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个人简介

程炜,博士,复旦大学类脑智能科学与技术研究院研究员,博士生导师,老年脑健康智能科学中心主任,复旦大学附属华山医院双聘教授。2016年获复旦大学应用数学博士学位,2018年加入复旦类脑研究院担任青年研究员,2022年破格为研究员。研究领域为发展影像遗传大数据统计方法及其在神经精神疾病中的应用研究,旨在通过影像遗传大数据揭示疾病病理机制及预测疾病进展,实现临床早期诊断与精准治疗。入选国家级青年人才、上海市启明星、上海市扬帆等人才计划,主持国自然面上、上海自然基金等项目。以通讯或第一作者(含共同)身份在相关领域发表论文40余篇(中科院一区30篇),包括脑疾病领域旗舰期刊JAMA Psychiatry、Molecular Psychiatry (四篇)、Brain (三篇)以及综合性旗舰期刊Nature Aging、Nature Communications、Nature Mental Health (四篇)等。三篇入选ESI Top 1%高被引论文,三篇入选期刊封面论文,五篇入选编辑推荐论文。研究成果被Brain、Nature Mental Health等期刊以专门评论文章正面评价,并成功应用于抑郁症的临床治疗。Google学术引用3300多次,H-index = 28。目前担任Journal of Neuroscience Methods编委、英国华威大学荣誉研究员以及Nature Human Behaviour,Biological Psychiatry等多个期刊审稿人。

研究领域

生物医学大数据 多模态数据分析 脑健康与脑疾病

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

(*) C Fei, Z Li, J Ning,…,W Cheng, J Yu. Exome sequencing identifies genes associated with sleep-related traits. Nature Human Behavior (2024). [PDF] (*) SD, Chen, J You, W Zhang,…, W Cheng, J Yu. The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders. Nature Human Behavior (2024). [PDF] (*) B, Zhang, ET Rolls, X Wang,…, W Cheng, J Feng. Roles of the medial and lateral orbitofrontal cortex in major depression and its treatment. Molecular Psychiatry (2024). [PDF] (*) Z Li, Q Ma, Y Deng,…, J Feng, W Cheng. (2024). Irritable Bowel Syndrome is Associated with Brain Health by Neuroimaging, Behavioral, Biochemical, and Genetic Analyses. Biological psychiatry, (2024) S0006-3223(24)00027-1. [PDF] (*) J You, Y Guo, Y Zhang, …, J Feng, W Cheng, J Yu. Plasma proteomic profiles predict individual future health risk. Nature Communications, 14, 7817 [2023]. [PDF] (*) YJ Ge, BS Wu, Y Zhang, …, W Cheng, J Yu. Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits. Nature Human Behavior, [2023]. [PDF] (*) D Chen, X Wang, V Voon, …, TY Jia, W Cheng, J Feng. Neurophysiological stratification of major depressive disorder by distinct trajectories. Nature Mental Health, 1, 863–875 [2023]. [PDF] (*) BS Wu, YR Zhang, Y Liu, …, W Cheng, J Yu. Polygenic Liability to Alzheimer’s Disease Is Associated with a Wide Range of Chronic Diseases: A Cohort Study of 312,305 Participants. Journal of Alzheimer’s Disease, 91(1):437-447 [2023]. [PDF] (*) YJ Zhao, L Yang, BJ Sahakian, …, J Yu, J Feng, W Cheng. The brain structure, immunometabolic and genetic mechanisms underlying the association between lifestyle and depression. Nature Mental Health, [2023]. [PDF] (*) YR Zhang, YT Deng, YZ Li, …, W Cheng, J Yu. Personality traits and brain health: a large prospective cohort study. Nature Mental Health, [2023]. [PDF] (*) Y Jiang, J Wang, E Zhou, L Palaniyappan, …, W Cheng, J Feng, the ZIB Consortium. Neuroimaging biomarkers define neurophysiological subtypes with distinct trajectories in schizophrenia. Nature Mental Health, [2023], 186–199. [PDF] (*) C Shen, ET Rolls, ST Xiang, C Langley, BJ Sahakian, W Cheng, J Feng. Brain and molecular mechanisms underlying the nonlinear association between close friendships, mental health, and cognition in children. eLife, [2023], 12:e84072. [PDF] (*) C Zhou, L Wang, W Cheng, …, J Feng, M Zhang. Two distinct trajectories of clinical and neurodegeneration events in Parkinson’s disease. npj Parkinson’s Disease, [2023], 9, 111. [PDF] (*) YJ Sun, BJ Sahakian, C Langley, …, W Cheng, J Feng. Early-initiated childhood reading for pleasure: associations with better cognitive performance, mental well-being and brain structure in young adolescence. Psychological Medicine, [2023], 1-15. [PDF] (*) J You, Y Guo, J Kang, H Wang, M Yang, J Feng, J Yu, W Cheng. Development of machine learning-based models to predict 10-year risk of cardiovascular disease: a prospective cohort study. Stroke and Vascular Neurology, [2023]. [PDF] (*) L Wang, C Zhou, W Zhang, M Zhang, W Cheng, J Feng. Association of Cortical and Subcortical Microstructure With Clinical Progression and Fluid Biomarkers in Patients With Parkinson Disease. Neurology, [2023], 101(3), e300-e310. [PDF] (*) W Zhang, H Wang, K Kuo, L Wang, Y Li, J Yu, J Feng, W Cheng. Contribution of Alzheimer’s disease pathology to biological and clinical progression: A longitudinal study across two cohorts. Alzheimer’s Dementia, [2023], 1-11. [PDF] (*) YN Ou, BS Wu, YJ Ge, Y Zhang, YC Jiang, K Kuo, …, W Cheng, J Yu. The genetic architecture of human amygdala volumes and their overlap with common brain disorders. Translational Psychiatry, [2023], 1-12. [PDF] (*) Y Li, BJ Sahakian, J Kang, C Langley, W Zhang, …, W Cheng, JF Feng. The brain structure and genetic mechanisms underlying the nonlinear association between sleep duration, cognition and mental health. Nature Aging, [2022], 2(5), 425-437. [PDF] (*) S Huang, Y Li, Y Zhang, Y Huang, …, W Cheng, JT Yu. Sleep, physical activity, sedentary behavior, and risk of incident dementia: a prospective cohort study of 431,924 UK Biobank participants. Molecular Psychiatry, [2022]. [PDF] (*) Z Wan, ET Rolls, J Feng, W Cheng. Brain functional connectivities that mediate the association between childhood traumatic events, and adult mental health and cognition. EBioMedicine, [2022], 79, 104002. [PDF] (*) J You, YR Zhang, HF Wang, M Yang, JF Feng, JT Yu, W Cheng. Development of a novel dementia risk prediction model in the general population: A large, longitudinal, population-based machine-learning study. eClinicalMedicine, [2022], 53, 101665. [PDF] (*) L Yang, YT Deng, Y Leng, YN Ou, YZ Li, …, W Cheng, JT Yu. Depression, Depression Treatments, and Risk of Incident Dementia: A Prospective Cohort Study of 354,313 Participants. Biological Psychiatry, [2022]. [PDF] (*) J Du, ET Rolls, W Gong, M Cao, D Vatansever, J Zhang, J Kang, W Cheng, JF Feng. Association between parental age, brain structure, and behavioral and cognitive problems in children. Molecular Psychiatry, [2022], 27(2), 967-975. [PDF] (*) Q Ma, H Wang, ET Rolls, S Xiang, J Li, Y Li, Q Zhou, W Cheng, F Li. Lower gestational age is associated with lower cortical volume and cognitive and educational performance in adolescence. BMC Medicine , [2022]. [PDF] (*) L Wang, P Wu, P Brown, W Zhang, F Liu, et al. Association of Structural Measurements of Brain Reserve With Motor Progression in Patients With Parkinson Disease. Neurology, [2022]. [PDF] (*) HF Wang, W Zhang, ET Rolls, Y Li, L Wang, …, W Cheng. Hearing impairment is associated with cognitive decline, brain atrophy and tau pathology. EBioMedicine, [2022]. [PDF] (*) L Wang, C Zhou, W Cheng, ET Rolls, P Huang, et al. Dopamine depletion and subcortical dysfunction disrupt cortical synchronization and metastability affecting cognitive function in Parkinson’s disease. Human Brain Mapping, [2022], 43(5), 1598-1610. [PDF] (*) Q Ma, ET Rolls, CC Huang, W Cheng, J Feng. Extensive cortical functional connectivity of the human hippocampal memory system. Cortex, [2022], 147, 83-101. [PDF] (*) YT Deng, YZ Li, SY Huang, YN Ou, W Zhang, …, W Cheng, JT Yu. Association of life course adiposity with risk of incident dementia: a prospective cohort study of 322,336 participants. Molecular Psychiatry, [2022]. [PDF] (*) A Yang, ET Rolls, G Dong, J Du, Y Li, J Feng, W Cheng, XM Zhao. Longer screen time utilization is associated with the polygenic risk for Attention-deficit/hyperactivity disorder with mediation by brain white matter microstructure. EBioMedicine, [2022], 80, 104039. [PDF] (*) L Wang, W Zhang, F Liu, C Mao, CF Liu, W Cheng, J Feng. Association of Cerebrospinal Fluid Neurofilament Heavy Protein Levels With Clinical Progression in Patients With Parkinson Disease. JAMA Network Open, [2022], 5(7), e2223821-e2223821. [PDF] (*) W Gong, ET Rolls, J Du, J Feng, W Cheng. Brain structure is linked to the association between family environment and behavioral problems in children in the ABCD study. Nature Communications, [2021], 12 (1):1-10. [PDF] (#) L He, D Wei, F Yang, J Zhang, W Cheng, J Feng, W Yang, K Zhuang, et al. Functional connectome prediction of anxiety related to the COVID-19 pandemic. American Journal of Psychiatry, [2021], 178 (6), 530-540. [PDF] (#, *) LB Wang, W Cheng, ET Rolls, FL Dai, et al. Association of specific biotypes in patients with Parkinson disease and disease progression. Neurology, [2020]. [PDF] (*) H Wang, ET Rolls, XJ Du, … W Cheng, JF Feng. Severe nausea and vomiting in pregnancy: psychiatric and cognitive problems, and brain structure in children. BMC Medicine, [2020]. [PDF] (#, *) W Cheng, E Rolls, W Gong, J Du, J Zhang, XY Zhang, F Li, J Feng. Sleep duration, brain structure, and psychiatric and cognitive problems in children. Molecular Psychiatry, [2020]. [PDF] (#, *) J Du, ET Rolls, W Cheng, Y Li, W Gong, J Qiu, J Feng. Functional connectivity of the orbitofrontal cortex, anterior cingulate cortex, and inferior frontal gyrus in humans. Cortex, [2020]: 123, 185-199. [PDF] (#) ET Rolls, Y Zhou, W Cheng, M Gilson, G Deco, J Feng. Effective connectivity in autism. Autism Research, [2020]: 13 (1), 32-44. [PDF] (#, *) ET Rolls, W Cheng, J Du, D Wei, J Qiu, D Dai, Q Zhou, P Xie, J Feng. Functional connectivity of the right inferior frontal gyrus and orbitofrontal cortex in depression. Social cognitive and affective neuroscience, [2019]. [PDF] (#, *) ET Rolls, W Cheng, M Gilson, W Gong, G Deco, C Yo, et al. Beyond the disconnectivity hypothesis of schizophrenia. Cerebral Cortex, [2019], bhz161. [PDF] Z Liu, ET Rolls, Z Liu, K Zhang, M Yang, J Du, W Gong, W Cheng, F Dai, et al. Brain annotation toolbox: exploring the functional and genetic associations of neuroimaging results. Bioinformatics, [2019]. [PDF] W Cheng, ET Rolls, TW Robbins, W Gong, Z Liu, et al. Decreased brain connectivity in smoking contrasts with increased connectivity in drinking. eLife, [2019]. (eLife Digest) [PDF] W Cheng, ET Rolls, J Qiu, D Yang, H Ruan, D Wei, L Zhao, et al. Functional connectivity of the precuneus in unmedicated patients with depression. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, [2018]: 1040-1049. [PDF] (#, *) ET Rolls, W Cheng, W Gong, J Qiu, C Zhou, J Zhang, et al. Functional connectivity of the anterior cingulate cortex in depression and in health. Cerebral Cortex, [2018]: 14. [PDF] W Cheng, ET Rolls, H Ruan, J Feng, et al. Functional connectivities in the brain that mediate the association between depressive problems and sleep quality. JAMA Psychiatry, [2018], 75(10): 1052-1061. [PDF] Z Liu, J Zhang, K Zhang, J Zhang, X Li, W Cheng, M Li, L Zhao, et al. Distinguishable brain networks relate disease susceptibility to symptom expression in schizophrenia. Human Brain Mapping, [2018], 39(9): 3503-3515. [PDF] W Gong, L Wan, W Lu, L Ma, F Cheng, W Cheng, S Gruenewald, J Feng. Statistical testing and power analysis for brain-wide association study. Medical Image Analysis,[2018], 47: 15-30. [PDF] W Cheng, ET Rolls, J Qiu, X Xie, W Lyu, Y Li, CC Huang, AC Yang, et al. Functional connectivity of the human amygdala in health and in depression. Social Cognitive and Affective Neuroscience, [2018], 13(6): 557-568. [PDF] W Cheng, ET Rolls, J Qiu, X Xie, D Wei, CC Huang, AC Yang, SJ Tsai, et al. Increased functional connectivity of the posterior cingulate cortex with the lateral orbitofrontal cortex in depression. Translational Psychiatry, [2018], 8(1): 90. [PDF] (#) ET Rolls, W Cheng, M Gilson, J Qiu, Z Hu, H Ruan, Y Li, CC Huang, et al. Effective connectivity in depression. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, [2018], 3(2): 187-197. (Cover Paper) [PDF] 2017 T Li, Q Wang, J Zhang, ET Rolls, W Yang, L Palaniyappan, L Zhang, W Cheng, et al. Brain-wide analysis of functional connectivity in first-episode and chronic stages of schizophrenia. Schizophrenia Bulletin, [2017], 43(2): 436-448. [PDF] W Cheng, ET Rolls, J Zhang, W Sheng, L Ma, L Wan, Q Luo, J Feng. Functional connectivity decreases in autism in emotion, self, and face circuits identified by Knowledge-based Enrichment Analysis. NeuroImage, [2017], 148: 169-178. [PDF] W Cheng, ET Rolls, J Qiu, W Liu, Y Tang, CC Huang, XF Wang, J Zhang,, et al. Medial reward and lateral non-reward orbitofrontal cortex circuits change in opposite directions in depression. Brain, [2016], 139(12): 3296-3309. [PDF] (#) J Zhang, W Cheng, Z Liu, K Zhang, X Lei, Y Yao, B Becker, Y Liu,, et al. Neural, electrophysiological and anatomical basis of brain-network variability and its characteristic changes in mental disorders. Brain, [2016], 139(8): 2307-2321. (Cover Paper) [PDF] (#) Q Wang, W Cheng, M Li, H Ren, X Hu, W Deng, X Ma, L Zhao, et al. The CHRM3 gene is implicated in abnormal thalamo-orbital frontal cortex functional connectivity in first-episode treatment-naive patients with schizophrenia. Psychological Medicine, [2016], 46(7): 1523-1534. [PDF] H Cui, J Zhang, Y Liu, Q Li, H Li, L Zhang, Q Hu, W Cheng, et al. Differential alterations of resting‐state functional connectivity in generalized anxiety disorder and panic disorder. Human Brain Mapping, [2016], 37(4): 1459-1473. [PDF] W Cheng, ET Rolls, H Gu, J Zhang, J Feng. Autism: reduced connectivity between cortical areas involved in face expression, theory of mind, and the sense of self. Brain, [2015], 138(5): 1382-1393. (Editor’s Choice) [PDF] W Cheng, L Palaniyappan, M Li, KM Kendrick, J Zhang, Q Luo, Z Liu, et al. Voxel-based, brain-wide association study of aberrant functional connectivity in schizophrenia implicates thalamocortical circuitry. npj Schizophrenia, [2015], 1: 15016. (Editor’s Choice) [PDF] (#) Q Luo, W Lu, W Cheng, PA Valdes-Sosa, X Wen, M Ding, J Feng. Spatio-temporal Granger causality: A new framework. NeuroImage, [2013], 79: 241-263. [PDF] W Cheng, X Ji, J Zhang, J Feng. Individual classification of ADHD patients by integrating multiscale neuroimaging markers and advanced pattern recognition techniques. Frontiers in Systems Neuroscience, [2012] 6, 58. [PDF] (#) J Zhang, W Cheng, ZG Wang, ZQ Zhang, WL Lu, GM Lu, J Feng. Pattern classification of large-scale functional brain networks: identification of informative neuroimaging markers for epilepsy. PloS one, [2012] 7 (5), e36733. [PDF]

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