring closures leading to tetramic acids", Y.-C. Jeong, M. Anwar, T. M. Nguyen, B. S. W. Tan, C. L. L. Chai and M. G. Moloney, Org. Biomol. Chem., 2011, 9 (19), 6663 - 6669.