Hyland, Chris - University of Wollongong

个人简介

Qualifications PhD, Imperial College, London, 2004. MSc., Imperial College, London, 2000. Positions Held Senior Lecturer, School of Chemistry, University of Wollongong. 2012 - present Assistant Professor, Department of Chemistry and Biochemistry, California State University, Fullerton. 2006-2012. (on leave at the University of Tasmania as a Lecturer from 2010-2012). Postdoctoral Fellow, Department of Chemistry, Colorado State University (Group of Professor Louis Hegedus), 2004-2006

研究领域

Synthesis, Catalysis and Medicinal Chemistry My group is interested in developing new transition metal-catalysed reactions for the synthesis of small organic molecules. We aim to develop tools for chemists to build complex molecules that may be used in new pharmaceuticals or materials. There is a particular focus on developing reactions that are efficient and selective so as to reduce waste and energy consumption. Through collaborations we also aim to harness synthetic chemistry to learn more about biological systems and develop potential new therapeutics.

近期论文

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Medicinal Organometallic Chemistry - an Emerging Strategy for the Treatment for Neglected Tropical Diseases. Brown, R. B.; Hyland, C. J. T. MedChemComm., 2015, 6, 1230-1243. Ring-Opening of Vinylcyclopropane-1,1-dicarboxylates by Boronic Acids under Ligandless Palladium Catalysis in Neat Water. Yin, J.; Hyland, C. J. T. J. Org. Chem., 2015, 80, 6529. Cover Article Unusual (Z)-Selective Palladium(II)-Catalysed Addition of Aryl Boronic Acids to Vinylaziridines. Yin, J.; Mekelburg, T.; Hyland, C. J. T. Org. Biomol. Chem., 2014, 12, 9113. Synthesis of Nitrogen-Substituted Methylenecyclopropanes by Strain-Driven Overman Rearrangement of Cyclopropenylmethyl Trichloroacetimidates. Howard, J. K.; Amin, C.; Lainhart, B.; Smith, J. A.; Rimington, J.; Hyland, C. J. T. J. Org. Chem., 2014, 79, 8462. Deans, RM, Gardiner, MG, Horne, J, Hung, AC, Hyland, C, Just, J, Smith, JA, Yin, JY, 'Isolation and characterization of 1β-Acetoxypolygodial from Tasmannia Lanceolata', Asian J. Org. Chem., 2014, 3, 1193. 3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis. Ferrins, L.; Rahmani, R.; Sykes, M. L.; Jones, A.; Avery, V. M.; Teston, E.; Almohaywi, B.; Yin, J.; Smith, J.; Hyland, C. J. T.; White, K. L.; Ryan, E.; Campbell, M.; Charman, S. A.; Kaiser, M.; Baell, J. B. Eur. J. Med. Chem. 2013, 66, 450 Theoretical Study on the Ring-Opening Reactions of Cyclopropenes Mediated by a AuI Complex. Rajabi, N. A.; Atashgah, M. J.; BabaAhmadi, R.; Hyland, C.; Ariafard, A. J. Org. Chem. 2013, 78, 9553. Synthetic methods Part (ii) Oxidation and reduction methods. Gee, Y. S.; Abd El Kader, K. F.; Hyland, C. J. T. Annu. Rep. Prog. Chem., Sect. B: Org. Chem. 2013, 109, 103-125. Controlled Oxidation of Pyrroles: Synthesis of Highly Functionalized γ-Lactams: Howard, J. K.; Hyland, C. J. T.; Just, J.; Smith, J. A. Org. Lett. 2013, 15, 1714. Synthetic methods Part (ii) Oxidation and reduction methods. Howard J. K.; Hyland, C. J. T. Annu. Rep. Prog. Chem., Sect. B: Org. Chem., 2012, 108, 29. Theoretical Investigation into the Palladium-Catalyzed Silaboration of Pyridines, Yates, B.; Ariafard, A.; Hyland, C. J. T.; Monfared, A.; Assar, S. Organometallics 2012, 31, 1680. Ryan, J. H.; Hyland, C.; Meyer, A.; Smith, J. A.; Yin, JieXiang. Seven-Membered Rings. Progress in Heterocyclic Chemistry; Elsevier: Great Britain, 2012; Volume 24, pp 493. Ryan, J. H.; Smith, J. A.; Hyland, C.; Green, J. Seven-Membered Rings. Progress in Heterocyclic Chemistry; Elsevier: Great Britain, 2011; Volume 23, pp 465. Chemoselective Reduction of 2-Acyl-N-sulfonylpyrroles: Synthesis of 3-Pyrrolines and 2-Alkylpyrroles, Smith, J. A.; Molesworth, P. P.; Hyland, C.; Howard, J.; Just, J. J. Org. Biomol. Chem., 2011, 9, 3948. Theoretical Investigation into the Mechanism of Reductive Elimination from Bimetallic Palladium Complexes. Ariafard, A.; Hyland, C.; Sharma, M.; Brookes, N.; Yates, B.; Canty, A. Inorganic Chemistry. 2011, 50, 6449. A Titanium-Mediated Rearrangement of Cyclopropenylmethyl Acetates to (E)-Halodienes. Gallego, G.; Ariafard. A.; Tran, K.; Sandoval, D.; Choi, L. Chen, Y-H.; Yates, B. F.; Tao, F-M.; Hyland, C. J. T. Org. Biomol. Chem., 2011, 9, 3359.