Langton, Christian - Queensland University of Technology - Biomedical engineering and medical physics discipline

个人简介

Professor Langton developed the technique of broadband ultrasonic attenuation (BUA) for the assessment of osteoporosis, being awarded a DSc in 2007 for his extensive research contributions to the science, technology and clinical utility. He has over 3500 publication citations with a current h-index of 29. BUA was recognised in 2006 (EurekaUK) by Universities UK as one of the top “100 discoveries and developments in UK Universities that have changed the world” over the past 50 years, covering the whole spectrum from the arts and humanities to science and technology. In 2008, the UK’s Department of Health also recognised Professor Langton’s contributions in a publication highlighting eleven projects that have contributed to ‘60 years of NHS research benefiting patients’. Professor Langton previously served as Sub-Dean for Research and Reach-Out within University of Hull’s Postgraduate Medical Institute, and Director of R&D Performance within Hull & East Yorkshire Hospitals NHS Trust. He was appointed Professor of Medical Physics at Queensland University of Technology (QUT) in February 2008 and Head of Physics in 2010. In January 2012 he was appointed Assistant Dean (Research) for the new Science & Engineering Faculty (SEF).

研究领域

Ultrasound Transit Time Spectroscopy (UTTS): Characterisation of Complex Porous Composites Langton has recently proposed that the primary attenuation mechanism associated with ultrasound characterisation of complex porous composites such as cancellous bone is phase interference due to variations in propagation transit time. Considering an array of parallel ‘sonic rays’, a transit time spectrum may be experimentally derived by deconvolution of ultrasound signals with, and without, the test sample; quantitative analysis providing information on its volume fraction and structure. It is envisaged that UTTS has the potential to provide for the first time using ultrasound, a WHO T-Score clinical diagnosis of osteoporosis. Further research is developing a Unified Model for all potential signal inputs and composite propagation media, with potential applications including characterisation of visco-elastic tissues and improvement of conventional clinical ultrasound imaging performance. Ultrasound-Guided Robotic Intervention: Real-Time Tracking of Tumour Movement DuringRadiotherapy We have created a ‘proof of concept’ system consisting of two robotic arms, one to facilitate user-controlled movement of a virtual tumour (gel dosimeter); the other to manipulate a 3D ultrasound transducer. It is envisaged that tumour tracking will facilitate quantification of dosimetric consequences associated with movement during radiation therapy delivery and inform modifications to the prescribed dose of subsequent fractions. Quantitative 3D Imaging: Ultrasound Computed Tomography System A ‘proof of concept’ system has been developed utilising a robotic arm to facilitate rotation and translation of two aligned phased-array transducers, each controlled by a separate Olympus Omniscan instrumentation unit to facilitate maximum field size. Clinical applications considered to date include gel dosimeters for radiation therapy and quantitative imaging of long bones. A clinical scanner is envisaged with clinical applications including paediatric subjects, complex trauma, and fatigue fracture prediction in elite athletes and armed forces personnel. Quantitative 3D Imaging: Flat-Bed Scanner By translating a phased-array transducer under motor-control, a quantitative 3D mapping may be created. Clinical applications considered to date include identification of breast lesions and skeletal assessment of very-low birthweight premature neonates. Quantitative 3D Imaging: Free-Hand Bone Imaging By combining a series of ‘free-hand’ images of known orientation, we may create an accurate rendering of a bone surface; a clinical example being bespoke fracture plates, achieved by scanning a subject’s contra-lateral limb. We are also developing a technique to image bone implants such as screws and plates that incorporates a semi-automated spatial correction associated with the velocity disparity between soft-tissues and cortical bone. Quantitative 3D Imaging: Tropical Healthcare SmartPhone Scanner Noting the geographical Tropics encompasses most of the Developing World, a low-cost, battery-powered, cordless, hand-held scanner is being developed utilising a SmartPhone’s screen and inclinometers. Combined Diagnostic-Therapeutic Transducer The potential to develop an ultrasound transducer that delivers both diagnostic (short low-intensity) and therapeutic (long high-intensity) ultrasound signals is being investigated. Such a system would have significant potential to be combined with enhanced contrast / drug delivery micro-capsules.

近期论文

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Poole C, Cornelius I, Trapp J, Langton C, (2012) A CAD interface for GEANT4, Australasian Physical and Engineering Sciences in Medicine p329-334 Poole C, Cornelius I, Trapp J, Langton C, (2012) Fast tessellated solid navigation in GEANT4, IEEE Transactions on Nuclear Science p1695-1701 Njeh CF, Langton CM, (2011) The adoption of new technology in radiation oncology should rely on evidence-based medicine, Medical Physics p2825-2828 Njeh CF, Saunders MW, Langton CM, (2012) Accelerated partial breast irradiation using external beam conformal radiation therapy: A review, Critical Reviews in Oncology / Hematology p1-20 Langton CM, (2011) The 25th anniversary of BUA for the assessment of osteoporosis: time for a new paradigm?, Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine p113-125 Flegg MB, Poole CM, Whittaker AK, Keen I, Langton CM, (2010) Rayleigh theory of ultrasound scattering applied to liquid-filled contrast nanoparticles, Physics in Medicine and Biology p3061-3076 Langton CM, Pisharody S, Keyak J, (2009) Comparison of 3D finite element analysis derived stiffness and BMD to determine the failure load of the excised proximal femur, Medical Engineering & Physics p668-672 Langton CM, Pisharody S, Keyak J, (2009) Generation of a 3D proximal femur shape from a single projection 2D radiographic image, Osteoporosis International p455-461 Liney GP, Bernard CP, Manton DJ, Turnbull LW, Langton CM, (2007) Age, gender, and skeletal variation in bone marrow composition: A preliminary study at 3.0Tesla, Journal of Magnetic Resonance Imaging p787-793 Bernard CP, Liney GP, Manton DJ, Turnbull LW, Langton CM, (2008) Comparison of fat quantification methods: A phantom study at 3.0T, Journal of Magnetic Resonance Imaging p192-197