Else, Paul L. - University of Wollongong

个人简介

2010-11 – Faculty Research Chair 2000-05 – Head, Department of Biomedical Sciences, UOW 2003 – Visiting Research Fellow (Dept Chemistry), University of Sydney 1991-94 – School Biological and Chemical Sciences, Deakin University 1990 – School of Science and Technology, Charles Sturt University 1986-90 – Dept Zoology, University of Melbourne 1986 – Postdoctoral Fellow, Division of Human Nutrition, C.S.I.R.O. 1984-85 – Postdoctoral Fellow, Dept Developmental and Cell Biology, University of California, Irvine, U.S.A.

研究领域

Understanding the role of membrane lipids in the biology of organisms. Notably, how membrane lipids influence the activities of membrane bound proteins and how peroxidation (oxidation) of polyunsaturated fatty acids fits into the normal (healthy) and abnormal (disease) functioning of cells.

近期论文

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Else PL (2013) Dinosaur Lactation? Journal of Experimental Biology. 216 (3): 347-51. Controversial hypothetical that generated lively debate on international science and general media forums by proposing a form of lactation in some dinosaurs (Journal IF = 3.0). Makrides M, Gibson RA, McPhee AJ, Yelland L, Quinlivan J, Ryan P, Doyle LW, Anderson P, Else PL, Meyer BJ, Colditz P, Pritchard M, Zhou S, Collins CT, Gulpers Z, McCusker S, Naccarella N, Best K, Loudis H, Anderson A, Griffith E (2010) Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: A randomized controlled trial. JAMA. 304(15):1675-1683. Large clinical trial showing that supplementation with DHA in the diet of pregnant women does not change rates of postnatal depression (Times cited = 59; Journal IF = 30.0) Hulbert AJ, Turner N, Storlien LH and Else PL (2005) Dietary fats and membrane function: implications for metabolism and disease. Biological Reviews. 80:155-169. Major review on membrane pacemaker concept and the relationships between diet and membrane lipids. (Times cited = 111, Journal IF = 9.07) Wu BJ, Hulbert AJ, Storlien LH and Else PL (2004) Membrane lipids and sodium pumps of cattle and crocodiles: An experimental test of the membrane pacemaker theory of metabolism. American Journal of Physiology. 287:R633-R641. Elegant test of our membrane pacemaker theory using species membrane swap-overs showing predictable changes in sodium pump molecular activity. (Times Cited = 40; Journal IF = 3.3) Hulbert AJ and Else PL (2000) Mechanisms underlying the cost of living in vertebrates. Annual Review of Physiol. 62:237-60. Special invited review on a major topic in animal biology including the membrane pacemaker theory. (Times cited = 154; Journal IF = 20.8) Else PL and Wu BJ (1999) What role for membranes in determining the higher sodium pump molecular activity of mammals compared to ectotherms? Journal of Comparative Physiology B. 169:296-302. First paper to show that swapping membrane lipids of endotherms and ectotherms could produce predictable alterations in sodium pump activity. (Times cited = 57: Journal IF = 2.0) Hulbert AJ and Else PL (1999) Membranes as possible pacemakers of metabolism. Journal of Theoretical Biology. 199: 357-374. First paper outlining the membrane pacemaker theory of metabolism. Written from the ideas contained within the ARC DP Grant A10012998. (Times cited = 112: Journal IF = 2.4) Else PL, Windmill DJ & Markus V (1996) Molecular activity of sodium pumps in endotherms and ectotherms. American Journal of Physiology. 271(5):R1287-R1294. Shows higher sodium pump activity in endotherms (versus ectotherms) due to differences in the pump rate not sodium pump concentration. (Times cited = 43; Journal IF = 3.3) Brand MD, Couture P, Else PL, Withers KW and Hulbert AJ (1991) Evolution of energy metabolism: Proton permeability of the inner membrane of liver mitochondria is greater in a mammal than in a reptile. Biochemical Journal. 275:81-86. The first paper to show that mitochondrial proton permeability differs between endotherms and ectotherms and is a source of increased metabolic rate in endotherms. (Times cited = 182; Journal IF = 4.9) Else PL and Hulbert AJ (1987) Evolution of mammalian endothermic metabolism: "Leaky" membranes as a source of heat. American Journal of Physiology. 253(1): R1-R7. ‘Classic’ paper demonstrating new concept, that ionic permeabilities of endotherm and ectotherm cells are fundamentally different and part of the increased metabolic rate in endotherms. (Times cited = 103; Journal IF = 3.3)