BrendanHarley - 台湾清华大学

个人简介

Biography Brendan Harley is currently a Professor in Chemical and Biomolecular Engineering and a research theme leader in the Carl R. Woese Institute for Genomic Biology at the University of Illinois at Urbana-Champaign. Dr. Harley develops biomaterials that replicate the dynamic, spatially-patterned, and heterogeneous microenvironment found in the tissues and organs of our body. He and members of his lab use this approach to generate new insight regarding how biomaterial cues can instruct cell responses in the context of development, disease, and regeneration. Harley co-authored the book ‘Cellular materials in nature and medicine’ (Cambridge University Press, 2010) along with more than 100 peer-reviewed manuscripts. Harley has received funding from the NSF, NIH, American Cancer Society, the U.S. Army, and the AO Foundation. He recognized as a 2013 recipient of a NSF CAREER award, the 2014 Young Investigator Award from the Society for Biomaterials, and was elected a Fellow of the American Association for the Advancement of Science (2014). He co-founded UK-based Orthomimetics, Ltd. (acquired by TiGenix, Ltd.), currently performing Phase I clinical trials on a material to repair osteochondral defects in the knee. Professor Harley joined the department in 2008. He received his SB from Harvard University in 2000 and SM/ScD from MIT in 2002 and 2006. His post-doctoral studies were completed at the Joint Program in Transfusion Medicine at Boston Children’s Hospital. Education •Research Fellow, Joint Program in Transfusion Medicine, Children's Hospital Boston, 2006-2008 •Sc.D., Massachusetts Institute of Technology, 2006 •S.M., Massachusetts Institute of Technology, 2002 •S.B., Harvard University, 2000 Honors •Fellow, American Institute for Medical and Biological Engineering (AIMBE), 2019 •Campus Distinguished Promotion Award, University of Illinois, 2018. •Dean’s Award for Excellence in Research (Associate Professor); College of Engineering, University of Illinois, 2018. •Dean's and Provost’s Awards for Excellence in Undergraduate Teaching, University of Illinois, 2018. •Invited participant, Frontiers of Engineering, National Academy of Engineering, 2016. •Schaefer Faculty Scholar, University of Illinois, 2016 - 2019. •Fellow, Center for Advanced Study, University of Illinois at Urbana-Champaign, 2015 - 2016. •University of Illinois Campus Distinguished Promotion Award, 2015. •Fellow, American Association for the Advancement of Science (AAAS), 2014 •Young Investigator Award, Society for Biomaterials, 2014 •NSF CAREER award 2013 - 2018 •University of Illinois, Teachers Ranked as Excellent 2009 - present •Kirschstein National Research Service Award T32 Postdoctoral Fellowship, National Heart Lung and Blood Institute, NIH 2006-2008

研究领域

Pursues the fabrication, characterization, and testing of biomaterials for in vivo and in vitro tissue engineering applications.

近期论文

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•M.T. Ngo, B.A.C. Harley, ‘Perivascular signals alter global gene expression profile of glioblastoma and response to temozolomide in a gelatin hydrogel,’ Biomaterials, 2018. DOI: 10.1016/j.biomaterials.2018.06.013. •D.W. Weisgerber, D.J. Milner, H. Lopez-Lake, M. Rubessa, S. Lotti, K. Polkoff, R.A. Hortensius, C.L. Flanagan, S.J. Hollister, M.B. Wheeler, B.A.C. Harley, ‘A mineralized collagen-polycaprolactone composite promotes healing of a porcine mandibular ramus defect,’ Tissue Eng Part A, 24(11-12): 943-54, 2018. •J.C. Pence, K.B.H. Clancy, B.A.C. Harley, ‘Pro-angiogenic activity of endometrial epithelial and stromal cells in response to estradiol in gelatin hydrogels,’ Adv. Biosys., 1(9):1700056, 2017. •S. Pedron, J.S. Hanselman, M. Schroeder, J.N. Sarkaria, B.A.C. Harley, ‘Extracellular hyaluronic acid influences the efficacy of EGFR tyrosine kinase inhibitors in a biomaterial model of glioblastoma,’ Adv. Healthc. Mater., 6(21):1700529, 2017. •M.T. Ngo, B.A.C. Harley, ‘The influence of hyaluronic acid and glioblastoma cell co-culture on the formation of endothelial cell networks in gelatin hydrogels,’ Adv. Healthc. Mater., 6(22):1700687, 2017. •W.K. Grier, A.S. Moy, B.A.C. Harley, ‘Cyclic tensile strain enhances human mesenchymal stem cell Smad2/3 activation and tenogenic differentiation in anisotropic collagen-glycosaminoglycan scaffolds,’ Eur. Cell Mater., 33:227-39, 2017. •J.-S. Choi, B.A.C. Harley, ‘Marrow-inspired matrix cues rapidly affect early fate decisions of hematopoietic stem and progenitor cells,’ Sci. Adv., 3(1):e1600455, 2017. •B.P. Mahadik, N.A.K. Bharadwaj, R.H. Ewoldt, B.A.C. Harley, ‘Regulating dynamic signaling between hematopoietic stem cells and niche cells via a hydrogel matrix,’ Biomaterials, 125:54-64, 2017. •L.C. Mozdzen, A. Vucetic, B.A.C. Harley, ‘Modifying the strength and strain concentration profile within collagen scaffolds using customizable arrays of poly-lactic acid fibers,’ J. Mech. Behav. Biomed. Mater., 66:28-36, 2017. •X. Ren, V. Tu, D. Bischoff, D.W. Weisgerber, M.S. Lewis, D.T. Yamaguchi, T.A. Miller, B.A.C. Harley, J.C. Lee, ‘Nanoparticulate mineralized collagen scaffolds induce in vivo bone regeneration independent of progenitor cell loading or exogenous growth factor stimulation,’ Biomaterials, 89:67-78, 2016. •Z. Rahil*, S. Pedron*, X. Wang, T. Ha, B.A.C. Harley§, D.E. Leckband§, ‘Nanoscale mechanics guides cellular decision making,’ Integr. Biol. (Camb), 8(9):929-35, 2016. * co-first authors. § co-corresponding authors. •B.P. Mahadik, S. Pedron Haba, L.J. Skertich, B.A.C. Harley, ‘The use of covalently immobilized stem cell factor to selectively affect hematopoietic stem cell activity within a gelatin hydrogel,’ Biomaterials, 67:297-307, 2015. •X. Ren, D. Bischoff, D.W. Weisgerber, M.S. Lewis, V. Tu, D.T. Yamaguchi, T.A. Miller, B.A.C. Harley, J.C. Lee, Osteogenesis on nanoparticulate mineralized collagen scaffolds via autogenous activation of the canonical BMP receptor signaling pathway, Biomaterials, 2015. •S.R. Caliari, W.K. Grier, D.W. Weisgerber, Z. Mahmassani, M.D. Boppart, B.A.C. Harley, Collagen scaffolds incorporating coincident patterns of instructive structural and biochemical cues for osteotendinous junction engineering, Adv. Healthc. Mater., 2015. •S. Pedron, E. Becka, B.A.C. Harley, Spatially-gradated hydrogel platform as a three-dimensional engineered tumor microenvironment, Adv. Mater., 27(9):1567-72, 2015. •S.R. Caliari, E.A. Gonnerman, W.K. Grier, D.W. Weisgerber, J.M. Banks, A.T. Alsop, J.-S. Lee, R.C. Bailey, B.A.C. Harley, Collagen scaffold arrays for combinatorial screening of biophysical and biochemical regulators of cell behavior, Adv. Healthc. Mater., 4(1):58-64, 2015. •S.R. Caliari, B.A.C. Harley, Structural and biochemical modification of a collagen scaffold to selectively enhance MSC tenogenic, chondrogenic, and osteogenic differentiation, Adv. Healthc. Mater., 3(7):1086-96, 2014. •S.R. Caliari, L.C. Mozdzen, O.E. Armitage, M.L. Oyen, B.A.C. Harley, Periodically-perforated core-shell collagen biomaterials balance cell infiltration, bioactivity, and mechanical properties, J. Biomed. Mater. Res. Pt. A, 102(4):917-27, 2014. •B.P. Mahadik, T.D. Wheeler, L.J. Skertich, P.J.A. Kenis, B.A.C. Harley, Microfluidic generation of gradient hydrogels to modulate hematopoietic stem cell culture environment, Adv. Healthc. Mater., 3(3):449-458, 2014. •R.A. Hortensius, B.A.C. Harley, The use of bioinspired alterations in the glycosaminoglycan content of collagen-GAG scaffolds to regulate cell activity, Biomaterials, 34(31):7645-52, 201 •S. Pedron, E. Becka, B.A.C. Harley, Regulation of glioma cell phenotype in 3D matrices by hyaluronic acid, Biomaterials, 34(30):7408â€“17, 2013. •C. Nombela-Arrieta, G. Pivarnik, B. Winkel, K.J. Canty, B.A.C. Harley, J.E. Mahoney, J. Lu, A. Protopopov, L.E. Silberstein, Quantitative imaging of hematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment, Nat. Cell Biol., 15(5):533-543, 2013. •J.S. Choi, B.A. Harley, The combined influence of substrate elasticity and ligand density on the viability and biophysical properties of hematopoietic stem and progenitor cells, Biomaterials, 33(18):4460-4468, 2012. •S.R. Caliari, B.A.C. Harley, The effect of anisotropic collagen-GAG scaffolds and growth factor supplementation on tendon cell recruitment, alignment, and metabolic activity, Biomaterials, 32(23):5330-40, 2011. •T. Martin, S.R. Caliari, P. Williford, B.A. Harley*, R.C. Bailey*, The generation of biomolecular patterns in highly porous collagen-GAG scaffolds using direct photolithography, Biomaterials, 32(16):3949-57, 2011. *Co-corresponding authors •B.A. Harley, A.K. Lynn, Z. Wissner-Gross, W. Bonfield, I.V. Yannas, L.J. Gibson, Design of a multiphase osteochondral scaffold III: Fabrication of layered scaffolds with continuous interfaces, J. Biomed. Mater. Res. Part A, 92(3):1078-93, 2010. •B.A. Harley, H.-D. Kim, M.H. Zaman, I.V. Yannas, D.A. Lauffenburger, L.J. Gibson, Micro-architecture of three-dimensional scaffolds influences cell migration behavior via junction interactions, Biophys. J., 95(8):4013-24, 2008. •B.A. Harley, J.H. Leung, E. Silva, L.J. Gibson, Mechanical characterization of collagen-glycosaminoglycan scaffolds, Acta Biomater., 3(4):463-474, 2007. •F.J. OBrien, B.A. Harley, I.V. Yannas, L.J. Gibson, The effect of pore size and structure on cell adhesion in collagen-GAG scaffolds, Biomaterials, 26(4):433-441, 2005.