Momot, Konstantin - Queensland University of Technology - Biomedical engineering and medical physics discipline

研究领域

Molecular dynamics of hydrated cartilage biopolymers: The aim of this project is to study molecular dynamics of hydrated collagen and proteoglycans – biopolymers forming the molecular scaffold of cartilage. The objective is to investigate the effect of aligned collagen fibres on NMR properties of tissue water, and to use that information for interpretation of cartilage MR images. NMR spectroscopy and MR microimaging of cartilage: This project involves the development of state-of-the-art techniques of cartilage microimaging: diffusion-tensor imaging, MRI mechanical-load consolidometry, and quantitative relaxation-weighted imaging. The aim is to characterise the macromolecular structure of the tissue scaffold; study its response to mechanical load and enzymatic degradation; and to identify reliable MRI signatures of early osteoarthritis. NMR and computational studies of bicontinuous cubic phases: BCPs are thermodynamically stable lipids/water systems used to model the biophysics of lipid bilayers. We use Monte Carlo simulations and NMR spectroscopy to investigate the relationship between microstructure, molecular mobility, and molecular transport properties of BCPs. The aim is to develop an in vitro permeability model of the lipid bilayer.

近期论文

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Tadimalla S, Momot K, (2014) Effect of partial H2O-D2O replacement on the anisotropy of transverse proton spin relaxation in bovine articular cartilage, PLoS One p1-19 Tourell MC, Powell SK, Momot K, (2013) Diffusion tensor of water in partially aligned fibre networks, Journal of Physics D: Applied Physics p1-11 Powell S, Momot K, (2012) Langevin dynamics modeling of the water diffusion tensor in partially aligned collagen networks, Physical Review E (Statistical, Nonlinear, and Soft Matter Physics) p1-13 Rathnayaka Mudiyanselage K, Momot K, Noser H, Volp A, Schuetz M, Sahama TR, Schmutz B, (2012) Quantification of the accuracy of MRI generated 3D models of long bones compared to CT generated 3D models, Medical Engineering and Physics p357-363 Momot K, Takegoshi K, (2012) Sensitivity of the NMR density matrix to pulse sequence parameters: A simplified analytic approach, Journal of Magnetic Resonance p57-68 De Visser SK, Bowden JC, Wentrup-Byrne E, Rintoul L, Bostrom T, Pope JM, Momot K, (2008) Anisotropy of collagen fibre alignment in bovine cartilage: comparison of polarised light microscopy and spatially resolved diffusion-tensor measurements1, Osteoarthritis and Cartilage p689-697 Momot K, Kuchel PW, (2006) PFG NMR Diffusion Experiments for Complex Systems, Concepts in Magnetic Resonance. Part A p249-269 Momot K, Kuchel PW, (2004) Convection-compensating PGSE experiment incorporating excitation-sculpting water suppression (CONVEX), Journal of Magnetic Resonance p92-101 Momot K, Kuchel PW, Chapman BE, Deo P, Whittaker D, (2003) NMR study of the association of propofol with nonionic surfactants, Langmuir: the ACS journal of surfaces and colloids p2088-2095 Momot K, Kuchel PW, (2003) Pulsed field gradient nuclear magnetic resonance as a tool for studying drug delivery systems, Concepts in Magnetic Resonance. Part A p51-64