Deng, Chao - University of Wollongong

研究领域

Investigate neuropharmacological mechanisms of antipsychotic drugs underlying their pharmacological efficacy and side-effects, and test a H1 receptor agonist in the prevention of olanzapine-induced obesity in animal trails; To reveal the in vivo mechanisms underlying the clinical efficacy and reduced side-effects of the functionally selective antipsychotic drug, aripiprazole; The neural mechanisms for the regulation of body weight in the brainstem, in particular the roles of the brainstem in the development of obesity.

近期论文

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Han M, Huang X-F, Deng C. (2009) Aripiprazole differentially affects mesolimbic and nigrostriatal dopaminergic transmission: implications for long-term drug efficacy and low extrapyramidal side-effects. International Journal of Neuropsychopharmacology 12:941-952. Weston-Green K, Huang X-F, Han M, Deng C. (2008) The effects of antipsychotics on the density of cannabinoid receptors in the dorsal vagal complex of rats: Implications for olanzapine-induced weight gain. International Journal of Neuropsychopharmacology 11:827-825. Han M., Deng C, Burne THJ, Newell K, and Huang X-F. (2008) Short- and long-term effects of antipsychotic drug treatment on weight gain and H1 receptor expression. Psychoneuroendocrinology 33:569-580. Rahardjo GL, Huang XF, Tan YY, and Deng C. (2007) Decreased plasma PYY accompanied by an elevated PYY and Y2 receptor binding sites in the medulla oblongata of diet-induced obese mice. Endocrinology 148:4704-4710. Deng, C and Huang, X-F. (2005) Decreased Density of Muscarinic Receptors in the Superior Temporal Gyrus in Schizophrenia. Journal of Neuroscience Research 81:883-890.