Lott, Bill - Queensland University of Technology - Nanotechnology and molecular science discipline

研究领域

Molecular Virology The study of molecular strategies and mechanisms employed by positive-sense single-stranded RNA viruses in the family Flaviviridae. Antiviral drug design Hepatitis C-specific antiviral design, targeting novel interactions between the viral genomic RNA and trans-acting viral and host factors. Temporal RNA structure and function Elucidating the role of temporal RNA secondary structure on the timing of essential viral functions.

近期论文

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Lott B, Doran MR, (2013) Do RNA viruses require genome cyclisation for replication?, Trends in Biochemical Sciences p350-355 Marsh JW, Lott B, Tyndall JD, Huston WM, (2013) Proteolytic activation of Chlamydia trachomatis HTRA is mediated by PDZ1 domain interactions with protease domain loops L3 and LC and beta strand beta 5, Cellular and Molecular Biology Letters p522-537 Babur B, Ghanavi P, Levett PA, Lott B, Klein TJ, Cooper-White JJ, Crawford RW, Doran MR, (2013) The interplay between chondrocyte redifferentiation pellet size and oxygen concentration, PLoS ONE p1-12 Kabiri Renani M, Kul B, Lott WB, Futrega K, Ghanavi P, Upton Z, Doran M, (2012) 3D mesenchymal stem/stromal cell osteogenesis and autocrine signalling, Biochemical and Biophysical Research Communications p142-147 Li D, Lott WB, Lowry KS, Jones AJ, Thu HM, Aaskov J, (2011) Defective interfering viral particles in acute dengue infections, PLoS ONE p1-12 Romero TA, Tumban E, Jun J, Lott WB, Hanley KA, (2006) Secondary Structure Of Dengue Virus Type 4 3 ' Untranslated Region: Impact Of Deletion And Substitution Mutations, Journal of General Virology p3291-3296 Dongsheng L, Lott W, Martyn J, Haqshenas G, Gowans EJ, (2004) Differential effects on the hepatitis C virus (HCV) internal ribosome entry site by vitamin B12 and the HCV core protein, Journal of Virology p12075-12081 Dongsheng L, Takyar ST, Lott W, Gowans EJ, (2003) Amino acids 1-20 of the hepatitis C virus (HCV) core protein specifically inhibit HCV IRES-dependent translation in HepG2 cells, and inhibit both HCV IRES- and cap-dependent translation in HuH7 and CV-1 cells, Journal of General Virology p815-825 Takyar ST, Gowans EJ, Lott W, (2002) Vitamin B12 stalls the 80 S ribosomal complex on the hepatitis C internal ribosome entry site, Journal of Molecular Biology p1-8 Lott W, Takyar S, Tuppen J, Crawford DH, Harrison M, Sloots T, Gowans EJ, (2001) Vitamin B12 and hepatitis C: Molecular Biology and Human Pathology, Proceedings of the National Academy of Sciences p4916-4921