个人简介
项楠 副教授
职称 副教授/博导
办公室 机械楼203 微流控实验室
个人简介
项楠,副教授/博导,江苏省优青,江苏省优博,东南大学首批“至善青年学者”(A层次),江苏省“六大人才高峰”高层次人才。
已在Lab on a Chip (IF=6.774)、Analytical Chemistry (IF=6.785)等国际期刊发表SCI论文57篇。其中,包括封面论文和研究亮点论文8篇,南京市自然科学优秀学术论文一等奖获奖论文1篇,发表于Nanotechnology的封面论文被英国皇家物理学会做大篇幅专题报道。研究工作被他引500余次,其中被来自哈佛大学、麻省理工学院、加州大学洛杉矶分校等高校的知名学者作为重要研究进展进行图片引用30余次。受邀为斯普林格出版的英文专业书籍《Handbook of Single Cell Technologies》撰写“惯性微流控单细胞分析技术”章节。
主持国家自然科学面上/青年基金、江苏省优青等科研或人才项目7项,以排名第二参研国家自然科学重大科研仪器研制项目等国家级科研项目4项。系列研究成果共计授权发明专利24项,申请国际PCT专利2项,公示发明专利12项。受邀担任国际微流体学术会议及ASME会议的分会场主席或子专题组织者,担任20余个国际学术期刊的审稿人。
所负责的微流控课题组一直从事新型医疗仪器及微机电系统产品的设计与制造,及其所涉及精密加工、微操控和精准检测基础科学问题的研究。派遣研究生前往哈佛大学等知名高校联合培养,毕业博士生就职于江苏各大高校,硕士生就职于华为、迈瑞、大众、飞利浦等企业或研究所。
欢迎优秀学子加入课题组攻读硕士及博士学位!欢迎联系咨询!邮箱:nan.xiang@seu.edu.cn;电话:15298362508。
学习经历
2005年9月-2009年6月,浙江大学,本科/学士
2009年9月-2014年12月,东南大学,机械制造及其自动化,研究生/博士
工作经历
2015年1月-2017年10月,东南大学,机械工程学院,讲师
2017年11月-至今,东南大学,机械工程学院,副教授(破格)/博导
教授课程
机械制图
生物微流体技术
获奖情况
2019年江苏省优青
2018年东南大学首批“至善青年学者”(A层次)
2017年江苏省“六大人才高峰”高层次人才计划
2016年江苏省优秀博士学位论文
2018年南京市第十二届自然科学优秀学术论文一等奖
2016年东南大学优秀博士学位论文
2016年中泰国立奖教金三等奖
2013年研究生国家奖学金
2012年研究生国家奖学金
审稿期刊
Lab on a Chip, Small, ACS Nano, Biosensors and Bioelectronics, Analytical Chemistry, ACS Sensors, Langmuir, Analytica Chimica Acta, Biomedical Microdevices, Biotechnology Journal, ELECTROPHORESIS, Royal Society Open Science, Microfluidics and Nanofluidics, Scientific Reports, Biomicrofluidics, Sensor, Physics of Fluids, Journal of Visualized Experiments, IEEE Transactions on Biomedical Circuits and Systems, IEEE Journal of Biomedical and Health Informatics, Journal of Micromechanics and Microengineering, Particuology, IEEE Sensors, Extreme Mechanics Letter, 物理学报等。
科研项目 项目名称 项目类别 项目时间 工作类别 项目金额
基于电指纹差异的循环肿瘤细胞精准检测芯片研究
国家自然科学基金面上项目 (51875103)
2019/01-2022/12
负责人
60万元
微流控仪器的设计与制造
江苏省优青 (BK20190064)
2019/07-2022/06
负责人
50万元
东南大学至善青年学者 (A层次)
人才项目
2018
负责人
30万元
形变和形状特性对生物粒子惯性迁移行为的影响机理研究
国家自然科学基金青年项目 (51505082)
2016/01-2018/12
负责人
26万元
复杂特性生物细胞惯性聚焦机理及其应用研究
江苏省自然科学基金青年项目 (BK20150606)
2015/07-2018/06
负责人
20万元
第十四批“六大人才高峰”高层次人才计划 (C类)
人才项目
2017
负责人
4万元
面向稀有循环肿瘤细胞的非标记精准检测仪器研制
自然科学基金委重大科研仪器研制项目(81727801)
2018/01-2022/12
参加 (排名第二)
690万元
全血中稀有循环肿瘤细胞的精准表征方法研究
国家自然科学基金面上项目(51775111)
2018/01-2021/12
负责人
11万元
稀有细胞精准电阻抗表征的装置开发研究
东南大学高水平论文专项
2017/03-2018/12
参加 (排名第二)
62万元
基于惯性微流控技术的生物细胞聚焦机理及分选应用研究
流体动力与机电系统国家重点实验室开放基金 (GZKF-201501)
2015/12-2017/12
负责人
5万元
新型螺旋流道芯片粒子聚焦机理的理论和实验研究
新进教师科研启动经费
2015/01-2015/12
负责人
10万元
基于惯性及介电泳技术的循环肿瘤细胞多级分选装置研究
国家自然科学基金面上项目(81572906)
2016/01-2018/12
参加 (排名第二)
77.6万元
单根精度纳米线的高柔性与大规模操控技术研究
国家自然科学基金面上项目 (51375089)
2014/01-2017/12
参加 (排名第三)
90万元
基于惯性微流控技术的微纳米粒子操控机理的研究
国家自然科学基金科学部主任基金 (51145009)
2012/01-2012/12
参加 (排名第二)
10万元
基于惯性微流控技术的微纳米粒子分选方法研究
高等学校博士学科点专项科研基金博导类课题 (20110092110003)
2012/01-2014/12
参加 (排名第二)
12万元
基于Dean 惯性流的微纳米粒子自组装芯片研究
江苏省自然科学基金面上项目 (BK2011336)
2011/07-2014/07
参加 (排名第二)
15万元
专利 专利号 专利名称 专利类型
PCT/CN2017/104365
HIGH-THROUGHPUT SORTING AND ENRICHMENT MICROFLUIDIC CHIP FOR TUMOUR CELLS
PCT专利
PCT/CN2020/075732
MICROFLUIDIC DEVICE FOR SEPARATING WHITE BLOOD CELLS
PCT专利
ZL 201910922616.7
一种白细胞提取装置
发明专利
ZL 201910922272.X
一种微混合微流控芯片
发明专利
ZL 201811298537.5
集成惯性与确定性侧向位移技术的稀有细胞多级分选微流控器件
发明专利
ZL 201810346348.4
一种机械驱动的精确进样装置
发明专利
ZL 201810285547.9
基于宽频电阻抗检测芯片的细胞检测方法
发明专利
ZL 201810268556.7
三维螺旋结构细胞分选微流控芯片及其制作方
发明专利
ZL 201711414340.9
包括微流控芯片的循环肿瘤细胞检测仪器
发明专利
ZL 201711248886.1
微米粒子高通量富集微流控芯片
发明专利
ZL 201710872818.6
一种分选细胞的微流控器件及其使用方法
发明专利
ZL 201710816147.1
微流控注射器滤头及其使用方法
发明专利
ZL 201710816183.8
注射器流量稳定装置
发明专利
ZL 201710461769.7
一种微流控移液器枪头
发明专利
ZL 201710238945.0
一种基于光诱导介电泳技术和纳米孔的DNA测序装置和测序方法
发明专利
ZL 201710235635.3
一种高通量微米粒子循环分选与浓缩装置及其制作方法
发明专利
ZL 201710227189.1
一种肿瘤细胞高通量分选富集微流控芯片
发明专利
ZL 201710153375.5
一种能实现细胞中心位置聚焦和检测的微流控芯片
发明专利
ZL 201710126436.9
一种制作银纳米线柔性透明导电薄膜的方法
发明专利
ZL 201610346327.3
一种微流控气体阻尼器及调节方法
发明专利
ZL 201510041153.5
一种微型被动流量调节阀及其制作工艺
发明专利
ZL 201610057507.X
3D实体电极介电泳纳米线操控系统
发明专利
ZL 201510380399.5
一种低成本微米粒子浓缩装置及其制作方法
发明专利
ZL 201510766988.7
一种夹片式微流控器件及制造方法
发明专利
ZL 201610299263.6
一种血管支架耦合系统血流动力学性能测试装置
发明专利
ZL 201010600719.0
一种多模式微混合器芯片及高通量混合和柔性混合方法
发明专利
ZL 201110407831.7
一种微米级粒子高通量分选的微流控器件及其制作方法
发明专利
ZL 201210175163.4
一种基于无掩模光刻的变高度微流道制作方法
发明专利
ZL 201510280209.2
一种集成细胞聚焦与检测的方法及其微型化系统
发明专利
ZL 201410154420.5
一种集成细胞分选及检测的微流控芯片系统
发明专利
ZL 201410348579.0
一种分离式微米级粒子自动组装、分选器件及其制作方法
发明专利
ZL 201310410606.8
一种稀有细胞多级分选微流控器件
发明专利
ZL 201310372705.1
单细胞多参数表征的微流控芯片检测系统
发明专利
ZL 201310066617.9
生物微粒高通量分选和计数检测的集成芯片系统及应用
发明专利
ZL 201110401804.9
一种具有高深宽比微流道的微流控芯片及其制作方法
ZL 201010591577.6
选通开关阵列及其应用方法
发明专利
近期论文
查看导师新发文章
(温馨提示:请注意重名现象,建议点开原文通过作者单位确认)
(1) Nan Xiang, Zhonghua Ni. Inertial Microfluidics for Single-Cell Manipulation and Analysis. In: Santra T., Tseng FG. (eds) Handbook of Single Cell Technologies. Springer, Singapore (参编图书章节)
(2) Nan Xiang*, Qiao Li, Zhonghua Ni*. Combining Inertial Microfluidics with Cross-Flow Filtration for High-Fold and High-Throughput Passive Volume Reduction. Analytical Chemistry, 2020, 92(9):6770-6776 (SCI,IF=6.785)
(3) Shu Zhu, Dan Wu, Yu Han, Cailian Wang, Nan Xiang*, Zhonghua Ni*. Inertial microfluidic cube for automatic and fast extraction of white blood cells from whole blood. Lab on a Chip, 2020, 20(2):244-252 (SCI,IF=6.774,正封面论文)
(4) Linbo Liu, Haoyan Xu, Haibo Xiu, Nan Xiang*, Zhonghua Ni*. Microfluidic on-demand engineering of longitudinal dynamic self-assembly of particles. Analyst, 2020, DOI: 10.1039/D0AN00653J (SCI,IF=3.978)
(5) Nan Xiang*, Qiao Li, Zhiguo Shi, Chenguang Zhou, Fengtao Jiang, Yu Han, Zhonghua Ni*. Low-cost multi-core inertial microfluidic centrifuge for high-throughput cell concentration. Electrophoresis, 2020, 41(10-11): 875-882 (SCI,IF=3.081)
(6) Linbo Liu, Nan Xiang*, Zhonghua Ni*. Droplet-based microreactor for the production of micro/nano-materials. Electrophoresis, 2020, 41(10-11): 833-851 (SCI,IF=3.081)
(7) Nan Xiang*, Rui Zhang, Yu Han, Zhonghua Ni*. A Multilayer Polymer-Film Inertial Microfluidic Device for High-Throughput Cell Concentration. Analytical Chemistry, 2019, 91(8):5461-5468 (SCI,IF=6.785)
(8) NanXiang*, Yu Han, Yuan Jia, Zhiguo Shi, Hong Yi, Zhonghua Ni*.Flow stabilizer on a syringe tip for hand-powered microfluidic sample injection. Lab on a Chip, 2019, 19(2): 214-222 (SCI,IF=6.774,正封面论文)
(9) Nan Xiang*, Wangjie, Qiao Li, Yu Han, Di Huang*, Zhonghua Ni*. Precise Size-Based Cell Separation via the Coupling of Inertial Microfluidics and Deterministic Lateral Displacement. Analytical Chemistry, 2019, 91(15):10328-10334 (SCI,IF=6.785)
(10) Xinjie Zhang, Kang Xia, Aimin Ji, Nan Xiang*. A smart and portable micropump for stable liquid delivery. Electrophoresis, 2019, 40(6): 865-872 (SCI,IF=3.081)
(11)Jingwen Mo*, Yaohuan Ding, Shu Zhu, Pan Kuang, Long Shen, Nan Xiang*, Jingjie Sha, Yunfei Chen*. Passive microscopic fluidic diodes using asymmetric channels. AIP Advances, 2019, 9(8):085117 (SCI,IF=1.337)
(12) Linbo Liu, Ke Chen, Nan Xiang*, Zhonghua Ni*. Dielectrophoretic manipulation of nanomaterials: a review. Electrophoresis, 2019, 40(6): 873-889 (SCI,IF=3.081)
(13) NanXiang *, Qing Dai, Yu Han, Zhonghua Ni*. Circular-channel particle focuser utilizing viscoelastic focusing. Microfluidics and Nanofluidics, 2019, 23(2):16 (SCI,IF=2.489)
(14) Wenlai Tang*, Di Jiang, Zongan Li, Liya Zhu, Jianping Shi, Jiquan Yang, Nan Xiang*. Recent advances in microfluidic cell sorting techniques based on both physical and biochemical principles. Electrophoresis, 2019, 40(6): 930-945 (SCI,IF=3.081)
(15) Wenlai Tang, Ning Fan, Jiquan Yang, Zongan Li, Liya Zhu, Di Jiang, Jianping Shi*, Nan Xiang*. Elasto-inertial particle focusing in 3D-printed microchannels with unconventional cross sections. Microfluidics and Nanofluidics, 2019, 23(3):42 (SCI,IF=2.489)
(16) Di Jiang, Di Huang, Gutian Zhao, Wenlai Tang*, NanXiang *. Numerical simulation of particle migration in different contraction–expansion ratio microchannels. Microfluidics and Nanofluidics, 2019, 23(1), 7 (SCI,IF=2.489)
(17) Nan Xiang*, Xin Shi, Yu Han, Zhiguo Shi, Fengtao Jiang, Zhonghua Ni*. Inertial Microfluidic Syringe Cell Concentrator. Analytical Chemistry, 2018, 90(15): 9515–9522 (SCI,IF=6.785)
(18) Nan Xiang*, Zhonghua Ni, Hong Yi*. Concentration‐controlled particle focusing in spiral elasto‐inertial microfluidic devices. Electrophoresis, 2018, 39(2): 417-424 (SCI,IF=3.081,封面论文)
(19) Xinjie Zhang, Zhixian Zhu, Nan Xiang*, Feifei Long, Zhonghua Ni*. Automated microfluidic instrument for label-free and high-throughput cell separation. Analytical Chemistry, 2018, 90(6): 4212–4220 (SCI,IF=6.785)
(20) Xin Wang, Ke Chen, Linbo Liu, Nan Xiang*, Zhonghua Ni*. Dielectrophoresis-based multi-step nanowire assembly on a flexible superstrate. Nanotechnology, 2018, 29(2):025301 (SCI,IF=3.551)
(21) Wenlai Tang, Dezhi Tang, Zhonghua Ni, Nan Xiang*, Hong Yi*. Microfluidic impedance cytometer with inertial focusing and liquid electrodes for high-throughput cell counting and discrimination. Analytical Chemistry, 2017, 89(5):3154-3161 (SCI,IF=6.785,当期研究亮点)
(22) Linbo Liu, Ke Chen*, Di Huang, Xin Wang, Nan Xiang*, Zhonghua Ni. A novel ‘leadless’ dielectrophoresis chip with dot matrix electrodes for patterning nanowires. Nanotechnology, 2017, 28(28):285302 (SCI,IF=3.551,正封面论文,英国皇家物理学会旗下nanotechweb.org网站专题报道)
(23) XinjieZhang, Zhixian Zhu, Zhonghua Ni, Nan Xiang*, Hong Yi*. Inexpensive, rapid fabrication of polymer-film microfluidic autoregulatory valve for disposable microfluidics. Biomedical Microdevices, 2017, 19(2):21 (SCI,IF=2.176)
(24) Wenlai Tang, Dezhi Tang, Zhonghua Ni, Nan Xiang*, Hong Yi*. A portable single-cell analysis system integrating hydrodynamic trapping with broadband impedance spectroscopy. Science China Technological Sciences, 2017, 60(11):1707-1715 (SCI,IF=2.302)
(25) Nan Xiang*, Qing Dai, Zhonghua Ni*. Multi-train elasto-inertial particle focusing in straight microfluidic channels. Applied Physcis Letters, 2016, 109(13):134101 (SCI,IF=3.597)
(26) Xinjie Zhang, Zhixian Zhu, Nan Xiang*, Zhonghua Ni*. A microfluidic gas damper for stabilizing gas pressure in portable microfluidic systems. Biomicrofluidics, 2016, 10(5):054123 (SCI,IF=2.5)
(27) Nan Xiang*, Xinjie Zhang, Qing Dai, Jie Cheng, Ke Chen, Zhonghua Ni*. Fundamentals of elasto-inertial particle focusing in curved microfluidic channels. Lab on a Chip, 2016, 16(14):2626-2635 (SCI,IF=6.774,背封面论文)
(28) Nan Xiang*, Di Huang, Jie Cheng, Ke Chen, Xinjie Zhang, Wenlai Tang, Zhonghua Ni*. Focusing dynamics of finite-sized particles in confined microfluidic channels. Applied Physics Express, 2016, 9(2):027001 (SCI,IF=3.086)
(29) Di Huang, Xin Shi, Yi Qian, Wenlai Tang, Linbo Liu, Nan Xiang*, Ni Zhonghua*. Rapid separation of human breast cancer cells from blood using a simple spiral channel device. Analytical Methods, 2016, 8(30): 5940-5948 (SCI,IF=2.596)
(30) Di Jiang, Wenlai Tang, Nan Xiang*, Zhonghua Ni*. Numerical simulation of particle focusing in a symmetrical serpentine microchannel. RSC Advances,2016, 6(62): 57647-57657 (SCI,IF=3.119)
(31) Xinjie Zhang, Xin Wang, Ke Chen, Jie Cheng, Nan Xiang*, Zhonghua Ni*.Passive flow regulator for precise high-throughput flow rate control in microfluidic environments. RSC Advances, 2016, 6(38): 31639-31646 (SCI,IF=3.119)
(32) Xinjie Zhang, Di Huang, Wenlai Tang, Di Jiang, Ke Chen, Hong Yi, Nan Xiang*, Zhonghua Ni*. A low cost and quasi-commercial polymer film chip for high-throughput inertial cell isolation. RSC Advances, 2016, 6(12): 9734-9742 (SCI,IF=3.119)
(33) Nan Xiang*, Zhonghua Ni. High-throughput blood cell focusing and plasma isolation using spiral inertial microfluidic devices. Biomedical Microdevices, 2015, 17(6): 110-121 (SCI,IF=2.176)
(34) Nan Xiang, Zhiguo Shi, Wenlai Tang, Di Huang, Xinjie Zhang, Zhonghua Ni*. Improved understanding of particle migration modes in spiral inertial microfluidic devices. RSC Advances, 2015, 5(94): 77264-77273 (SCI,IF=3.119)
(35)Xinjie Zhang, Nan Xiang (共同一作), Wenlai Tang, Di Huang, Xin Wang, Hong Yi, Zhonghua Ni*. A passive flow regulator with low threshold pressure for high-throughput inertial isolation of microbeads. Lab on a Chip, 2015, 15(17): 3473-3480 (SCI,IF=6.774,正封面论文)
(36) Nan Xiang, Ke Chen, Qing Dai, Di Jiang, Dongke Sun, Zhonghua Ni*. Inertia-induced focusing dynamics of microparticles throughout a curved microfluidic channel. Microfluidics and Nanofluidics, 2015, 18(1): 29-39 (SCI,IF=2.489)
(37) Nan Xiang, Hong Yi, Ke Chen, Dongke Sun, Di Jiang, Qing Dai, Zhonghua Ni*. High-throughput inertial particle focusing in a curved microchannel: Insights into the flow-rate regulation mechanism and process model. Biomicrofluidics, 2013, 7(4): 044116 (SCI,IF=2.5)
(38) Nan Xiang, Hong Yi, Ke Chen, Shanfang Wang, Zhonghua Ni*. Investigation of the maskless lithography technique for the rapid and cost-effective prototyping of microfluidic devices in laboratories. Journal of Micromechanics and Microengineering, 2013, 23(2): 025016 (SCI,IF=1.739)
(39) Nan Xiang, Ke Chen, Dongke Sun, Shanfang Wang, Hong Yi, Zhonghua Ni*. Quantitative characterization of the focusing process and dynamic behavior of differently sized microparticles in a spiral microchannel. Microfluidics and Nanofluidics, 2013, 14(1-2): 89-99 (SCI,IF=2.489)
(40) Nan Xiang, Xiaolu Zhu, Zhonghua Ni*. Application of Inertial Effect in Microfluidic Chips. Progress in Chemistry, 2011, 23(9): 1945-1958 (SCI,IF=1.013)