Brownlie, Jeremy - Griffith University - School of Natural Sciences

研究领域

Animals are host to a wide and diverse range of bacteria that can impact upon, or are required to maintain proper health. An emerging area of research are the impacts that bacteria have on animal behaviour, which for many years have focused exclusively on genetics and the surrounding environment. By combining molecular, and whole organismal techniques my research group seeks to: Identify which bacteria influence complex behaviours in sleep, learning and memory. Determine how are such changes achieved at a gene, biochemical and physiological scale. Insects are commonly infected by a bacterial endosymbiont called Wolbachia, which has been shown to disrupt the replication of viruses within insects. How Wolbachia disrupts viral replication is unclear. My research group seeks to answer: How Wolbachia protect insect hosts against other pathogens such as viruses and fungi? Can Wolbachia be developed as a biological control agent to control the spread of insect transmitted viruses? Temporary medical implants, such as intravenous needles and catheters, that remain within a patient for extended periods of time are prone to bacterial colonization and biofilm formation. When established these bacterial communities are highly resistant to antibiotic treatment. There is a need to establish rapid quantitate methods that can identify important bacterial species. In collaboration with the School of Nursing and local hospitals in Brisbane, we seek to: Develop novel quantitative diagnostic tools to monitor the causal agents of infections within a clinical setting. Animals are host to a wide and diverse range of bacteria that can impact upon, or are required to maintain proper health. An emerging area of research are the impacts that bacteria have on animal behaviour, which for many years have focused exclusively on genetics and the surrounding environment. By combining molecular, and whole organismal techniques my research group seeks to: Identify which bacteria influence complex behaviours in sleep, learning and memory. Determine how are such changes achieved at a gene, biochemical and physiological scale. Insects are commonly infected by a bacterial endosymbiont called Wolbachia, which has been shown to disrupt the replication of viruses within insects. How Wolbachia disrupts viral replication is unclear. My research group seeks to answer: How Wolbachia protect insect hosts against other pathogens such as viruses and fungi? Can Wolbachia be developed as a biological control agent to control the spread of insect transmitted viruses? Temporary medical implants, such as intravenous needles and catheters, that remain within a patient for extended periods of time are prone to bacterial colonization and biofilm formation. When established these bacterial communities are highly resistant to antibiotic treatment. There is a need to establish rapid quantitate methods that can identify important bacterial species. In collaboration with the School of Nursing and local hospitals in Brisbane, we seek to: Develop novel quantitative diagnostic tools to monitor the causal agents of infections within a clinical setting. Animals are host to a wide and diverse range of bacteria that can impact upon, or are required to maintain proper health. An emerging area of research are the impacts that bacteria have on animal behaviour, which for many years have focused exclusively on genetics and the surrounding environment. By combining molecular, and whole organismal techniques my research group seeks to: Identify which bacteria influence complex behaviours in sleep, learning and memory. Determine how are such changes achieved at a gene, biochemical and physiological scale. Insects are commonly infected by a bacterial endosymbiont called Wolbachia, which has been shown to disrupt the replication of viruses within insects. How Wolbachia disrupts viral replication is unclear. My research group seeks to answer: How Wolbachia protect insect hosts against other pathogens such as viruses and fungi? Can Wolbachia be developed as a biological control agent to control the spread of insect transmitted viruses? Temporary medical implants, such as intravenous needles and catheters, that remain within a patient for extended periods of time are prone to bacterial colonization and biofilm formation. When established these bacterial communities are highly resistant to antibiotic treatment. There is a need to establish rapid quantitate methods that can identify important bacterial species. In collaboration with the School of Nursing and local hospitals in Brisbane, we seek to: Develop novel quantitative diagnostic tools to monitor the causal agents of infections within a clinical setting. v

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Wolbachia Influences the Production of Octopamine and Affects Drosophila Male Aggression.Chelsie E Rohrscheib, Elizabeth Bondy, Peter Josh, Markus Riegler, Darryl Eyles, Bruno van Swinderen, Michael W Weible, Jeremy C Brownlie. Appl Environ Microbiol. 2015 Jul;81(14):4573-80. Symbiont-mediated protection in insect hosts. JC Brownlie, KN Johnson. Trends in microbiology 17 (8), 348-354 Wolbachia and virus protection in insects. LM Hedges, JC Brownlie, SL O'Neill, KN Johnson Science 322 (5902), 702-702