个人简介

Barbara J Sahakian is Professor of Clinical Neuropsychology at the University of Cambridge Department of Psychiatry and Behavioural and Clinical Neuroscience Institute. Sahakian is also an Honorary Clinical Psychologist at Addenbrooke’s Hospital. She is a Fellow of the British Academy and the Academy of Medical Sciences. She was a Member of the International Expert Jury for the 2017 Else Kröner-Fresenius-Stiftung Prize. She is a Past President of the British Association for Psychopharmacology and of the International Neuroethics Society. Sahakian has an international reputation in the fields of psychopharmacology, neuropsychology, neuropsychiatry, neuroimaging and neuroethics. She is best known for her work on ‘hot’ and ‘cold’ cognitive deficits in depression and early detection and early treatment with cholinesterase inhibitors in Alzheimer’s disease. She has over 400 publications in scientific journals and a Hirsch (h) index of 109. Sahakian co-invented the neuropsychological CANTAB and EMOTICOM tests and the Cambridge University PEAK Memory Training: Wizard game. Sahakian has contributed to Neuroscience and Mental Health Policy, including the UK Government Foresight Project on Mental Capital and Wellbeing (Beddington et al., 2008, Nature), the Strategy for Mental Health for the Medical Research Council (Sahakian et al., 2010, The Lancet) and the Grand Challenges in Global Mental Health (Collins et al., 2011, Nature). She is on the Committee for the Strategy for Neuroscience and Mental Health for the Department of Health. In March 2017, she participated in the Global Council on Brain Health meeting in Washington, DC. She has spoken at the World Economic Forum, Davos, 2014 and is a member of the WEF on the Future of Neurotechnologies and Brain Science. She is also on the Clinical Advisory Board of the Human Brain Project. She is co-author of Bad Moves (Oxford University Press, 2013) and Sex, Lies, & Brain Scans (Oxford University Press, 2017). She has also co-edited The Oxford Handbook of Neuroethics.

研究领域

Clinical Neuropsychology,Psychopharmacology, Neuropsychiatry

My research is aimed at understanding the neural basis of cognitive, emotional and behavioural dysfunction in order to develop more effective pharmacological and psychological treatments. The focus of my lab is on early detection, differential diagnosis and proof of concept studies using cognitive enhancing drugs. This research utilises neuropsychological tests, such as the CANTAB tests, which I co-invented and a focus remains on the development of novel tests. Current study participants include healthy volunteers and patient groups with brain injury, Alzheimer?s disease, attention deficit hyperactivity disorder (ADHD), obsessive compulsive disorder, substance abuse, depression and mania. Techniques used include psychopharmacological, neuropsychological, neuroimaging (fMRI and PET) and genetic ones. Results from recent studies of ecstasy use and cognitive enhancement using methylphenidate, modafinil and atomoxetine have led to an interest in pharmacogenomics and neuroethics.

近期论文

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Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making. DOI: http://doi.org/10.1038/s41386-023-01762-6 Journal: Neuropsychopharmacology E-pub date: 1 Feb 2024 Authors: Q Luo, JW Kanen, A Bari, N Skandali, C Langley, GM Knudsen, J Alsi?, BU Phillips, BJ Sahakian, RN Cardinal, TW Robbins Perseveration and shifting in obsessive–compulsive disorder as a function of uncertainty, punishment, and serotonergic medication DOI: http://doi.org/10.1016/j.bpsgos.2023.06.004 Journal: Biol Psychiatry Glob Open Sci E-pub date: 1 Jan 2024 Authors: T Robbins Corrigendum to “Altered centromedial amygdala functional connectivity in adults is associated with childhood emotional abuse and predicts levels of depression and anxiety” [J. Affect. Disord. 303 (2022) 148-154]. DOI: http://doi.org/10.1016/j.jad.2023.09.032 Journal: J Affect Disord E-pub date: 15 Dec 2023 Authors: L Luo, T Yang, X Zheng, X Zhang, S Gao, Y Li, EA Stamatakis, B Sahakian, B Becker, Q Lin, KM Kendrick Depressive symptoms following traumatic brain injury are associated with resting-state functional connectivity. DOI: http://doi.org/10.1017/S0033291721004724 Journal: Psychol Med E-pub date: 1 Apr 2023 Authors: L Luo, C Langley, L Moreno-Lopez, K Kendrick, DK Menon, EA Stamatakis, BJ Sahakian Chronic escitalopram in healthy volunteers has specific effects on reinforcement sensitivity: a double-blind, placebo-controlled semi-randomised study. DOI: http://doi.org/10.1038/s41386-022-01523-x Journal: Neuropsychopharmacology E-pub date: 1 Mar 2023 Authors: C Langley, S Armand, Q Luo, G Savulich, T Segerberg, A S?ndergaard, EB Pedersen, N Svart, O Overgaard-Hansen, A Johansen, C Borgsted, RN Cardinal, TW Robbins, DS Stenb?k, GM Knudsen, BJ Sahakian Distributed harmonic patterns of structure-function dependence orchestrate human consciousness DOI: http://doi.org/10.1038/s42003-023-04474-1 Journal: Commun Biol E-pub date: 28 Jan 2023 Authors: AI Luppi, J Vohryzek, ML Kringelbach, PAM Mediano, MM Craig, R Adapa, RL Carhart-Harris, L Roseman, I Pappas, ARD Peattie, AE Manktelow, BJ Sahakian, P Finoia, GB Williams, J Allanson, JD Pickard, DK Menon, S Atasoy, EA Stamatakis Prefrontal Cortex Activation and Stopping Performance Underlie the Beneficial Effects of Atomoxetine on Response Inhibition in Healthy Volunteers and Those With Cocaine Use Disorder. DOI: http://doi.org/10.1016/j.bpsc.2021.08.010 Journal: Biol Psychiatry Cogn Neurosci Neuroimaging E-pub date: 1 Nov 2022 Authors: P Zhukovsky, S Morein-Zamir, H Ziauddeen, E Fernandez-Egea, C Meng, R Regenthal, BJ Sahakian, ET Bullmore, TW Robbins, JW Dalley, KD Ersche Altered centromedial amygdala functional connectivity in adults is associated with childhood emotional abuse and predicts levels of depression and anxiety. DOI: http://doi.org/10.1016/j.jad.2022.02.023 Journal: J Affect Disord E-pub date: 15 Apr 2022 Authors: L Luo, T Yang, X Zheng, X Zhang, S Gao, Y Li, EA Stamatakis, B Sahakian, B Becker, Q Lin, KM Kendrick Understanding the relationship between cognitive performance and function in daily life after traumatic brain injury. DOI: http://doi.org/10.1136/jnnp-2020-324492 Journal: J Neurol Neurosurg Psychiatry E-pub date: 2 Dec 2020 Authors: L Wilson, L Horton, K Kunzmann, BJ Sahakian, VF Newcombe, EA Stamatakis, N von Steinbuechel, K Cunitz, A Covic, A Maas, D Van Praag, D Menon, CENTER-TBI participants and investigators Effect of tryptophan depletion on conditioned threat memory expression: role of intolerance of uncertainty DOI: http://doi.org/10.1101/2020.04.26.062505 Journal: E-pub date: 1 Aug 2020 Authors: J Kanen, F Arntz, R Yellowlees, D Christmas, A Price, A Apergis-Schoute, B Sahakian, R Cardinal, T Robbins Distributed harmonic patterns of structure-function dependence orchestrate human consciousness DOI: http://doi.org/10.1101/2020.08.10.244459 Journal: E-pub date: 1 Aug 2020 Authors: A Luppi, J Vohryzek, M Kringelbach, PAM Mediano, M Craig, R Adapa, R Carhart-Harris, L Roseman, I Pappas, ARD Peattie, A Manktelow, B Sahakian, P Finoia, G Williams, J Allanson, J Pickard, D Menon, S Atasoy, E Stamatakis Depression following traumatic brain injury is characterised by dominant and recurring brain loops in self-referential areas DOI: http://doi.org/10.1101/2020.08.14.20175000 Journal: E-pub date: 1 Aug 2020 Authors: I Pappas, L Moreno-López, E Carroll, A Manktelow, J Outtrim, J Coles, V Newcombe, B Sahakian, D Menon, E Stamatakis Probabilistic reversal learning under acute tryptophan depletion in healthy humans: a conventional analysis. DOI: http://doi.org/10.1177/0269881120907991 Journal: J Psychopharmacol E-pub date: 1 May 2020 Authors: JW Kanen, FE Arntz, R Yellowlees, RN Cardinal, A Price, DM Christmas, BJ Sahakian, AM Apergis-Schoute, TW Robbins Dopaminergic modulation of reinforcement learning in stimulant drug addiction DOI: http://doi.org/10.1016/j.euroneuro.2019.09.191 Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY E-pub date: 1 Aug 2019 Authors: TV Lim, RN Cardinal, C Meng, GK Murray, KJ Craig, S Abbott, SS Shabbir, J Suckling, BJ Sahakian, ET Bullmore, TW Robbins, KD Ersche Noradrenergic modulation of stopping impulsivity in cocaine use disorder DOI: http://doi.org/10.1016/j.euroneuro.2018.11.317 Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY E-pub date: 1 Aug 2019 Authors: R Rodrigues, S Morein-Zamir, C Meng, H Ziauddeen, E Fernandez-Egea, R Regenthal, BJ Sahakian, ET Bullmore, TW Robbins, KD Ersche Novel Smartphone Interventions Improve Cognitive Flexibility and Obsessive-Compulsive Disorder Symptoms in Individuals with Contamination Fears. DOI: http://doi.org/10.1038/s41598-018-33142-2 Journal: Sci Rep E-pub date: 23 Oct 2018 Authors: B Jalal, A Brühl, C O'Callaghan, T Piercy, RN Cardinal, VS Ramachandran, BJ Sahakian Methylphenidate-mediated motor control network enhancement in patients with traumatic brain injury. DOI: http://doi.org/10.1080/02699052.2018.1469166 Journal: Brain Inj E-pub date: 1 Aug 2018 Authors: CL Dorer, AE Manktelow, J Allanson, BJ Sahakian, JD Pickard, A Bateman, DK Menon, EA Stamatakis Personalised treatments for traumatic brain injury: cognitive, emotional and motivational targets. DOI: http://doi.org/10.1017/S0033291718000892 Journal: Psychol Med E-pub date: 1 Jul 2018 Authors: G Savulich, DK Menon, EA Stamatakis, JD Pickard, BJ Sahakian Default Mode Network Engagement Beyond Self-Referential Internal Mentation. DOI: http://doi.org/10.1089/brain.2017.0489 Journal: Brain Connect E-pub date: 1 May 2018 Authors: D Vatansever, A Manktelow, BJ Sahakian, DK Menon, EA Stamatakis Spectral Diversity in Default Mode Network Connectivity Reflects Behavioral State. DOI: http://doi.org/10.1162/jocn_a_01213 Journal: J Cogn Neurosci E-pub date: 1 Apr 2018 Authors: MM Craig, AE Manktelow, BJ Sahakian, DK Menon, EA Stamatakis Atomoxetine effects on attentional bias to drug-related cues in cocaine dependent individuals. DOI: http://doi.org/10.1007/s00213-017-4643-4 Journal: Psychopharmacology (Berl) E-pub date: 31 Aug 2017 Authors: L Passamonti, M Luijten, H Ziauddeen, ITS Coyle-Gilchrist, T Rittman, SAE Brain, R Regenthal, IHA Franken, BJ Sahakian, ET Bullmore, TW Robbins, KD Ersche