Kelso, Michael - University of Wollongong

个人简介

Academic Qualifications B.Med. Chem. (Hons 1), University of Wollongong, 1996 (University Medal for the Faculty of Science) Ph.D., Institute for Molecular Bioscience, University of Queensland, 2002 (with Professor David Fairlie) Positions held Senior Lecturer, School of Chemistry, University of Wollongong, Australia. January 2010 - Current. Lecturer, School of Chemistry, University of Wollongong, Australia. January 2008-2009. NHMRC CJ Martin Research Fellow, School of Chemistry, University of Wollongong, Australia. January 2006 - January 2008. NHMRC CJ Martin Research Fellow, Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA (with Professor Dale Boger) January 2004 - December 2005. Postdoctoral Research Fellow, Universidad del Pais Vasco, San Sebastian, Spain (with Professor Claudio Palomo and Professor Mikel Oiarbide) December 2002 - December 2003. Postdoctoral Research Fellow, Institute for Molecular Bioscience, University of Queensland (with Professor David Fairlie) March 2002 - November 2002.

研究领域

Medicinal chemistry, drug design and synthesis, structure-based drug design, prodrug design and synthesis, anti-tumour agents, anti-microbial agents, DNA binding anthracyclines, biofilm dispersing agents, catalytic asymmetric synthesis.

近期论文

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Synthesis of Cephalosporin-3′-Diazeniumdiolates: Biofilm Dispersing NO-Donor Prodrugs Activated by b-Lactamase. Yepuri, N. R.; Barraud, N.; Mohammadi, N. S.; Kardak, B. G.; Kjelleberg, S.; Rice, S. A.; Kelso, M. J. Chem. Commun. 2013, 49, 4791-4793. Cephalosporin-3′-Diazeniumdiolates: Targeted NO-Donor Prodrugs for Dispersing Bacterial Biofilms. Barraud, N.; Kardak, B. G.; Yepuri, N.R.; Howlin, R.P.; Webb, J. S; Faust, S. N.; Kjelleberg, S.; Rice, S. A.; Kelso, M. J. Angew. Chem. Int. Ed. 2012, 51, 9057-9060. Strategies to Potentiate Antimicrobial Photoinactivation by Overcoming Resistant Phenotypes. Vera, D. M. A.; Haynes, M. H.; Ball, A. R.; Dai, T.; Astrakas, C.; Kelso, M. J.; Hamblin, M. R.; Tegos, G. P. Photochem. Photobiol. 2012, 88, 499–511. Synthesis and Preliminary Evaluation of Amiloride Analogs as Inhibitors of the Urokinase-Type Plasminogen Activator. Matthews, H.; Ranson, M.; Tyndall, J. D. A.; Kelso, M. J. Bioorg. Med. Chem. Lett. 2011, 21, 6760-6766. Small Molecule Antagonists of the Urokinase (uPA):Urokinase Receptor (uPAR) Interaction with High Reported Potencies Show Only Weak Effects in Cell-Based Competition Assays Employing the Native uPAR Ligand. De Souza, M.; Matthews, H.; Lee, J. A.; Ranson, M.; Kelso, M. J. Bioorg. Med. Chem. 2011, 19, 2549-2556. Anti-Tumour/Metastasis Effects of the Potassium-Sparing Diuretic Amiloride: An Orally Active Anti-Cancer Drug Waiting for its Call-of-Duty? Matthews, H.; Ranson, M.; Kelso, M. J. Int. J. Cancer 2011, 129, 2051-2061. Synthesis of Berberine−Efflux Pump Inhibitor Hybrid Antibacterials. Bremner, J. B.; Kelso, M. J. Synthetic Commun. 2010, 40, 3561-3568. A Mass Spectrometric Investigation of Novel Quadruplex DNA-selective Berberine Derivatives. Gornall, K. C.; Samosorn, S.; Tanwirat, B.; Suksamrarn, A.; Bremner, J. B.; Kelso, M. J.; Beck, J. L. Chem. Commun. 2010, 46, 6602-6604. Berberine−INF55 (5-Nitro-2-Phenylindole) Hybrid Antimicrobials: Effects of Varying the Relative Orientation of the Berberine and INF55 Components. Tomkiewicz, D.; Casadei, G.; Larkins-Ford, J.; Moy, T.I.; Garner, J.; Bremner, J. B.; Ausubel, F. M.; Lewis, K.; Kelso, M. J. Antimicrobial Agents and Chemother. 2010, 54, 3219-3224. Inhibitors of the Plasminogen Activation System – Promising New Agents for Suppressing Breast Cancer Metastasis. Tyndall, J. D. A.; Kelso, M. J.; Ranson, M. in Frontiers in Anti-Cancer Drug Discovery 2010, 1, 55-78. Linkage Isomerism in the Binding of Pentapeptide Ac-His(Ala)3His-NH2 to (Ethylenediamine)Palladium(II): Effect of the Binding Mode on Peptide Conformation. Hoang, H. N.; Bryant, G. K.; Kelso, M. J.; Beyer, R. L. Appleton, T. G.; Fairlie, D. P. Inorg. Chem. 2008, 47, 9439-9449. Structure–Activity Relationships of 2-aryl-1H-indole Inhibitors of the NorA Efflux Pump in Staphylococcus aureus. Ambrus, J. A.; Kelso, M. J.; Bremner, J. B.; Ball, A. R.; Casadei, G.; Lewis, K. Bioorg. Med. Chem. Lett. 2008, 18, 4294-4297. Oxidative Coupling of Indoles Using Thallium (III) Trifluoroacetate. Keller, P. A.; Yepuri, N. R.; Kelso, M. J.; Mariani, M.; Skelton, B. W.; White, A. H. Tetrahedron, 2008, 64, 7787-7795. Peptides and Small Molecules Targeting the Plasminogen Activation System: Towards Prophylactic Anti-Metastasis Drugs for Breast Cancer. Tyndall, J. D. A.; Kelso, M. J.; Clingan, P.; Ranson, M. Recent Patents on Anti-Cancer Drug Discovery. 2008, 3, 1-13. Synthesis of an Anthracyclinone Bearing an Unprecedented Aromatic Ring-Fused Bridgehead-Hydroxylated Bicyclo[3.1.1]heptanol. Kelso, C.; Beck, J.L.; Kelso, M.J. Tetrahedron Lett. 2007, 48, 7440-7443. Structure-Activity Relationships of Alpha-Ketooxazole Inhibitors of Fatty Acid Amide Hydrolase. Hardouin C.; Kelso, M.J.; Romero, F.A.; Rayl, T. J.; Leung, D.; Hwang, I.; Cravatt, B. F.; Boger, D. L. J. Med. Chem. 2007, 50(14), 3359-3368.