个人简介

Dr Gyengesi was awarded her PhD in 2010 from the Eotvos Lorand University, Budapest, Hungary, conducting research in the lab of Prof Laszlo Detari. During her PhD she developed and assembled an in vivo electrophysiology set-up for juxtacellular labelling of individual neurons in anaesthetized animals and used this technique to label and immunohistochemically identify neurons in the basal forebrain that are correlated with the EEG activity in the neocortex. During her graduate studies, she collaborated with Dr. Laszlo Zaborszky at the Centre of Molecular and Behavioural Neuroscience, Rutgers University, Newark, NJ, spending a year and a half as a research assistant in his lab. During that time she investigated the anatomical connections between the basal forebrain and the medial prefrontal cortex. In 2007, she became a postdoctoral research associate in the laboratory of Dr. Sabrina Diano at Yale University, New Haven, Connecticut, USA, at the Department of Obstetrics, Gynaecology & Reproductive Sciences. There, she studied the effect of metabolic changes on synaptic input organization of NPY/AgRP POMC/CART containing neurons in mice hypothalamus. The hypothalamus is closely connected with the basal forebrain and shares some general functions in regulation of sleep. She introduced new techniques (including mitochondria isolation from brain tissue, membrane potential measurements, reactive oxygen species production measurements) to Dr Diano’s lab after learning these new methods on a research trip to the laboratory of Dr Roger F. Castilho at the Universidade Estadual de Campinas, in Campinas, Brazil. Results of this work were published in two high impact factor journals. In 2010 she accepted the opportunity as a postdoctoral research officer in the laboratory of Dr. George Paxinos at Neuroscience Research Australia (NeuRA). She was involved in two major anatomical mapping projects, one of which is creating a stereotaxic atlas of the marmoset brain, and the other a collaboration with the Brain Research Institute (BRI), Melbourne to map the myelin system of the mouse brain in relation to high resolution MRI. At the end of 2012, she joined the lab of Prof Gerald Muench, at the University of Western Sydney, joining the School of Medicine first as a full time research officer for the Pharmacology group, later appointed as an associate lecturer. Her work at UWS focuses on the effects of chronic neuroinflammation in the rodent brain, in particular, on the basal forebrain cholinergic system. Dr Gyengesi has been focusing on neuroscience, investigating different networks and their anatomical and functional properties of the rodent brain. The two main areas that she got most involved and interested in include the basal forebrain and the corticopetal cholinergic system and the hypothalamic areas and its role in regulating food intake and weight. These two systems are involved in diseases that are getting more and more attention due to their increasing numbers in our societies. Alzheimer’s disease is one of the most devastating neurodegenerative diseases and the number of people affected will multiply in the next few decades. Type II diabetes is unfortunately also on the rise even among children especially in the United States but also in Australia.

研究领域

Pharmacology

Basal forebrain cholinergic system Neuroscience

近期论文

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Gunawardena, D., Karunaweera, N., Lee, S., van der Kooy, F., Harman, D., Raju, R., Bennett, L., Gyengesi, E., Sucher, N. and Muench, G. (2015), 'Anti-inflammatory activity of cinnamon (C. zeylanicum and C. cassia) extracts - identification of e-cinnamaldehyde and o-methoxy cinnamaldehyde as the most potent bioactive compounds', Food & Function, vol 6, no 3 , pp 910 - 919. Karunaweera, N., Raju, R., Gyengesi, E. and Muench, G. (2015), 'Plant polyphenols as inhibitors of NF-KB induced cytokine production : a potential anti-inflammatory treatment for Alzheimer's disease?', Frontiers in Molecular Neuroscience, vol 8 . Venigalla, M., Sonego, S., Gyengesi, E. and Muench, G. (2015), 'Curcumin and apigenin : novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease', Neural Regeneration Research, vol 10, no 8 , pp 1181 - 1185. Gunawardena, D., Bennett, L., Shanmugam, K., King, K., Williams, R., Zabaras, D., Head, R., Ooi, L., Gyengesi, E. and Muench, G. (2014), 'Anti-inflammatory effects of five commercially available mushroom species determined in lipopolysaccharide and interferon-gamma activated murine macrophages', Food Chemistry, vol 148 , pp 92 - 96. Williams, R., Muench, G., Gyengesi, E. and Bennett, L. (2014), 'Bacopa monnieri (L.) exerts anti-inflammatory effects on cells of the innate immune system in vitro', Food and Function, vol 5, no 3 , pp 517 - 520. Millington, C., Sonego, S., Karunaweera, N., Rangel, A., Aldrich-Wright, J., Campbell, I., Gyengesi, E. and Muench, G. (2014), 'Chronic neuroinflammation in Alzheimer's disease : new perspectives on animal models and promising candidate drugs', BioMed Research International, vol 2014 . Apetz, N., Muench, G., Govindaraghavan, S. and Gyengesi, E. (2014), 'Natural compounds and plant extracts as therapeutics against chronic inflammation in Alzheimer's disease - a translational perspective', CNS & Neurological Disorders Drug Targets, vol 13, no 7 , pp 1175 - 1191. Gyengesi, E., Andrews, Z., Paxinos, G. and Zaborszky, L. (2013), 'Distribution of secretagogin-containing neurons in the basal forebrain of mice, with special reference to the cholinergic corticopetal system', Brain Research Bulletin, vol 94 , pp 1 - 8. Gyengesi, E., Calabrese, E., Sherrier, M., Johnson, G., Paxinos, G. and Watson, C. (2013), 'Semi-automated 3D segmentation of major tracts in the rat brain : comparing DTI with standard histological methods', Brain Structure and Function, .