研究领域

Organic Chemistry

Our research programme revolves around the theme of synthesis and encompasses broadly based studies directed towards the design and development of new methods, reagents and strategies for the synthesis of biologically active molecules. Specific research areas of current interest include the following:

近期论文

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'Anomalous Nuclear Overhauser Effects in Carbon-Substituted Aziridines: Scalar Cross-Relaxation of the First Kind' I. Kuprov, D. M. Hodgson, J. Kloesges, C. I. Pearson, B. Odell and T. D. W. Claridge, Angew. Chem., Int. Ed., 2015, 54, in press. DOI: 10.1002/anie.201410271 'Amine Protection/α-Activation with the tert-Butoxythiocarbonyl Group: Application to Azetidine Lithiation-Electrophilic Substitution' D. M. Hodgson, C. L. Mortimer and J. M. McKenna, Org. Lett., 2015, 17, 330. DOI: 10.1021/ol503441d 'Intramolecular Oxonium Ylide Formation-[2,3] Sigmatropic Rearrangement of Diazocarbonyl-Substituted Cyclic Unsaturated Acetals: A Formal Synthesis of Hyperolactone C' D. M. Hodgson, S. Man, K. J. Powell, Z. Perko, M. Zeng, E. Moreno-Clavijo, A. L. Thompson and M. D. Moore, J. Org. Chem., 2014, 79, 9728. DOI: 10.1021/jo501893r 'Generation and Electrophile Trapping of N-Boc-2-Lithio-2-azetine: Synthesis of 2-Substituted-2-Azetines' D. M. Hodgson, C. I. Pearson and M. Kazmi, Org. Lett., 2014, 16, 856. DOI: 10.1021/ol403626k 'An Approach to Hyperolactone C and Analogues using Late Stage Conjugate Addition on an Oxonium Ylide-Derived Spirofuranone' D. M. Hodgson, E. Moreno-Clavijo, S. E. Day and S. Man, Org. Biomol. Chem., 2013, 11, 5362. DOI: 10.1039/C3OB41251B 'C-Alkylation of Chiral Tropane- and Homotropane-Derived Enamines' D. M. Hodgson, A. Charlton, R. S. Paton and A. L. Thompson, J. Org. Chem. 2013, 78, 1508. DOI: 10.1021/jo3025972 'α-Lithiation–Electrophile Trapping of N-Thiopivaloylazetidin-3-ol: Stereoselective Synthesis of 2-Substituted-3-hydroxyazetidines' D. M. Hodgson, C. I. Pearson and A. L. Thompson, J. Org. Chem. 2013, 78, 1098. DOI: 10.1021/jo3025225 'Alkenes from β-lithiooxyphosphonium ylides generated by trapping α-lithiated terminal epoxides with triphenylphosphine' D. M. Hodgson and R. S. D. Persaud, Beilstein J. Org. Chem. 2012, 8, 1896. DOI: 10.3762/bjoc.8.219 'Convergent Synthesis of Conjugated 1,2-Disubstituted E-Allylic Alcohols from Two Aldehydes and Methylenetriphenylphosphorane' D. M. Hodgson and R. S. D. Persaud, Org. Biomol. Chem., 2012, 10, 7949. DOI: 10.1039/C2OB26346G 'syn-β-Hydroxyallylic Silanes from Terminal Epoxide α-Lithiation-Silylation and Alkenylation: Application to the Tetrahydrofuran Portion of the Lytophilippines'. D. M. Hodgson and S. Salik, Org. Lett., 2012, 14, 4402. DOI: 10.1021/ol3018853 'Synthesis of the Anti-trypanosomal Agent (�)- Hydroxyanthecotulide by Cr(II)-catalysed Allylation and Meyer-Schuster Rearrangement' D. M. Hodgson, E. P. A. Talbot and B. P. Clark, Chem. Commun., 2012, 48, 6349. Highlighted on the Chemical Communications blog. DOI: 10.1039/C2CC32283H 'Unusual Base-Induced Rearrangement of exo-9-Oxabicyclo[4.2.1]non-7-ene Oxide to exo-8-Hydroxybicyclo[3.3.0]octan-2-one' D. M. Hodgson, M. A. H. Stent, R. S. Paton and F. X. Wilson, Heterocycles, 2012, 84, 625. (Prof. A Padwa 75th Birthday Issue). DOI: 10.3987/COM-11-S(P)35 'Catalytic Asymmetric Synthesis of (+)-Anthecotulide Using Enyne and Meyer–Schuster Rearrangements' D. M. Hodgson, E. P. A. Talbot, and B. P. Clark, Org. Lett. 2011, 13, 5751. DOI: 10.1021/ol202425e 'Synthesis of the Anti-HIV Agent (-)-Hyperolactone C by using Oxonium Ylide Formation- Rearrangement' D. M. Hodgson and S. Man, Chem. Eur. J., 2011, 17, 9731. DOI: 10.1002/chem.201101082 'Stereoselective Synthesis of β-(Hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones' D. M. Hodgson, E. P. A. Talbot and B. P. Clark, Org. Lett., 2011, 13, 2594. DOI: 10.1021/ol200711f 'Disubstituted Z-Allylic Esters by Wittig-Schlosser Reaction using Methylenetriphenylphosphorane' D. M. Hodgson and T. Arif, Chem. Commun., 2011, 47, 2685. DOI: 10.1039/C0CC04429F 'α,β-Aziridinylphosphonates by Lithium Amide-Induced Phosphonyl Migration from N to C in Terminal Aziridines' D. M. Hodgson and X. Zu, Beilstein J. Org. Chem., 2010, 6, 978. DOI:10.3762/bjoc.6.110 'Convergent Synthesis of Trisubstituted Z-Allylic Esters by Wittig-Schlosser Reaction' D. M. Hodgson and T. Arif, Org. Lett., 2010, 12, 4204. DOI: 10.1021/ol101843q 'Synthetic and Computational Studies on the Tricarboxylate Core of 6,7-Dideoxysqualestatin H5 Involving a Carbonyl Ylide Cycloaddition-Rearrangement' D. M. Hodgson, C. Villalonga-Barber, J. M. Goodman and S.C. Pellegrinet, Org. Biomol. Chem., 2010, 8, 3975. DOI: 10.1039/c004496b 'Epoxide Opening-Induced Tandem 8-Azabicyclo[3.2.1]octane to 6-Azabicyclo[3.2.1]octane Rearrangement-Iminium Allylation: Synthesis of (�)-Peduncularine' D. M. Hodgson, R. E. Shelton, T. A. Moss and M. Dekhane, Org. Lett., 2010, 12, 2834. DOI: 10.1021/ol100943j 'Transition States and Origins of 1,4-Asymmetric Induction in Alkylations of 2,2,6-Trialkylpiperidine Enamines' J. M. Um, N. S. Kaka, D. M. Hodgson and K. N. Houk, Chem. Eur. J., 2010, 16, 6310. DOI: 10.1002/chem.201000046