Ooi, Lezanne - University of Wollongong - School of Biological Sciences

个人简介

2015-date Senior Lecturer, School of Biological Sciences, University of Wollongong 2012-2014 Lecturer, School of Biological Sciences, University of Wollongong 2011-2012 School of Medicine, University of Western Sydney 2008-2011 Postdoctoral research fellow, Institute of Membrane and Systems Biology, University of Leeds, UK 2002-2006 Wellcome Trust prize PhD studentship. School of Biochemistry and Molecular Biology, University of Leeds, UK

研究领域

Use of induced pluripotent stem cells in neurodegenerative disease modelling and drug discovery. Effects of inflammation and oxidative stress on neuronal function. Identification of neuroprotective genes and drugs. Global control of gene expression and protein function: transcriptional regulation and epigenetics.

近期论文

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Engel M, Do-Ha D, Muñoz SS, Ooi L. Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and research. Cellular and Molecular Life Sciences 2016 doi: 10.1007/s00018-016-2265-3. Yerbury JJ, Ooi L, Dillin A, Saunders DN, Hatters DM, Beart PM, Cashman NR, Wilson MR, Ecroyd H. Walking the tightrope: Proteostasis and neurodegenerative disease. Journal of Neurochemistry. 2016 137(4):489-505. doi: 10.1111/jnc.13575. Sobrevia L, Ooi L, Ryan S, Steinert JR. Nitric Oxide: A Regulator of Cellular Function in Health and Disease. Oxidative Medicine and Cellular Longevity. 2016 2016:9782346. doi: 10.1155/2016/9782346. Balez R and Ooi L. Getting to NO Alzheimer’s Disease: Neuroprotection versus Neurotoxicity Mediated by Nitric Oxide. Oxidative Medicine and Cellular Longevity. 2016 2016:3806157. doi: 10.1155/2016/3806157. Steiner N, Balez R, Karunaweera N, Lind JM, Münch G, Ooi L. Neuroprotection of Neuro2a cells and the cytokine suppressive and anti-inflammatory mode of action of resveratrol in activated RAW264.7 macrophages and C8-B4 microglia. Neurochem Int. 2015 Oct 29. pii: S0197-0186(15)30063-2. doi: 10.1016/j.neuint.2015.10.013. Zeineddine R, Pundavela JF, Corcoran L, Stewart EM, Do-Ha D, Bax M, Guillemin G, Vine KL, Hatters DM, Ecroyd H, Dobson CM, Turner BJ, Ooi L, Wilson MR, Cashman NR, Yerbury JJ. SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation. 2015 Molecular Neurodegeneration Oct 31;10:57. Yang S, Zhang KY, Kariawasam R, Bax M, Fifita JA, Ooi L, Yerbury JJ, Nicholson GA, Blair IP. Evaluation of Skin Fibroblasts from Amyotrophic Lateral Sclerosis Patients for the Rapid Study of Pathological Features. Neurotoxicty Research 2015 Aug;28(2):138-46. Gamper N and Ooi L. Redox and nitric-oxide-mediated regulation of sensory neuron ion channel function. Antioxidants and redox signalling 2015 22:486-504. Gunawardena D, Bennett L, Shanmugam K, King K, Williams R, Zabaras D, Head R, Ooi L, Gyengesi E, Münch G. Anti-inflammatory effects of five commercially available mushroom species determined in lipopolysaccharide and interferon-γ activated murine macrophages. Food Chem. 2014 Apr 1;148:92-6. Ooi L, Gigout S, Pettinger L and Gamper N. Triple cysteine module within M-type K+ channels mediates reciprocal channel modulation by nitric oxide and reactive oxygen species. Journal of Neuroscience 2013 33: 6041-6. Steele ML, Fuller S, Patel M, Kersaitis C, Ooi L, Münch G. Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells. Redox Biology 2013 1:441-5. Nguyen NTQ, Ooi L, Piller SC and Münch G. Pro-energetic effect of resveratrol in the murine neuronal cell line Neuro2a. Molecular Nutrition & Food Research 2013 57:1901-7. Laurenti D and Ooi L. Mammalian expression systems and transfection techniques. Methods Mol Biol. 2013 998:21-32.