研究领域

Ex Situ Conservation of Plant Genetic Resources. Seed biology and conservation. In vitro culture for micropropagation and conservation. Alternative conservation technologies for tropical recalcitrant-seeded species including Australian native fruits and wild crop relatives. Plant improvement using biotechnology approaches. Cryopreservation and cryobiology.

Human parasitic diseases cause major health and economic problems in many tropical and sub-tropical regions of the world. Each year significant morbidity and mortality arises due to infection with parasites that cause diseases such as malaria, schistosomiasis, and lymphatic filariasis. There are currently no vaccines available to prevent tropical parasitic diseases and prophylactic or therapeutic drugs are either failing due to parasite resistance or are just not available. Our work focuses on the worlds’ most lethal tropical parasitic disease, malaria, which is caused by Plasmodium parasites. Each year ~600,000 people, mainly children under the age of five, die of malaria. Malaria parasite drug resistance is a major problem and there is a large unmet need for the identification of new antimalarial drugs, in particular those with and novel modes of action. To address this, our group uses cross-disciplinary approaches to try to identify key weaknesses in the malaria parasite so that we can exploit them to develop new drug leads for malaria prevention and treatment.

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Kaity, A.; Drew, R.A.; Ashmore, S.E. (2013) Genetic and Epigenetic Integrity Assessment of Acclimatised Papaya Plants Regenerated Directly From Shoot-tips Following Short- and Long-term Cryopreservation. Plant Cell Tiss Organ Cult 112:75-86. Ashmore S.E., Hamilton K.N. and Offord C.A. (2011). Conservation Technologies for Safeguarding and Restoring Threatened Flora: Case Studies from Eastern Australia. In Vitro Cellular and Developmental Biology – Plant. 47(1):99-109. Hamilton, K.N., Ashmore, S.E. and Pritchard, H.W. (2009) Thermal Analysis and Cryopreservation of Seeds of Australian Wild citrus Species (Rutaceae): Citrus australasica, C. inodora and C. garrawayi. Cryoletters 30(3): 268-279.