个人简介

Michael is interested in using human stem cells to better understand normal human development and disease progression. His current research activity makes use of human pluripotent stem cells (i.e. cells that can produce any cell type of the body) to learn more about cataract, a variety of conditions that involve degradation of the ocular lens leading to blindness. Michael obtained his PhD from the University of Sydney in 2005, creating an animal-based culture system that can regenerate functional ocular lenses in the laboratory. Upon completing his PhD Michael undertook postdoctoral studies in Vancouver (Canada), where he identified new genes and mechanisms that help maintain the developmental potential of human pluripotent stem cells. Michael has received numerous awards for his work in both the lens and human pluripotent stem cell fields, and together these diverse areas of expertise provide a unique opportunity to understand lens and cataract development using human cells. Throughout his career, Michael has also maintained an interest in translating academic research findings into biotechnology or clinical applications, through interactions with both Australian and Canadian biotechnology companies.

研究领域

Regenerative Medicine

Cataract Lens Development Pluripotent Stem Cells Regenerative Medicine

近期论文

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Taylor, D., Thevarajah, J., Narayan, D., Murphy, P., Mangala, M., Lim, S., Wuhrer, R., Lefay, C., O'Connor, M., Gaborieau, M. and Castignolles, P. (2015), 'Real-time monitoring of peptide grafting onto chitosan films using capillary electrophoresis', Analytical and Bioanalytical Chemistry, vol 407, no 9 , pp 2543 - 2555. Meng, W., Zhou, J., Elliott, R., Murphy, P., Ho, V. and O'Connor, M. (2015), 'Is there a role for human pluripotent stem cells in modelling interstitial cells of cajal and gut motility disorders?', Current Stem Cell Research & Therapy, vol 10, no 3 , pp 251 - 257. Main, H., Munsie, M. and O'Connor, M. (2014), 'Managing the potential and pitfalls during clinical translation of emerging stem cell therapies', Clinical and Translational Medicine, vol 3, no 10 . Ooi, L., Sidhu, K., Poljak, A., Sutherland, G., O'Connor, M., Sachdev, P. and Muench, G. (2013), 'Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer's disease', Journal of Neural Transmission, vol 120, no 1 , pp 103 - 111. O'Connor, M. (2013), 'The 3R principle : advancing clinical application of human pluripotent stem cells', Stem Cell Research and Therapy, vol 4, no 2 . Caron, N., Gage, B., O'Connor, M., Eaves, C., Kieffer, T. and Piret, J. (2013), 'A human embryonic stem cell line adapted for high throughput screening', Biotechnology and Bioengineering, vol 110, no 10 , pp 2706 - 2716. O'Connor, M., Wederell, E., Robertson, G., Delaney, A., Morozova, O., Poon, S., Yap, D., Fee, J., Zhao, Y., McDonald, H., Zeng, T., Hirst, M., Marra, M., Aparicio, S. and Eaves, C. (2011), 'Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance', Experimental Hematology, vol 39, no 8 , pp 866 - 8790. Lu, M., Kardel, M., O'Connor, M. and Eaves, C. (2009), 'Enhanced generation of hematopoietic cells from human hepatocarcinoma-cell stimulated human embryonic stem cells', Experimental Hematology, vol 37, no 8 , pp 924 - 936. O'Connor, M., Kardel, M., Iosfina, M., Youssef, D., Lu, M., Li, M., Vercauteren, S., Nagy, A. and Eaves, C. (2008), 'Alkaline phosphatase-positive colony formation is a sensitive, specific and quantitative indicator of undifferentiated human embryonic stem cells', Stem Cells, vol 26 , pp 1109 - 1116. Morin, R., O'Connor, M., Griffith, M., Kuchenbauer, F., Delaney, A., Prabhu, A., Zhao, Y., McDonald, H., Zeng, T., Hirst, M., Eaves, C. and Marra, M. (2008), 'Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells', Genome Research, vol 18, no 4 , pp 610 - 621. Banuelos, C., Banath, J., MacPhail, S., Zhao, J., O'Connor, M., Eaves, C., Lansdorp, P. and Olive, P. (2008), 'Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks', DNA Repair, vol 7, no 9 , pp 1471 - 1483. O'Connor, M., Wederell, E., De Longh, R., Lovicu, F. and McAvoy, J. (2008), 'Generation of transparency and cellular organization in lens explants', Experimental Eye Research, vol 86, no 5 , pp 734 - 745. Hirst, M., Delanley, A., Rogers, S., Schnerch, A., Persaud, D., O'Connor, M., Zeng, T., Moksa, M., Fichter, K., Mah, D., Go, A., Morin, R., Baross, A., Zhao, A., Khattra, J., Prabhu, A., Pandoh, P., McDonald, H., Asano, J., Dhalla, N., Ma, K., Lee, S., Ally, A., Chahal, N., Menzies, S., Siddiqui, A., Holt, R., Jones, S., Gerhard, D., Thomson, J., Eaves, C. and Marra, M. (2007), 'LongSAGE profiling of nine human embryonic stem cell lines', Genome Biology, vol 8, no 6 , pp 113 - 113. Ungrin, M., O'Connor, M., Eaves, C. and Zandstra, P. (2007), 'Phenotypic analysis of human embryonic stem cells', Current Protocols in Stem Cells, . O'Connor, M. and McAvoy, J. (2007), 'In vitro generation of functional lens-like structures with relevance to age-related nuclear cataract', Investigative Ophthalmology and Visual Science, vol 48, no 3 , pp 1245 - 1252. Wederell, E., Brown, H., O'Connor, M., Chamberlain, C., McAvoy, J. and De Longh, R. (2005), 'Laminin-binding integrins in rat lens morphogenesis and their regulation during fibre differentiation.', Experimental Eye Research, vol 81, no 3 , pp 326 - 329.