Bottle, Steven - Queensland University of Technology - Nanotechnology and molecular science discipline

研究领域

Research areas Detecting Free Radicals and Reactive Oxygen Species Using Fluorescence. The use of novel antioxidants to limit oxidative stress in Friedrich’s Ataxia and Ataxia Telangiectasia. Detecting cellular oxidative stress using Flow Cytometry and Confocal Microscopy. Design and synthesis of new profluorescent additives for materials protection and lifetime prediction. The group has developed world-leading expertise in the synthesis and application of nitroxide free radicals which has led to the preparation of novel antioxidant molecules of therapeutic value. These drug candidates have application in diseases such as Ataxia Telangiectasia and Friedrich’s Ataxia as well as hypertension, inflammation and heart disease. The group has also developed considerable expertise in the use of fluorescence to detect levels of oxidative stress in biological systems, as well as monitor the degradation of materials through environmental exposure. Of particular interest has been the important discovery that fluorescence can be used to monitor free radical degradation in polymers and thereby predict a material’s end of application lifetime. During 2007 the Bottle group began a collaboration with scientists and engineers from the Department of Defense to develop smart materials with application in the aeronautical industry, particularly the Joint Strike Fighter program.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Zavahir, Sifani, Xiao, Qi, Sarina, Sarina, Zhao, Jian, Bottle, Steven, Wellard, Mark Norman, et al. (2016) Selective oxidation of aliphatic alcohols using molecular oxygen at ambient temperature : Mixed-valence vanadium oxide photocatalysts. ACS Catalysis, 6, pp. 3580-3588. Hedayat, Farzaneh, Stevanovic, Svetlana, Milic, Andelija, Miljevic, Branka, Nabi, Md Nurun, Zare, Ali, et al. (2016) Influence of oxygen content of the certain types of biodiesels on particulate oxidative potential. Science of the Total Environment, 545–546, pp. 381-388. Lussini, Vanessa C., Blinco, James P., Fairfull-Smith, Kathryn E., & Bottle, Steven E. (2015) Polyaromatic profluorescent nitroxide probes with enhanced photostability. Chemistry - A European Journal, 21(50), pp. 18258-18268. Vaughan, Annalicia, Stevanovic, Svetlana, Morrison, Leanne E., Pourkhesalian, Ali M., Rahman, M. Mustafiz, Zare, Ali, et al. (2015) Removal of organic content from diesel exhaust particles alters cellular responses of primary human bronchial epithelial cells cultured at an air-liquid interface. Journal of Environmental & Analytical Toxicology, 5(5), pp. 100316-1. Simpson, Emily M., Ristovski, Zoran D., Bottle, Steven E., Fairfull-Smith, Kathryn E., & Blinco, James P. (2015) Modular design of profluorescent polymer sensors. Polymer Chemistry, 6(15), pp. 2962-2969. Xiao, Qi, Liu, Zhe, Bo, Arixin, Zavahir, Sifani, Sarina, Sarina, Bottle, Steven, et al. (2015) Catalytic transformation of aliphatic alcohols to corresponding esters in O2 under neutral conditions using visible-light irradiation. Journal of the American Chemical Society, 137(5), pp. 1956-1966. Morris, Jason, Telitel, Sofia, Fairfull-Smith, Kathryn E., Bottle, Steven E., Lalevee, Jacques, Clement, Jean-Louis, et al. (2015) Novel polymer synthesis methodologies using combination of thermally and photochemically-induced nitroxide mediated polymerisation. Polymer Chemistry, 6, pp. 754-763. Lederhose, Paul, Haworth, Naomi L., Thomas, Komba, Bottle, Steven E., Coote, Michelle L., Barner-Kowollik, Christopher, et al. (2015) Design of redox/radical sensing molecules via Nitrile Imine-Mediated Tetrazole-ene Cycloaddition (NITEC). Journal Of Organic Chemistry, 80(16), pp. 8009-8017.