Weible, Michael - Griffith University - School of Natural Sciences

研究领域

Neurogenesis (the birth of neurons) is maintained in discrete neurogenic areas of the adult mammalian brain. One such area is the subventricular zone (SVZ) linings of the lateral ventricles in the neocortex. This highly vascularized niche plays host to a persistent population of pluripotent radial glial-like adult neural stem cells (aNSC) capable of giving rise to the three main lineages: neurons, oligodendrocytes and astrocytes. While the underlying mechanisms of SVZ neurogenesis have yet to be elucidated, a limited number of investigations have shown calcium signalling to play a functional role in aNSC cellular physiology. Our research group aims to uncover the molecular mechanisms involved in regulation of intracellular calcium oscillations [Ca2+]i and to determine what their regulatory role is in the maintenance of the adult neurogenic niche. Stem cells from the adult nervous system; Neurogenesis and regeneration of the nervous system; Repair of the nervous system via cell transplantation therapies; Calcium signalling

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Mansour H, McColm JR, Cole L, Weible M 2nd, Korlimbinis A, Chan-Ling T: Connexin 30 expression and frequency of connexin heterogeneity in astrocyte gap junction plaques increase with age in the rat retina. PLoS One. 2013;8(3), Epub 2013 Mar 14. Chan-Ling T, Chu Y, Baxter L, Weible MW 2nd and Hughes S: In vivo characterization of astrocyte precursor cells (APCs) and astrocytes in developing rat retina; differentiation, proliferation and apoptosis. Glia. 2009 Jan 1;57(1):39-53. Mansour H, Chamberlain CG, Weible MW 2nd, Hughes S, Ch Y and Chan-Ling T: Aging-related changes in astrocytes in the rat retina: Imbalance between cell proliferation and cell death reduces astrocyte availability. Aging Cell. 2008 Aug;7(4):526-40. Weible MW 2nd and Chan-Ling, T: Phenotypic characterization of neural stem cells from human fetal spinal cord: Synergistic effect of LIF and BMP4 to generate astrocytes (plus Cover Photo). Glia 2007 Aug 15;55(11): 1156-68 Weible MW 2nd and Hendry IA: What is the importance of Multivesicular Bodies in retrograde axonal transport in vivo. J Neurobiology 2004 Feb;58(2):230-43.