个人简介

Edgar A Arriaga Univ. of Minnesota Dept. of Chemistry A-1, 139 Smith Hall 207 Pleasant St. SE Minneapolis, MN 55455-0431

研究领域

Analytical & Bioanalytical Chemistry/Chemical Biology

Our research efforts combine expertise in bioanalytical chemistry, chemical biology, and biomedical engineering. We develop unique methods and instrumentation to characterize the chemical, biochemical, and physiological properties of single biological cells and their subcellular components (organelles). These resources enable single cell and subcellular studies that are essential to investigate biological complexity, which presently sets limitations to the research carried out in the biomedical and biotechnological fields. Within these fields we strive to help answers key questions related to the aging process, diabetes and obesity and neurodegeneration as we apply our developments to biological models including mammalian cell cultures, murine and human skeletal muscle, and Caenorhabditis elegans. Arriaga Organelle Group Summer 2014

近期论文

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Wolken, G.G.; Arriaga, E.A. "Simultaneous measurement of individual mitochondrial membrane potential and electrophoretic mobility by capillary electrophoresis." Analytical Chemistry, 86(9) (2014); 4217-26 Hahn W.S.; Kuzmicic J.; Burrill J.S.; Donoghue M.A.; Foncea R.; Jensen M.D.; Lavandero S.; Arriaga E.A.; Bernlohr D.A. "Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics." American journal of physiology. Endocrinology and metabolism, 306(9) (2014); E1033-45 Satori C.P.; Meyer B.; Arriaga E.A. "Monitoring subcellular biotransformation of N-L-leucyldoxorubicin by micellar electrokinetic capillary chromatography coupled to laser-induced fluorescence detection." Analytical and Bioanalytical Chemistry 406(9-10) (2014); 2389-97 Luo J.; Abdallah B.G.; Wolken G.G.; Arriaga E.A.; Ros A. "Insulator-based dielectrophoresis of mitochondria." Biomicrofluidics 8(2) (2014); 021801 Taylor T.H.; Frost N.W.; Bowser M.T.; Arriaga E.A. "Analysis of individual mitochondria via fluorescent immunolabeling with Anti-TOM22 antibodies." Analytical Bioanalytical Chemistry 406(6) (2014); 1683-91 Ochocki J.D.; Igbavboa U.; Wood W.G.; Arriaga E.A.; Wattenberg E.V.; Distefano M.D. "Evaluation of prenylated peptides for use in cellular imaging and biochemical analysis." Methods in Molecular Biology 1088 (2014); 213-23 Satori C.P.; Arriaga E.A. "Describing autophagy via analysis of individual organelles by capillary electrophoresis with laser induced fluorescence detection." Analytical Chemistry 85(23) (2013); 11391-400 Ro S.H.;, Jung C.H.; Hahn W.S.; Xu X.; Kim Y.M.; Yun Y.S.; Park J.M.; Kim K.H.; Seo M.; Ha T.Y.; Arriaga E.A.; Bernlohr D.A.; Kim D.H. "Distinct functions of Ulk1 and Ulk2 in the regulation of lipid metabolism in adipocytes." Autophagy 9(12) (2103); 2103-14 Donoghue M.A.; Xu X.; Bernlohr D.A.; Arriaga E.A. "Capillary electrophoretic analysis of hydroxyl radicals produced by respiring mitochondria." Analytical and Bioanalytical Chemistry 405(18) (2013); 6053-60 Satori C.P.; Henderson M.M.; Krautkramer E.A.; Kostal V.; Distefano M.D.; Arriaga E.A. "Bioanalysis of eukaryotic organelles." Chemical Reviews 113(4) (2013); 2733-811