Crane, Denis - Griffith University - School of Natural Sciences

研究领域

My research interests are in the general field of molecular cell biology. My main research program has been in understanding the biogenesis and function of peroxisomes, and the application of these findings to the genetic and molecular basis of the human peroxisomal disorders, such as Zellweger syndrome. My research has recently expanded into investigations of the molecular basis of Zellweger syndrome neuropathology using mouse models of this disease, and of other neuropathological diseases such as Hereditary Spastic Paraplegia.

近期论文

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Yakunin E, Moser A, Loeb V, Reisch AS, Faust P, Crane DI, Baes M and Sharon R. (2010) α-Synuclein Abnormalities in Mouse Models of Peroxisome Biogenesis Disorders: Implications for the Involvement of Peroxisomes in Parkinson’s Disease. J. Neurosci. Res 88, 866-876. Mueller CC, Nguyen TH, Ahlemeyer B, Meshram M, Santrampurwala N, Cao S, Sharp P, Fietz PB, Baumgart-Vogt E. and Crane DI. (2011) PEX13-deficiency in mouse brain as a model of Zellweger syndrome: abnormal cerebellum formation, reactive gliosis and oxidative stress. Disease Models Mech. 4, 104-119. Das I, Png CW, Oancea I, Hasnain SZ, Lourie R, Proctor M, Eri RD, Sheng Y, Crane DI, Florin TH, McGuckin MA (2013) Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins. J Exp Med. 210:1201-1216.